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Vol 15 (2023): (Suppl. 1) Neuromyelitis optic spectrum disorders (NMOSD): from pathogenesis to targeted therapy Abstract  similar documents
P. A. Zaitseva, A. N. Boyko
"... of patients with NMOSD and antibodies to APQ4-IgG: e eculizumab and satralizumab. The remaining drugs ..."
 
Vol 17, No 4 (2025) Divozilimab reduces the risk of exacerbations in patients with neuromyelitis optica spectrum disorders Abstract  similar documents
A. N. Boyko, M. N. Zakharova, T. O. Simaniv, V. M. Alifirova, E. G. Arefieva, M. A. Barabanova, Z. A. Goncharova, I. V. Greshnova, N. V. Dorogov, V. A. Dudin, D. S. Korobko, S. V. Kotov, G. N. Mishin, E. V. Parshin, I. E. Poverennova, D. V. Pokhabov, V. M. Lebedev, I. V. Smagina, N. N. Spirin, S. A. Sivertseva, N. A. Totolyan, D. F. Khairutdinova, T. N. Trushnikova, L. G. Zaslavsky, K. Z. Bakhtiyarova, E. V. Prazdnichkova, F. A. Khabirov, A. G. Bunyak, R. E. Yakubtsevich, D. G. Tolkacheva, K. V. Sapozhnikov, O. N. Mironenko, A. A. Lazarev, V. D. Batorova, M. V. Krasnova, A. A. Porozova, A. V. Eremeeva, Yu. N. Linkova, A. V. Zinkina-Orikhan
"... disorder (NMOSD). Material and methods. The AQUARELLE clinical trial population included patients aged 18 ..."
 
Vol 13, No 5 (2021) Consensus of expert advices on routing, diagnosis, and management of patients with neuromyelitis optica spectrum disorders Abstract  PDF (Eng)  similar documents
A. N. Boyko, K. Z. Bakhtiyarova, L. V. Brylev, M. N. Zakharova, D. S. Kasatkin, D. S. Korobko, S. V. Kotov, V. S. Krasnov, N. A. Malkova, E. V. Popova, S. A. Sivertseva, T. O. Simaniv, A. A. Sokolova, N. A. Totolyan, T. N. Trushnikova, F. A. Khabirov, N. V. Khachanova
"... related to various aspects of medical care for patients with NMOSDs. As a result, the experts developed ..."
 
Vol 15, No 1 (2023) Comments on the article “Consensus opinion on the management of patients with neuromyelitis optica spectrum diseases: issues of terminology and therapy” Abstract  similar documents
A. N. Boyko
"... for 2022. The main comments relate to the management of patients with NMOSD who do not have antibodies ..."
 
Vol 14, No 6 (2022) Consensus opinion on the management of patients with neuromyelitis optica spectrum diseases: issues of terminology and therapy Abstract  similar documents
V. S. Krasnov, K. Z. Bakhtiyarova, E. P. Evdoshenko, D. S. Korobko, T. O. Simaniv, N. A. Totolyan, N. V. Khachanova, M. V. Shumilina, M. V. Davydovskaya
"... , there are several unresolved issues that make it difficult to provide medical care to patients with NMOSD ..."
 
Vol 16, No 6 (2024) Neuromyelitis optica spectrum disorders, terminology and therapeutic issues: amended consensus opinion Abstract  similar documents
V. S. Krasnov, Yu. V. Vlasov, E. P. Evdoshenko, D. S. Korobko, M. D. Matson, A. I. Nilov, A. A. Sokolova, N. A. Totolian, N. V Khachanova, M. V. Shumilina, M. V. Davydovskaya
"... for neuromyelitis optica spectrum disorders (NMOSD) and proposed a treatment algorithm for patients with NMOSD ..."
 
Vol 16 (2024): (Suppl. 2) Neuromyelitis optica spectrum disorders in children Abstract  similar documents
N. F. Akhmetgaleeva, T. O. Simaniv, E. M. Yausheva, Yа. A. Saitova, O. V. Lyutov, M. A. Kutlubaev, K. Z. Bakhtiyarova
"... In recent decades, the prevalence of demyelinating diseases in paediatric patients has increased ..."
 
Vol 15 (2023): (Suppl. 1) Delayed diagnosis of the neuromyelitis optica spectrum disorder Abstract  similar documents
S. A. Dzhukkaeva, E. V. Ermilova, Sh. R. Nabiev, O. N. Voskresenskaya
"... criteria for NMOSD. The majority of patients with NMOSD have aquaporin-4 autoantibody (AQP4-IgG). This case ..."
 
Vol 17, No 4 (2025) Clinical and social study and assessment of quality of life in patients with neuromyelitis optica spectrum disorders Abstract  similar documents
Yu. V. Vlasov, V. M. Alifirova, N. N. Babicheva, K. Z. Bakhtiyarova, O. V. Bragina, Z. A. Goncharova, N. Yu. Gorokhova, I. V. Greshnova, O. V. Dzundza, E. A. Dubchenko, Zh. I. Kapustenskaya, M. I. Karpova, D. S. Korobko, E. V. Krivomlina, E. V. Nikishova, E. S. Novikova, S. A. Sivertseva, T. N. Trushnikova, E. L. Turova, G. E. Sheiko, M. A. Sherman, A. Ya. Hajduk, N. G. Polyarnaya, A. N. Boyko
"... diagnosed with NMOSD (opticoneuromyelitis). Material and methods. The condition of patients ..."
 
Vol 15 (2023): (Suppl. 1) Diagnostic criteria and treatment of neuromyelitis optica spectrum disorders (NMOSD) Abstract  similar documents
T. O. Simaniv, K. Z. Bakhtiyarova, A. N. Belova, Z. A. Goncharova, S. A. Sivertseva, N. N. Spirin, N. A. Totolyan, T. N. Trushnikova, E. L. Turova, T. I. Khaibullin, M. A. Sherman, A. N. Boyko
"... Neuromyelitis optic spectrum disorders (NMOSD) are rare, severely disabling diseases ..."
 
Vol 13, No 4 (2021) Anti-B-cell therapy in patients with neuromyelitis optica spectrum disorders Abstract  PDF (Eng)  similar documents
S. V. Kotov, E. S. Novikova, A. S. Kotov
"... to aquaporin-4 (AQP4-IgG). However, AQP4-IgG is not detected in at least 10-20% of patients with NMOSDs ..."
 
Vol 17, No 4 (2025) The challenges of diagnosing neuromyelitis optica spectrum disorders without antibodies to aquaporin-4 Abstract  similar documents
T. O. Simaniv, M. N. Zakharova
"... patients who were referred to the Russian Сenter of Neurology and Neurosciences with a diagnosis of NMOSD ..."
 
Vol 16, No 3 (2024) Cognitive impairment in neuromyelitis optica spectrum disorders Abstract  similar documents
E. A. Vekhina, D. S. Kasatkin, S. E. Korchevnyi, K. I. Bereznyak
"... studies, the prevalence of cognitive impairment (CI) in 761 patients with NMOSD aged 34 to 53 years ..."
 
Vol 16 (2024): (Suppl. 2) Pain in patients with neuromyelitis optica spectrum disorders Abstract  similar documents
E. S. Novikova, A. S. Kotov, S. V. Kotov
"... in the population of NMOSD patients in Moscow region, to investigate its clinical characteristics and its impact ..."
 
Vol 10, No 1 (2018) Neuromyelitis optica spectrum disorders in pediatric patients Abstract  similar documents
Yu. V. Tokareva, A. S. Kotov, M. V. Panteleeva, M. S. Bunak
"... in pediatric patients followed up by the authors. It presents the criteria for diagnosing NMOSDs ..."
 
Vol 17, No 4 (2025) The role of central vein sign in differential diagnostics of neuromyelitis optica spectrum disorders and multiple sclerosis Abstract  similar documents
S. V. Kotov, E. S. Novikova, G. T. Tonya, A. S. Kotov
"... in patients with MS, while in patients with NMOSD the number of cerebral lesions was minimal, and only one ..."
 
Vol 16 (2024): (Suppl. 2) High-dose immunosuppressive therapy followed by haematopoietic stem cell transplantation as a method for the treatment of refractory forms of neuromyelitis optica spectrum disorder in children Abstract  similar documents
N. N. Bronina, O. V. Bykova, G. O. Bronin, A. E. Kessel, G. Z. Seregin, K. I. Kirgizov, A. Yu. Polushin, T. T. Batysheva
"... of NMOSD. The choice of HSCT type may depend on the severity of the patient’s somatic and neurological ..."
 
Vol 14, No 5 (2022) Current view on the diagnosis and treatment of neuromyelitis optica spectrum disorders exacerbations Abstract  similar documents
V. S. Krasnov, L. N. Prakhova, N. A. Totolyan
"... of exacerbations is a key task in the management of this category of patients. A unified structured approach ..."
 
Vol 16, No 3 (2024) Optic neuritis in various demyelinating diseases Abstract  PDF (Eng)  similar documents
A. K. Kalashnikova, D. D. Eliseeva, N. A. Andreeva, N. V. Zhorzholadze, I. A. Ronzina, R. Ts. Bembeeva, N. N. Venediktova, M. R. Kalganova, N. L. Sheremet
"... . ON was observed in the onset of the disease in 75% of NMOSD patients, 62% of MOGAD patients and 86% of MS/iDON ..."
 
Vol 15, No 6 (2023) Neuromyelitis optica spectrum disorders and complement system: issues of pathogenesis and therapeutic options Abstract  similar documents
V. S. Krasnov
"... An important component of the pathogenesis of neuromyelitis optica spectrum diseases (NMOSD ..."
 
Vol 12, No 3 (2020) Anti-MOG associated myelitis Abstract  PDF (Eng)  similar documents
A. I. Isaykin, O. N. Voskresenskaya, T. I. Kuzminova, E. V. Ermilova, O. V. Stezhko
"... for neuromyelitis optica spectrum diseases (NMOSD), as well as red flags, in the absence of which the diagnosis ..."
 
Vol 15 (2023): (Suppl. 1) Clinical course features of atypical demyelinating optic neuritis: case series Abstract  similar documents
N. L. Sheremet, D. D. Eliseeva, V. V. Bryukhov, N. A. Andreeva, N. V. Zhorzholadze, Yu. K. Murakhovskaya, A. K. Kalashnikova, M. N. Zakharova
"... of neuromyelitis optica spectrum disorders (NMOSD) and diseases associated with myelin oligodendrocyte glycoprotein ..."
 
Vol 6, No 2 (2014) Impact of patient information-educational preparation on clinical, financial, and economic factors and treatment satisfaction Abstract  similar documents
A.B. Danilov, E.V. Shevchenko
"... , and improve patient satisfaction with treatment. The implementation of the educational programs ..."
 
Vol 10, No 1S (2018): СПЕЦВЫПУСК: ЭПИЛЕПСИЯ Sociocultural aspects and different types of stigmatization in epilepsy Abstract  similar documents
E. V. Parfenova, F. K. Rider, A. G. Gersamia
"... of patients, relatives, and society as a whole towards epilepsy. It discusses the stigma that is associated ..."
 
Vol 13, No 1 (2021) Causes of ischemic stroke in patients younger than 45 years: analysis of data from the regional vascular center Abstract  PDF (Eng)  similar documents
A. A. Kulesh, Yu. A. Nurieva, L. I. Syromyatnikova
"... In young patients, the causes of ischemic stroke (IS) are substantially different from those ..."
 
Vol 11, No 3 (2019) Rehabilitation in acute stroke from the point of view of evidence-based medicine: possibilities of drug treatment Abstract  similar documents
A. A. Kulesh
"... , the benefits and risks of early and very early patient mobilization. It presents data on the efficiency of CIMT ..."
 
Vol 8, No 2 (2016) Effectiveness of prolonged-release melatonin in Improving Quality of Sleep in Patients Aged 55 or Over Abstract  similar documents
G. V. Kovrov, M. V. Agaltsov, Z. N. Sukmarova
"... to improve sleep quality in Russian patients over 55 years of age. Patients and methods. The results ..."
 
Vol 14, No 5 (2022) Safety of Mexidol® (ethylmethylhydroxypyridine succinate) in adult patients of different age groups Abstract  similar documents
E. A. Ushkalova, S. K. Zyryanov, O. I. Butranova
"... patients to treatment, it is recommended to limit maximally the total number of prescribed drugs (DR ..."
 
Vol 14, No 1 (2022) Treatment of spasticity in patients with the consequences of traumatic brain injury Abstract  similar documents
A. P. Kovalenko, I. A. Vozniuk, K. M. Naumov, V. Yu. Lobzin, S. Yu. Kirtaev
"... Up to 16–20% of patients with a history of traumatic brain injury (TBI), regardless of its ..."
 
Vol 8, No 1 (2016) Factors determining social (interpersonal) support in patients with vertebro-spinal cord injury Abstract  similar documents
I. D. Boulyubash, O. S. Bashta
"... Objective: to study relationships between the specific features of the social network of patients ..."
 
Vol 9, No 2 (2017) The psychological trajectory in a patient with vertebral and spinal cord injury sequels Abstract  similar documents
I. D. Boulyubash
"... in patients with VSCI assumes that a psychotherapist diagnosing and correcting this condition should ..."
 
Vol 7, No 1S (2015): Special issue "Epilepsy" Efficacy of generic levetiracetam (epiterra) in monotherapy for epilepsy in adult patients: preliminary results Abstract  similar documents
V. A. Karlov, P. N. Vlasov, I. A. Zhidkova
"... ) in adult patients with focal epilepsy (FE) or juvenile myoclonic epilepsy (JME) who took the drug for і6 ..."
 
Vol 6, No 1 (2014) Severe dementia: diagnosis, patient management, prevention of complications Abstract  similar documents
A.B. Lokshina
"... dementia patients. The differences in the severity levels of dementia are discussed in detail; special ..."
 
Vol 6, No 4 (2014) Patient management in the recovery period of stroke Abstract  similar documents
O. V. Kosivtsova
"... disorders, and pelvic organ dysfunctions. The patients’ quality of life largely depends on the degree ..."
 
Vol 17, No 4 (2025) Cytokine profile of blood serum in patients with demyelinating diseases affecting the spinal cord and associated pain syndrome Abstract  similar documents
E. V. Ermilova, O. N. Voskresenskaya, S. L. Ryzhikova, Yu. G. Druzhinina, N. V. Timofeeva, K. I. Yakovleva, A. A. Kolodyazhnaya, T. P. Ospelnikova
"... of demyelination in the spinal cord and 14 patients with NMOSD). The main group consisted of 13 patients ..."
 
Vol 15, No 2 (2023) Clinical course and diagnosis of cerebral vein and sinus thrombosis associated with COVID-19 in young and middle-aged patients Abstract  similar documents
E. G. Klocheva, V. V. Goldobin, F. Z. Olimova
"... , mortality in patients with CVT on the background of COVID-19 significantly exceeds the mortality in patients ..."
 
Vol 13, No 3 (2021) Role of educational programs in management of patients with medication-overuse headache Abstract  PDF (Eng)  similar documents
A. E. Shagbazyan, N. A. Kovalchuk, G. R. Tabeeva
"... Patients with primary headaches are prone to frequent uncontrolled use of analgesics, leading ..."
 
Vol 10, No 1S (2018): СПЕЦВЫПУСК: ЭПИЛЕПСИЯ An open-label prospective clinical study of the efficacy and tolerability of brand-name and generic levetiracetam in the monotherapy of focal epilepsy in adults Abstract  similar documents
V. A. Karlov, P. N. Vlasov, I. A. Zhidkova
"... , TEVA, Israel) in adolescent (over 16 years of age) and adult patients with focal epilepsy (FE) during ..."
 
Vol 9, No 1S (2017): SPECIAL ISSUE: EPILEPSY Stigmatization of patients with epilepsy Abstract  similar documents
E. V. Parfenova, F. K. Rider, A. G. Gersamia
"... of patients with epilepsy. The cognitive beliefs of society and patients, which are associated ..."
 
Vol 15, No 1 (2023) Management of patients with cognitive impairment Abstract  similar documents
V. A. Parfenov
"... The management of patients with cognitive impairment (CI) is one of the urgent problems of modern ..."
 
Vol 11, No 2 (2019) Insomnia in patients with migraine Abstract  similar documents
E. M. Evdokimova, G. R. Tabeeva
"... and for the elaboration of strategies for its prevention. Patients and methods. A prospective comparative study ..."
 
Vol 2, No 2 (2010) Possibilities of using Tanakan ® in therapy for generalized anxiety syndrome Abstract  similar documents
D. Yu. Veltishchev
"... . The successful use of the drug in moderate anxiety states in elderly patients having cognitive disorders ..."
 
Vol 13, No 1 (2021) Food refusal in mentally ill patients and their management tactics Abstract  similar documents
D. S. Danilov, M. E. Kotik (Matsneva), I. I. Yakovleva
"... in mentally ill patients. It systematizes information about methods for preventing and supplying nutrient ..."
 
Vol 13, No 4 (2021) Rehabilitation of patients after lumbar microdiscectomy Abstract  similar documents
V. S. Prokopovich, V. A. Parfenov
"... in the rehabilitation of patients after lumbar microdiscectomy. Patients and methods. We enrolled 90 patients (33 men ..."
 
Vol 5, No 2S (2013): Special issue "Stroke" Management of patients with post-stroke dementia Abstract  similar documents
Svetlana Viktorovna Verbitskaya
"... Dementia occurs in 10-20% of cases and substantially hampers the rehabilitation of patients who ..."
 
Vol 15, No 2 (2023) Depression in patients with cerebral microangiopathy Abstract  similar documents
A. N. Bogolepova
"... . Given the complexity of the mechanisms of development of depressive disorders in patients with CMA ..."
 
Vol 8, No 1 (2016) Management of patients with neck pain Abstract  similar documents
E. A. Chechet, V. A. Parfenov
"... regresses; however, it recurs in almost one half of patients. The paper gives data on the risk factors ..."
 
Vol 14, No 4 (2022) Cognitive impairment in patients with coronavirus infection Abstract  similar documents
Y. A. Starchina, O. V. Kosivtsova
"... between CI and SARS-CoV-2 infection appears to be two-way: patients with premorbid CI have a higher risk ..."
 
Vol 15, No 2 (2023) Management of patients with chronic cerebrovascular disease Abstract  similar documents
Yu. A. Starchina, O. V. Kosivtsova, E. A. Sokolov
"... the leading role in the treatment of patients with cerebrovascular diseases. It is necessary to pay special ..."
 
Vol 10, No 3 (2018) Treatment of patients with acute and subacute dorsalgia Abstract  similar documents
O. N. Gerasimova, V. A. Parfenov, E. Yu. Kalimeeva
"... , by providing information to patients and by using nonsteroidal anti-inflammatory drugs (NSAIDs) without ..."
 
Vol 12, No 3 (2020) Heterogeneity of myelopathy in patients with systemic sarcoidosis Abstract  similar documents
V. S. Krasnov, V. V. Zuykova, E. V. Bubnova, O. P. Baranova, A. A. Skoromets
"... Myelopathy occurs in 1% of patients with sarcoidosis and is usually caused by the underlying ..."
 
Vol 10, No 1 (2018) Vestibular vertigo treatment in a polymorbid patient Abstract  similar documents
O. V. Kosivtsova, S. A. Yavorskaya, T. G. Fateeva
"... Many physicians have difficulty managing patients with vertigo. Incorrect routine diagnoses ..."
 
Vol 10, No 2 (2018) Current management tactics for patients with dementia Abstract  similar documents
A. V. Medvedeva, O. V. Kosivtsova, K. A. Makhinov
"... in the patient for as long as possible and to slow down disability, thus ensuring higher living standards. CI ..."
 
Vol 7, No 1S (2015): Special issue "Epilepsy" Factors influencing the stigmatization of patients with epilepsy Abstract  similar documents
I. A. Grigoryeva, L. A. Troitskaya
"... Objective: to identify the factors influencing the stigmatization in patients with epilepsy ..."
 
Vol 2, No 3 (2010) Personality characteristics in patients with somatized disorder Abstract  similar documents
E. A. Tolkach
"... with their people in patients with somatized disorder. Subjects and methods. Eighty-six patients diagnosed ..."
 
Vol 14, No 1S (2022): Спецвыпуск: рассеянный склероз Rehabilitation of patients with progressive forms of multiple sclerosis Abstract  similar documents
S. A. Sivertseva, K. S. Anfilofyeva, A. V. Zotova, A. A. Belkin, M. A. Sherman
"... Rehabilitation has an important place in the treatment and management of patients with multiple ..."
 
Vol 11, No 2 (2019) Diabetic polyneuropathy: a current algorithm for patient management Abstract  similar documents
L. T. Akhmedzhanova, A. N. Barinov, O. A. Solokha, I. A. Strokov, O. B. Doronina, K. S. Doronina, A. S. Rozhdestvensky
"... , leads to worse quality of life and its shorter expectancy in patients. The paper discusses current ..."
 
Vol 4, No 2S (2012): Сognitive and other neuropsychiatric disorders Cognitive impairments in patients with prior ischemic stroke Abstract  similar documents
V. A. Parfenov, M. A. Cherdak, N. V. Vakhnina, S. V. Verbitskaya, L. Yu. Nikitina
"... ). The latter occurs in 35—83% of patients; poststroke does in 6—40%. Different mechanisms of PSCI are under ..."
 
Vol 15, No 3 (2023) Issues of management of patients with post-stroke cognitive impairment Abstract  similar documents
A. B. Lokshina, D. A. Grishina
"... ) significantly contribute to the disability of patients after a stroke, which limit daily activities no less than ..."
 
Vol 16, No 1S (2024): Спецвыпуск: Головная боль Typical clinical practice of treating patients with chronic migraine Abstract  similar documents
V. A. Golovacheva, A. A. Golovacheva, A. R. Tarshilova, V. V. Osipova
"... of treating patients with CM in our country has not been sufficiently investigated, which formed the basis ..."
 
Vol 14, No 3 (2022) The efficacy of ipidacrine in patients with diabetic polyneuropathy Abstract  similar documents
P. R. Kamchatnov, E. R. Barantsevich, A. V. Chugunov, A. A. Kabanov, B. A. Abusueva
"... Peripheral nervous system involvement in patients with type 2 diabetes mellitus is a severe ..."
 
Vol 11, No 1 (2019) Antidepressant therapy in patients with cardiovascular diseases Abstract  similar documents
V. E. Medvedev, E. A. Korovyakova, V. I. Frolova, E. V. Gushanskaya
"... Depression is the most common form of mental illness in patients with cardiovascular diseases (CVD ..."
 
Vol 8, No 4 (2016) NEUROLOGICAL DISORDERS IN PATIENTS WITH HYPERTENSION AND THEIR CORRECTION Abstract  similar documents
N. V. Vakhnina, O. V. Milovanova
"... Neurological disorders in hypertensive patients can be caused by both brain injury and concomitant ..."
 
Vol 7, No 1 (2015) Outpatient management of patients with dyscirculatory encephalopathy Abstract  similar documents
V. A. Parfenov, D. V. Neverovsky
"... patient examination, including neuropsychological testing. Patients and methods. Fifty patients, including ..."
 
Vol 9, No 2 (2017) Optimization of the management of patients with nonspecific chronic low back pain Abstract  similar documents
E. Yu. Kalimeeva, V. A. Parfenov
"... The management of patients with chronic (>3-month) nonspecific pain in the lumbar region (low back ..."
 
Vol 13, No 4 (2021) Treatment of antipsychotic-induced parkinsonism in schizophrenic patients Abstract  similar documents
E. E. Vaiman, N. A. Shnayder, N. G. Neznanov, R. F. Nasyrova
"... of psychopharmacotherapy in patients with schizophrenia. Many studies have investigated various drugs that are used ..."
 
Vol 13, No 4 (2021) Medication adherence in migraine patients (data of an online survey) Abstract  similar documents
N. A. Kovalchuk, E. A. Kiryanova, G. R. Tabeeva
"... Patient needs, drug intake patterns, and adherence to therapy are significant challenges ..."
 
Vol 13, No 5 (2021) Management of patients with pain syndromes associated with COVID-19 Abstract  similar documents
L. T. Akhmedzhanova, T. M. Ostroumova, O. A. Solokha
"... is treated with non-steroidal anti-inflammatory drugs. However, using this drug class in patients with COVID ..."
 
Vol 15, No 2 (2023) Quality of life of patients with rheumatoid arthritis and comorbid fibromyalgia Abstract  similar documents
N. A. Melikova, E. S. Filatova, E. G. Filatova, A. M. Lila
"... ) of patients with rheumatoid arthritis (RA). Material and methods. The study involved 90 patients ..."
 
Vol 15, No 1 (2023) Adherence to treatment in patients with cerebrovascular disease as a multifactorial problem Abstract  similar documents
M. M. Tanashyan, K. V. Antonova, O. V. Lagoda, A. A. Kornilova, E. P. Shchukina
"... The most important component of the treatment effectiveness is the adherence of patients ..."
 
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