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Clinical course features of atypical demyelinating optic neuritis: case series

https://doi.org/10.14412/2074-2711-2023-1S-35-42

Abstract

Optic neuritis (ON) can often occur at the onset of a demyelinating autoimmune CNS disease or as one of its clinical manifestations. The introduction of novel laboratory techniques, technical advances in magnetic resonance imaging (MRI), electrophysiologic studies, and ocular imaging have significantly expanded the spectrum of autoimmune optic neuropathies. Identification of different forms of ON based on clinical and instrumental data can lead to early diagnosis of the underlying neurologic disorder. According to current guidelines, one can distinguish between typical ON, which are mainly associated with multiple sclerosis (MS), and atypical ON, which are the main clinical manifestation of neuromyelitis optica spectrum disorders (NMOSD) and diseases associated with myelin oligodendrocyte glycoprotein antibodies (MOGAD). In this paper, we present four clinical cases of atypical ON at the onset of NMOSD and MOGAD and illustrate the high diagnostic value of a multidisciplinary approach.

About the Authors

N. L. Sheremet
M.M. Krasnov Research Institute of Eye Diseases
Russian Federation

Nataliya Leonidovna Sheremet

11А, Б, Rossolimo St., Moscow 119021



D. D. Eliseeva
Research Center of Neurology
Russian Federation

80, Volokolamskoe Shosse, Moscow 125367



V. V. Bryukhov
Research Center of Neurology
Russian Federation

80, Volokolamskoe Shosse, Moscow 125367



N. A. Andreeva
M.M. Krasnov Research Institute of Eye Diseases
Russian Federation

11А, Б, Rossolimo St., Moscow 119021



N. V. Zhorzholadze
M.M. Krasnov Research Institute of Eye Diseases
Russian Federation

11А, Б, Rossolimo St., Moscow 119021



Yu. K. Murakhovskaya
M.M. Krasnov Research Institute of Eye Diseases
Russian Federation

11А, Б, Rossolimo St., Moscow 119021



A. K. Kalashnikova
Department of Nervous System Diseases and Neurosurgery, I.M. Sechenov First Moscow State Medical University, Ministry of Health of Russia (Sechenov University)
Russian Federation

11А, Б, Rossolimo St., Moscow 119021



M. N. Zakharova
Research Center of Neurology
Russian Federation

80, Volokolamskoe Shosse, Moscow 125367



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Review

For citations:


Sheremet NL, Eliseeva DD, Bryukhov VV, Andreeva NA, Zhorzholadze NV, Murakhovskaya YK, Kalashnikova AK, Zakharova MN. Clinical course features of atypical demyelinating optic neuritis: case series. Nevrologiya, neiropsikhiatriya, psikhosomatika = Neurology, Neuropsychiatry, Psychosomatics. 2023;15:35-42. (In Russ.) https://doi.org/10.14412/2074-2711-2023-1S-35-42

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ISSN 2074-2711 (Print)
ISSN 2310-1342 (Online)