Clinical course features of atypical demyelinating optic neuritis: case series
https://doi.org/10.14412/2074-2711-2023-1S-35-42
Abstract
Optic neuritis (ON) can often occur at the onset of a demyelinating autoimmune CNS disease or as one of its clinical manifestations. The introduction of novel laboratory techniques, technical advances in magnetic resonance imaging (MRI), electrophysiologic studies, and ocular imaging have significantly expanded the spectrum of autoimmune optic neuropathies. Identification of different forms of ON based on clinical and instrumental data can lead to early diagnosis of the underlying neurologic disorder. According to current guidelines, one can distinguish between typical ON, which are mainly associated with multiple sclerosis (MS), and atypical ON, which are the main clinical manifestation of neuromyelitis optica spectrum disorders (NMOSD) and diseases associated with myelin oligodendrocyte glycoprotein antibodies (MOGAD). In this paper, we present four clinical cases of atypical ON at the onset of NMOSD and MOGAD and illustrate the high diagnostic value of a multidisciplinary approach.
About the Authors
N. L. SheremetRussian Federation
Nataliya Leonidovna Sheremet
11А, Б, Rossolimo St., Moscow 119021
D. D. Eliseeva
Russian Federation
80, Volokolamskoe Shosse, Moscow 125367
V. V. Bryukhov
Russian Federation
80, Volokolamskoe Shosse, Moscow 125367
N. A. Andreeva
Russian Federation
11А, Б, Rossolimo St., Moscow 119021
N. V. Zhorzholadze
Russian Federation
11А, Б, Rossolimo St., Moscow 119021
Yu. K. Murakhovskaya
Russian Federation
11А, Б, Rossolimo St., Moscow 119021
A. K. Kalashnikova
Russian Federation
11А, Б, Rossolimo St., Moscow 119021
M. N. Zakharova
Russian Federation
80, Volokolamskoe Shosse, Moscow 125367
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Review
For citations:
Sheremet NL, Eliseeva DD, Bryukhov VV, Andreeva NA, Zhorzholadze NV, Murakhovskaya YK, Kalashnikova AK, Zakharova MN. Clinical course features of atypical demyelinating optic neuritis: case series. Nevrologiya, neiropsikhiatriya, psikhosomatika = Neurology, Neuropsychiatry, Psychosomatics. 2023;15:35-42. (In Russ.) https://doi.org/10.14412/2074-2711-2023-1S-35-42