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Russian Register of Pregnancy and Epilepsy

https://doi.org/10.14412/2074-2711-2017-1S-21-25

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Abstract

The use of antiepileptic drugs (AEDs) during pregnancy is associated with an increased risk of congenital malformations (CMF). Information on the teratogenicity of AEDs is contradictory. The potential negative effects of new-generation AEDs are less well known. Many physicians and patients face difficulties in establishing a balance between the risk of seizures during pregnancy and that of teratogenicity in the use of AEDs. In most foreign countries, there are national and international pregnancy and epilepsy registries that make possible to centralize and systematize information on the safety of AEDs and to also give a true picture of the state of the problem.

The Russian pregnancy and epilepsy register (RPER) has been launched since 2017. RPER is a Russian national prospective and retrospective observational study, without interfering with the antiepileptic therapy prescribed by an attending physician to childbearing-aged patients living in the subjects of the Russian Federation. RPER is an independent research initiative and is implemented by neurologists and psychiatrists who provide assistance to women with epilepsy. The main goal of the RPER is to compare the risk of serious CMFs following the maternal intake of various AEDs and their combinations in different regions of the Russian Federation and to develop strategies for preventing CMFs. 

About the Authors

D. V. Dmitrenko
Professor V.F. Voino-Yasenetsky Krasnoyarsk State Medical University, Ministry of Health of Russia
Russian Federation
1, Partisan Zheleznyak St., Krasnoyarsk 660022


N. A. Schnaider
Professor V.F. Voino-Yasenetsky Krasnoyarsk State Medical University, Ministry of Health of Russia
Russian Federation
1, Partisan Zheleznyak St., Krasnoyarsk 660022


A. N. Goroshkin
Academician M.F. Reshetnev Siberian State Aerospace University
Russian Federation
31, Krasnoyarsky Rabochiy Gazeta Prospect


A. I. Tomilina
Academician M.F. Reshetnev Siberian State Aerospace University
Russian Federation
31, Krasnoyarsky Rabochiy Gazeta Prospect


P. N. Vlasov
A.I. Evdokimov Moscow State University of Medicine and Dentistry
Russian Federation
20, Delegatskaya St., Build. 1, Moscow 127473


M. R. Sapronova
Professor V.F. Voino-Yasenetsky Krasnoyarsk State Medical University, Ministry of Health of Russia
Russian Federation
1, Partisan Zheleznyak St., Krasnoyarsk 660022


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For citation:


Dmitrenko D.V., Schnaider N.A., Goroshkin A.N., Tomilina A.I., Vlasov P.N., Sapronova M.R. Russian Register of Pregnancy and Epilepsy. Neurology, Neuropsychiatry, Psychosomatics. 2017;9(1S):21-25. (In Russ.) https://doi.org/10.14412/2074-2711-2017-1S-21-25

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ISSN 2074-2711 (Print)
ISSN 2310-1342 (Online)