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Sporadic cerebral non-amyloid microangiopathy: pathogenesis, diagnosis, and features of treatment policy

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The paper is devoted to the most common variant of cerebral small-vessel disease Р sporadic cerebral non-amyloid microangiopathy (SCNAMA) in the context of acute and chronic cerebral circulatory disorders. It highlights the topical issues of neuropathology and pathogenesis of the disease. The paper presents the current neuroimaging markers of SCNAMA with a detailed discussion of lacunar infarcts, cerebral microinfarctions, and microbleeds. It considers the clinical manifestations of the chronic form of the disease, including cognitive impairment. The problem in the differential diagnosis of SCNAMA and cerebral amyloid angiopathy is highlighted. The current possibilities of minimizing risks and improving the efficiency of treatment in this category of patients are discussed.

About the Authors

A. A. Kulesh
Acad. E.A. Vagner Perm State Medical University, Ministry of Health of Russia
Russian Federation

Aleksey Aleksandrovich Kulesh

Perm, 26, Petropavlovskaya St., Perm 614990

V. E. Drobakha
Acad. E.A. Vagner Perm State Medical University, Ministry of Health of Russia
Russian Federation

Perm, 26, Petropavlovskaya St., Perm 614990

V. V. Shestakov
Acad. E.A. Vagner Perm State Medical University, Ministry of Health of Russia
Russian Federation

Perm, 26, Petropavlovskaya St., Perm 614990


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For citations:

Kulesh A.A., Drobakha V.E., Shestakov V.V. Sporadic cerebral non-amyloid microangiopathy: pathogenesis, diagnosis, and features of treatment policy. Neurology, Neuropsychiatry, Psychosomatics. 2018;10(4):13-22. (In Russ.)

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