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The triple synergy of ethylmethylhydroxypyridine succinate, magnesium, and vitamin B6: Molecular mechanisms

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Objective: to evaluate the triple effect of ethylmethylhydroxypyridine succinate (EMHPS), organic magnesium salt (magnesium lactate), and vitamin B6 (pyridoxine).

Material and methods. A systematic analysis of the molecular mechanisms of the triple synergic action of EMHPS, magnesium, and vitamin B6 was carried out. For chemoinformational analysis, the investigators developed a new mathematical method based on the combinatorial theory of solvability, which allows one to obtain quantitative estimates of the affinity constants of proteome proteins.

Results. The pharmacological effects of the EMHPS molecule characterized by nootropic and antioxidant properties are shown to work in synergy with magnesium and vitamin B6. A systematic analysis of synergy interactions indicated 46 biological roles, in which the synergy of EMHPS, magnesium, and pyridoxine could be manifested. The main goals of this synergy are to protect neurons from damage, by combating excitotoxicity in the cells and to neutralize excess homocysteine (to reduce the risk of ischemic and thrombotic stroke, myocardial infarction, and coronary heart disease); to improve cognitive functions and neuromuscular transmission, to reduce anxiety, by activating acetylcholine, GABA, and dopamine receptors; to normalize lipid and glucose metabolism, by lowering hyperglycemia and improving the processing of fats.

About the Authors

O. A. Gromova
Ivanovo State Medical Academy, Ministry of Health of Russia
Russian Federation
8, Sheremetevsky Passage., Ivanovo 153000

A. G. Kalacheva
Ivanovo State Medical Academy, Ministry of Health of Russia
Russian Federation
8, Sheremetevsky Passage., Ivanovo 153000

I. Yu. Torshin
Moscow Institute of Physics and Technology
Russian Federation
9, Institutsky Lane, Dolgoprudnyi, Moscow Region 141700

T. R. Grishina
Ivanovo State Medical Academy, Ministry of Health of Russia
Russian Federation
8, Sheremetevsky Passage., Ivanovo 153000

I. K. Tomilova
Ivanovo State Medical Academy, Ministry of Health of Russia
Russian Federation
8, Sheremetevsky Passage., Ivanovo 153000


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For citation:

Gromova O.A., Kalacheva A.G., Torshin I.Y., Grishina T.R., Tomilova I.K. The triple synergy of ethylmethylhydroxypyridine succinate, magnesium, and vitamin B6: Molecular mechanisms. Neurology, Neuropsychiatry, Psychosomatics. 2017;9(1):42-49. (In Russ.)

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ISSN 2074-2711 (Print)
ISSN 2310-1342 (Online)