Systematic analysis of basic and clinical studies of etifoxine
https://doi.org/10.14412/2074-2711-2016-3-106-112
Abstract
The paper presents a systematic analysis of experimental and clinical studies of etifoxine. The anxiolytic effect of etifoxine is due, firstly, to the modulation of GABA receptor activity and, secondly, to that of metabolism of neurosteroids that are themselves characterized by anxiolytic and neuroprotective properties. The results of clinical trials of etifoxine are also analyzed. In addition to its anxiolytic effect that partially persists even after treatment discontinuation, etifoxine is ascertained to be characterized by analgesic, neurotrophic and neuroprotective properties.
About the Authors
I. Yu. Torshin
Moscow Institute of Physics and Technology, Dolgoprudnyi, Russia 9, Institutsky Lane, Dolgoprudnyi, Moscow Region 141700
Russian Federation
Russian Federation
O. A. Gromova
Ivanovo State Medical Academy, Ministry of Health of Russia, Ivanovo, Russia 8, Sheremetevsky Passage, Ivanovo 153000
Russian Federation
Russian Federation
V. A. Semenov
Kemerovo State Medical Academy, Ministry of Health of Russia, Kemerovo, Russia 22a, Voroshilov St., Kemerovo 650056
Russian Federation
Russian Federation
T. R. Grishina
Ivanovo State Medical Academy, Ministry of Health of Russia, Ivanovo, Russia 8, Sheremetevsky Passage, Ivanovo 153000
Russian Federation
Russian Federation
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Review
For citations:
Torshin IY, Gromova OA, Semenov VA, Grishina TR. Systematic analysis of basic and clinical studies of etifoxine. Nevrologiya, neiropsikhiatriya, psikhosomatika = Neurology, Neuropsychiatry, Psychosomatics. 2016;8(3):106-112. (In Russ.) https://doi.org/10.14412/2074-2711-2016-3-106-112
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