Epidemiology of multiple sclerosis in the Bryansk Region
Abstract
Objective: to study the clinical and epidemiological features of multiple sclerosis (MS) in the Bryansk Region.
Patients and methods. Information about 180 (31.0%) of 590 MS patients registered in the Bryansk Region with a valid diagnosis of MS according to the 2005 McDonald criteria was analyzed. All the patients are followed up at the Demyelinating Disease Office, Neurology Department, Bryansk Regional Hospital One. The Expanded Disability Status Scale (EDSS) was used to evaluate the severity of the disease and the degree of disability. The rate of MS progression was calculated from the ratio of EDSS scores at the time of examination to disease duration.
Results. The Bryansk Region is shown to belong to a moderate MS risk area: the prevalence of the disease is 48.1 cases per 100,000; its incidence in the individual districts of the region is 5.0 to 211.4 cases per 100,000. There has been an approximately 1.2-fold increase in the prevalence of MS in the past 7 years. The mean age of MS patients in the Bryansk Region is 39.9±10.1 years; about 70% of the patients are in the age range of 29–49 years. The mean age at the onset of MS is 28.0±9.1 years. Early-onset MS before the age of 18 years is recorded in 20 (11.1%) patients; late-onset MS (after the age of 45 years) is in 7 (3.9%). There is a preponderance of its multifocal onset. Sensitive and motor disorders and optic neuritis more frequently occur as the first symptom at monofocal onset. The duration of MS averages 11.0±5.5 years (1 to 32 years). The mean duration of the first remission is as long as 33.1±26.1 (0–144) months and that of the second one is 19.2±17.7 (0–132) months. The mean EDSS score was 3.3±2.4 (0–9.0). The rate of MS progression in the region averages 0.38±0.28 per year. About 60% of the patients have Groups I, II, and III disability. Remitting MS is more common (69.4% of cases), its secondary and primary progressive course is noted in 28.9% and in nearly 2% of the patients, respectively.
Conclusion. The findings may be useful in planning sociomedical care for patients with MS in some areas of the Bryansk Region.
About the Authors
Yu. N. Yurchenko
Bryansk Regional Hospital One, Bryansk, Russia 86, Stanke-Dimitrov Prosp., Bryansk 241033
Russian Federation
Russian Federation
A. N. Yurchenko
Bryansk Regional Hospital One, Bryansk, Russia 86, Stanke-Dimitrov Prosp., Bryansk 241033
Russian Federation
Russian Federation
I. V. Smagina
Altai State Medical University, Ministry of Health of Russia, Barnaul, Russia 40, Lenin Prosp., Barnaul, Altai Territory 656038
Russian Federation
Russian Federation
References
1. Гусев ЕИ, Бойко АН, Завалишин ИА. Эпидемиологическое исследование рассеянного склероза. Методические рекомендации МЗ РФ№2003/82. 2003. 80 c. [Gusev EI, Boiko AN, Zavalishin IA. Epidemiological study of multiple sclerosis. Methodical recommendations of MH RF No. 2003/82. 2003. 80 p.]
2. Завалишин ИА, Пирадов МА, Бойко АН и др. Аутоиммунные заболевания в неврологии. Москва: Здоровье человека; 2014. 592 с. [Zavalishin IA, Piradov MA, Boiko AN, et al. Autoimmunnye zabolevaniya v nevrologii [Autoimmune diseases in neurology]. Moscow: Zdorov'e cheloveka; 2014. 592 p.]
3. Kantarci O, Wingerchuk D. Epidemiology and natural history of multiple sclerosis: new insights. Curr Opin Neurol. 2006 Jun;19(3):248-54.
4. Смагина ИВ, Игнатова ЮН, Ельчанинова СА, Федянин АС. Распространенность и факторы риска рассеянного склероза в популяции Алтайского края. Бюллетень сибирской медицины. 2011;(2):39-42. [Smagina IV, Ignatova YuN, El'chaninova SA, Fedyanin AS. Prevalence and risk factors of multiple sclerosis in the population of the Altai territory. Byulleten' sibirskoi meditsiny. 2011;(2):39-42. (In Russ.)].
5. Кичерова ОА, Рейхерт ЛИ, Быченко СМ. Рассеянный склероз. Тюмень: Cити-пресс; 2007. 152 с. [Kicherova OA, Reikhert LI, Bychenko SM. Rasseyannyi skleroz [Multiple sclerosis]. Tyumen': Siti-press; 2007. 152 p.]
6. Poser CM, Paty DW, Scheinberg L, et al. New diagnostic criteria for multiple sclerosis: guidelines for reseach protocols. Ann Neurol. 1983 Mar;13(3):227-31.
7. McDonald WI, Compston A, Edan G, et al. Recommended Diagnostic criteria for Multiple sclerosis: Guidelines from the International Panel on the diagnosis of Multiple sclerosis. Ann Neurol. 2001 Jul;50(1):121-7.
8. Polman CH, Reingold SC, Edan C, et al. Diagnostic criteria for multiple sclerosis: 2005 revisions to the «McDonald Criteria». Ann Neurol. 2005 Dec;58(6):840-6.
9. Polman CH, Reingold SC, Banwell B, et al. Diagnostic criteria for multiple sclerosis: 2010 revisions to the McDonald criteria. Ann Neurol. 2011 Feb;69(2):292-302. doi: 10.1002/ana.22366.
10. Kurtzke JF. Rating neurologic impairment in multiple sclerosis: an expanded disability status scale (EDSS). Neurology. 1983 Nov;33(11):1444-52.
11. Малкова НА, Иерусалимский АП. Рассеянный склероз. Новосибирск: Новосибирский медицинский университет; 2006. 198 с. [Malkova NA, Ierusalimskii AP. Rasseyannyi skleroz [Multiple sclerosis]. Novosibirsk: Novosibirskii meditsinskii universitet; 2006. 198 p.]
12. Худякова ИВ, Грибова НП. Клинико-эпидемиологические и биорадикальные аспекты рассеянного склероза города Брянска. Нейроиммунология. 2009;7(1):24. [Khudyakova IV, Gribova NP. Clinical, epidemiological and bioradical aspects of multiple sclerosis in the city of Bryansk. Neiroimmunologiya. 2009;7(1):24. (In Russ.)].
13. Гусев ЕИ, Демина ТЛ, Бойко АН. Рассеянный склероз. Москва: Медицина; 1997. 463 с. [Gusev EI, Demina TL, Boiko AN. Rasseyannyi skleroz [Multiple sclerosis]. Moscow: Meditsina; 1997. 463 p.]
14. Lauer K, Finharber W. Descripitive and analytical epidemiological data on multiple sclerosis from a long term study in Southern Hesse, Germany. Multiple Sclerosis in Europe: Epidemiological Update. 1994. P. 14-27.
Review
For citations:
Yurchenko Yu.N., Yurchenko A.N., Smagina I.V. Epidemiology of multiple sclerosis in the Bryansk Region. Neurology, Neuropsychiatry, Psychosomatics. 2016;8(3):31-33. (In Russ.) https://doi.org/10.14412/2074-2711-2016-3-31-33
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