Preview

Neurology, Neuropsychiatry, Psychosomatics

Advanced search

Correction of affective and cognitive disorders in epileptic patients and the value of lamotrigine

https://doi.org/10.14412/2074-2711-2013-2418

Abstract

The paper characterizes an association of cognitive and affective disorders in epilepsy, which may be a cause of worse quality of life, social dysadaptation, and disability. In this connection, it is imperative to choose correct antiepileptic drugs (AEDs). Groups of AEDs with different modes of action are considered, among which, lamotrigine that is noted for its unique profile of not only antiepileptic, but also psychotropic properties is given much attention.

About the Author

Vladimir Veniaminovich Kalinin

Department of Exogenous Organic Disorders and Epilepsy


References

1. <div><p>Brodie M.J., Shorvon S.D., Canger R. et al. Commission on European Affairs: appropriate standards of epilepsy care across Europe. Epilepsia 1997;38:1245—50.</p><p>Farwell J., Lee Y., Hirtz D. et al. Phenobarbital for febrile seizures — effects on intelligence and on seizures recurrence. N Engl J Med 1990;322:364—9.</p><p>Schneider F., Habel U., Bestman S. Affektive Stö rungen. In: Frontalhirn, Funktionen und Erkrankungen. H. Fö rstl (Hrsg). Heidelberg, Springer, 2005;233—65.</p><p>Barry J., Lembke A., Huynh N. Affective disorders in epilepsy. In: Psychiatric issues in epilepsy. A practical guide to diagnosis and treatment. A. Ettinger, A. Kanner (eds). Philadelphia, LWW, 2001;45—71.</p><p>Blumer D. Dysphoric disorders and paroxys mal affects: recognition and treatment of epilepsy-related psychiatric disorders. Harvard Rev Psychiatry 2000;8:8—17.</p><p>Blumer D. Epilepsy and suicide: a neuropsychiatric analysis. In: The neuropsychiatry of epilepsy. M.Trimble, B.Schmitz (eds). Cambridge, 2002;107—16.</p><p>Blumer D., Altschuler L.L. Affective disorders. In: Epilepsy: a comprehensive textbook. J. Engel, T.A. Pedley (eds). Philadelphia: Lipрincott Raven, 1998;2083—99.</p><p>Dalby M.A. Antiepileptic and psychotropic effect of carbamazepine (Tegretol) in the treatment of psychomotor epilepsy. Epilepsia 1971;12:325—34.</p><p>Damasio A., Anderson S. The frontal lobes. In: Clinical Neuropsychology. K.M. Heilman, E. Valenstein. Oxford: University Press, 2003;404—46.</p><p>Kalinin V.V. Suicidality and antiepileptic drugs. Is there a link? Drug Saf 2007;30(2):123—42.</p><p>Kalinin V.V., Polyanskiy D.A. Focus laterality and interictal psychiatric disorder in temporal lobe epilepsy. Seizure 2009;18(3):176—79.</p><p>Kalvianen R., Salmenpera T., Partanen K. et al. Recurrent seizures may cause hippocampal damage in temporal lobe epilepsy. Neurology 1998;50:1377—82.</p><p>Kanemoto K. Postictal psychoses, revised. In: The neuropsychiatry of epilepsy. M. Trimble, B. Schmitz (eds). Cambridge, 2002;117—31.</p><p>Bech P., Pedersen K., Simonsen N. et al. Personality in epilepsy. Acta Neurol Scand 1976;54:348-58.</p><p>Benson D. The Geshwind syndrome. In: Advances in Neurology. D. Smith, D. Treiman, M. Trimble (eds). N.Y., 1999;55:421-41.</p><p>Berg E.A. A simple objective technique for measuring flexibility in thinking. J Genet Psychol 1948;39:15-22.</p><p>Bergin P., Thomson P., Baxendale S. et al. Remote memory in epilepsy. Epilepsia 2000;41(2):231—39.</p><p>Besag F.M. Behavioral effect of the new anticonvulsants. Drug Saf 2000;24:513—36.</p><p>Besag F. Subtle cognitive and behavioral effect of epilepsy. In: The neuropsychiatry of epilepsy. M. Trimble, B. Schmitz (eds). Cambridge: University Press, 2002;70-80.</p><p>Gilliam F.G., Santos J., Vahle V. et al. Depression in epilepsy: Ignoring clinical expression of neuronal network dysfunction? Epilepsia 2004;46(Suppl 2):28-33.</p><p>Devinsky O. Therapy for neurobehavioral disorders in epilepsy. Epilepsia 2004;45(Suppl 2):34-40.</p><p>Hirsch E., Schmitz B., Carreno M. Epilepsy, antiepileptic drugs (AEDs) and cognition. Acta Neurol Scand 2003;108(Suppl 180):23—32.</p><p>Kanner A. Recognition of the various expressions of anxiety, psychosis, and aggressionin epilepsy. Epilepsia 2004;45(Suppl 2):22-7.</p><p>Калинин В.В., Железнова Е.В., Земляная А.А. Когнитивные нарушения при эпилепсии. Журн неврол и психиатр. Прил 1. Эпилепсия 2006;64-70.</p><p>Hermann B., Wyler A., Richey E. et al. Memory function and verbal learning ability in patients with complex partial seizures of temporal lobe origin. Epilepsia 1987;28:547-54.</p><p>Meador K., Loring D. Cognitive effects of antiepileptic drugs. In: Epilepsy and behavior. O. Devinsky, W. Theodore (eds). N.Y., 1991;151-70.</p><p>Parnas J., Flachs H., Gram L. Psychotropic effect of antiepileptic drugs. Acta Neurol Scand 1979;60:329-43.</p><p>Devinsky O., D’Esposito M. Neurology of cognitive and behavioral disorders. Oxford: University Press, 2004;451p.</p><p>Aldenkampf A.P. Antiepileptic drug treatment and epileptic seizure effect on cognitive function. In: The Neuropsychiatry of Epilepsy. M. Trimble and B. Schmitz (eds). Cambridge: Cambridge University Press, 2002;256-67.</p><p>Aldenkampf A.P., de Krom M., Reijs R. Newer antiepileptic drugs and cognitive issues. Epilepsia 2003;44(Suppl 4):21-9.</p><p>Bourgeois B. Antiepileptic drugs, learning, and behavior in childhood epilepsy. Epilepsia 1998;39(9):913—21.</p><p>Brodie M., McPhail E., MacPhee G. et al. Psychomotor impairment and anticonvulsant therapy in adult epileptic patients. Eur J Clin Pharmacol 1987;31:655-60.</p><p>Brodie M.J., Richens A., Yuen A.W. for the UK Lamotrigine/Carbamazepine Monotherapy Trial Group. Double blind comparison of lamotrigine and carbamazepine in newly diagnosed epilepsy. Lancet 1995;345:476-9.</p><p>Edwards K.R., Sackellares J.C. Vuong A. et al. Lamotrigine monotherapy improves depressive symptoms in epilepsy: a double-blind comparison with valproate. Epilepsy Behav 2001;2:28-36.</p><p>Kockelmann E., Elger C.E., Helmstaedter C. Cognitive profile of topiramate as compared with lamotrigine in epilepsy patients on antiepileptic drug polytherapy: relationships to blood serum levels and comedication. Epilepsy Behav 2004;5:716-21.</p><p>Landolt H. Psychische Stö rungen bei Epilepsie. Klinische und elektroenzephalographische Untersuchungen. Dtsch med Wschr 1962;87:446-52.</p><p>MacLeod C., Dekaban A., Hunt E. Memory impairment in epileptic patients: selective effects of Phenobarbital concentration. Science 1978;202:1102-04.</p><p>Schmitz B. Depression and mania in patients with epilepsy. Epilepsia 2005;46(Suppl 4):45—9.</p><p>Schmitz B. Depressive disorders in epilepsy. In: Seizures, affective disorders and anticonvulsant drugs. M. Trimble and B.Schmitz ^ds). Guildford: Clarius Press Ltd, 2002;19-34.</p><p>MacDonald R.L. Carbamazepine mechanisms of action. In: Antiepileptic Drugs. 5th ed. R.H. Levy, R.H. Mattson, B. Meldrun, E. Perucca (eds). Philadelphia.: LWW, 2002;227-35.</p><p>Fakhoury T.A., Barry J.J., Miller M. et al. Lamotrigine in patients with epilepsy and comorbid depressive symptoms. Epilepsy Behav 2007;10:155-62.</p><p>Folstein M.F., Folstein S.E., McHugh P.R. «Mini-mental state». A practical method for grading the cognitive state of patients for the clinician. J Psychiatry Res 1975;12:189-98.</p><p>Perrine K., Kiolbasa T. Cognitive deficits in epilepsy and contribution to psychopathology. Neurology 1999;53(Suppl 2):39-48.</p><p>Quiske A., Helmstaedter C., Lux S. et al. Depression in patients with temporal lobe epilepsy is related to mesial temporal sclerosis. Epilepsy Res 2000;39:121-5.</p><p>Leach M.J., Randall A.D., Stefani A. et al. Lamotrigine. Mechanisms of action. In: Antiepileptic Drugs. 5th ed. R.H. Levy, R.H. Mattson, B. Meldrun, E. Perucca (eds). Philadelphia: LWW, 2002;363-69.</p><p>Mendez M.F., Cummings J.L., Benson D.F. et al. Depression in epilepsy: significance and phenomenology. Arch Neurol 1986;43:766-70.</p><p>Kanner A. Depression in neurological disorders. Lundbeck Institute, Cambridge Medical Communication Ltd, 2005;161p.</p><p>Kanner A. Recognition of the various expressions of anxiety, psychosis, and aggression in epilepsy. Epilepsia 2004;45(Suppl 2):22-7.</p><p>Kanner A., Nieto J. Depressive disorders in epilepsy. Neurology 1999;53(Suppl 2):26-32.</p><p>Herman B.P. Seidenberg M., Haltiner A. et al. Mood state in unilateral temporal lobe epilepsy. Biol Psychiatry 1991;30:1205-18.</p><p>Altschuler L.L., Devinsky O., Post R.M., Theodore W. Depression, anxiety and temporal lobe epilepsy: laterality of focus and symptomatology. Arch Neurol 1990;47:284-88.</p><p>Austin M.P., Mitchell P., Wilhelm K. et al. Cognitive function in depression: a distinct frontal impairment in melancholia? Psychol Med 1999;29:73-85.</p><p>Castellon S.A., Hinkin C.H., Satz P. Behavioral disorders associated with central nervous system dysfunction. In: Comprehensive handbook of psychopathology, 3rd ed. H.E. Adams, P.B. Sutker (eds). New York: Springer, 2004;813-40.</p><p>Smith D., Baker G., Davies G. et al. Outcomes of add-on treatment with lamotrigine in partial epilepsy. Epilepsia 1993;34:312-22.</p><p>Ketter T.A., Post R.M., Theodore W.H. Positive and negative psychiatric effects of antiepileptic drugs in patients with seizure disorders. Neurology 1999;53(Suppl 2):53—67.</p><p>Aldenkampf A.P., Mulder O.G., Overweg J. Cognitive effects of lamotrigine as first-line add-on in patients with localization-related (partial) epilepsy. J Epilepsy 1997;10:117-21.</p><p>Romberg H. A manual of the nervous diseases of man. Translated by H. Sieveking. London: Sydenham Society, 1853;203 p.</p><p>Southam E., Kirkby D., Higgins G.A. et al. Lamotrigine inhibits monoamine uptake in vitro and modulates 5-hydroxytryptamine uptake in rats. Eur J Pharmacol 1998;358:19-24.</p><p>Ortinski P., Meador K.J. Cognitive side effects of antiepileptic drugs. Epilepsy Behav 2004;5(Suppl 1):60-5.</p><p>Reijs R., Aldenkampf A.P., de Krom M. Mood effects of antiepileptic drugs. Epilepsy Behav 2004;5(Suppl 1):66-76.</p><p>Cramer J.A., Hammer A.E., Kustra R.P. Improved mood states with lamotrigine in patients with epilepsy. Epilepsy Behav 2004;5:702-7.</p><p>Cramer J.A., Hammer A.E., Kustra R.P. Quality of life improvement with conversion to lamotrigine monotherapy. Epilepsy Behav 2004;5:224-30.</p><p>Ettinger A.B., Kustra R.P., Hammer A.E. Effect of lamotrigine on depressive symptoms in adult patients with epilepsy. Epilepsy Behav 2007;10:148-54.</p><p>Walker M.C., Sander J.W. New anti-epileptic drugs. Exp Opin Invest Drug 1999;8:1497-510.</p></div><br />


Review

For citations:


Kalinin VV. Correction of affective and cognitive disorders in epileptic patients and the value of lamotrigine. Nevrologiya, neiropsikhiatriya, psikhosomatika = Neurology, Neuropsychiatry, Psychosomatics. 2013;5(2):78-83. (In Russ.) https://doi.org/10.14412/2074-2711-2013-2418

Views: 1066


Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 License.


ISSN 2074-2711 (Print)
ISSN 2310-1342 (Online)