Effective neuroprotection and organ protection: activation of the endogenous mechanisms of sanogenesis
https://doi.org/10.14412/2074-2711-2020-3-123-127
Abstract
The review sets out modern ideas about the mechanisms of action of gamma-aminobutyric acid (GABA) in the central nervous system and other organs and systems. Current experimental and clinical studies have shown that GABA has numerous effects: neuroprotective, antihypertensive, antidiabetic, antitumor, anti-inflammatory, antimicrobial, anti-allergic, hepatoprotective, nephroprotective and enteroprotective, and others, which are currently the subject for study by biologists, physiologists, and physicians. Synthetic GABA analogues are widely used in clinical practice. One of these drugs is aminophenylbutyric acid hydrochloride (Anvifen®) that has demonstrated high efficiency and safety in clinical practice.
Keywords
gamma-aminobutyric acid,
aminophenylbutyric acid hydrochloride,
Anvifen®,
neuroprotection,
cytoprotection
Supporting agencies: This article has been supported by Sotex PharmFirma. The sponsor has participated in the development of the investigation project and supported the investigation program, as well as in the decision to submit the article for publication.
About the Authors
R. G. Esin
Kazan State Medical Academy, Branch, Russian Medical Academy of Continuing Professional Education, Ministry of Health of Russia; Kazan (Volga) Federal University, Ministry of Education and Science of Russia
Russian Federation
Competing Interests:
Russian Federation
Radiy Germanovich Esin.
11, Mushtari St., Kazan 420012; 18, Kremlevskaya St., Kazan 420008.
Competing Interests:
The conflict of interest has not affected the results of the investigation. The authors are solely responsible for submitting the final version of the manuscript for publication. All the authors have participated in developing the concept of the article and in writing the manuscript. The final version of the manuscript has been approved by all the authors.
O. R. Esin
Kazan (Volga) Federal University, Ministry of Education and Science of Russia
Russian Federation
18, Kremlevskaya St., Kazan 420008.
Competing Interests:
Russian Federation
18, Kremlevskaya St., Kazan 420008.
Competing Interests:
The conflict of interest has not affected the results of the investigation. The authors are solely responsible for submitting the final version of the manuscript for publication. All the authors have participated in developing the concept of the article and in writing the manuscript. The final version of the manuscript has been approved by all the authors.
A. R. Khakimova
Kazan State Medical Academy, Branch, Russian Medical Academy of Continuing Professional Education, Ministry of Health of Russia
Russian Federation
Competing Interests:
Russian Federation
11, Mushtari St., Kazan 420012.
Competing Interests:
The conflict of interest has not affected the results of the investigation. The authors are solely responsible for submitting the final version of the manuscript for publication. All the authors have participated in developing the concept of the article and in writing the manuscript. The final version of the manuscript has been approved by all the authors.
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Review
For citations:
Esin RG, Esin OR, Khakimova AR. Effective neuroprotection and organ protection: activation of the endogenous mechanisms of sanogenesis. Nevrologiya, neiropsikhiatriya, psikhosomatika = Neurology, Neuropsychiatry, Psychosomatics. 2020;12(3):123-127. (In Russ.) https://doi.org/10.14412/2074-2711-2020-3-123-127
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