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Effective neuroprotection and organ protection: activation of the endogenous mechanisms of sanogenesis

https://doi.org/10.14412/2074-2711-2020-3-123-127

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Abstract

The review sets out modern ideas about the mechanisms of action of gamma-aminobutyric acid (GABA) in the central nervous system and other organs and systems. Current experimental and clinical studies have shown that GABA has numerous effects: neuroprotective, antihypertensive, antidiabetic, antitumor, anti-inflammatory, antimicrobial, anti-allergic, hepatoprotective, nephroprotective and enteroprotective, and others, which are currently the subject for study by biologists, physiologists, and physicians. Synthetic GABA analogues are widely used in clinical practice. One of these drugs is aminophenylbutyric acid hydrochloride (Anvifen®) that has demonstrated high efficiency and safety in clinical practice.

About the Authors

R. G. Esin
Kazan State Medical Academy, Branch, Russian Medical Academy of Continuing Professional Education, Ministry of Health of Russia; Kazan (Volga) Federal University, Ministry of Education and Science of Russia
Russian Federation

Radiy Germanovich Esin.

11, Mushtari St., Kazan 420012; 18, Kremlevskaya St., Kazan 420008.



O. R. Esin
Kazan (Volga) Federal University, Ministry of Education and Science of Russia
Russian Federation
18, Kremlevskaya St., Kazan 420008.


A. R. Khakimova
Kazan State Medical Academy, Branch, Russian Medical Academy of Continuing Professional Education, Ministry of Health of Russia
Russian Federation

11, Mushtari St., Kazan 420012.



References

1. Roberts E, Frankel S. Aminobutyric acid in brain: Its formation from glutamic acid. J Biol Chem. 1950 Nov;187(1):55-63.

2. Ngo DH, Vo TS. An Updated Review on Pharmaceutical Properties of GammaAminobutyric Acid. Molecules. 2019 Jul 24;24(15):2678. doi: 10.3390/mole-cules24152678.

3. Mann EO, Kohl MM, Paulsen O. Distinct roles of GABA(A) and GABA(B) receptors in balancing and terminating persistent cortical activity. J Neurosci. 2009 Jun 10;29(23):7513-7518. doi: 10.1523/JNEUROS(I.6162-08.2009.

4. Takano K, Yatabe MS, Abe A, et al. Characteristic expressions of GABA receptors and GABA producing/transporting molecules in rat kidney. PLoS One. 2014 Sep 4;9(9):e105835. doi: 10.1371/journal.pone.0105835. eCollection 2014.

5. Di Sabato DJ, Quan N, Godbout JP. Neuroinflammation: the devil is in the details. J Neurochem. 2016 Oct;139 Suppl 2(Suppl 2): 136-153. doi: 10.1111/jnc.13607.

6. Kaminsky N, Bihari O, Kanner S, Barzilai A. Connecting malfunctioning glial cells and brain degenerative disorders. Genomics Proteomics Bioinformatics. 2016 Jun;14(3):155-165. doi: 10.1016/j.gpb.2016.04.003. Epub 2016 May 28.

7. Bagli E, Goussia A, Moschos MM, Agnantis N, Kitsos G. Natural compounds and neuroprotection: Mechanisms of action and novel delivery systems. In Vivo. 2016;30:535-547.

8. Crowley T, Cryan JF, Downer EJ, O'Leary OF. Inhibiting neuroinflammation: The role and therapeutic potential of GABA in neuro-immune interactions. Brain Behav Immun. 2016 May;54:260-277. doi: 10.1016/j.bbi.2016.02.001. Epub 2016 Feb 3.

9. Wu C, Qin X, Du H, et al. The immunological function of GABAergic system. Frontiers in Bioscience (Landmark Edition). 2017 Mar;22:1162-1172. doi: 10.2741/4573.

10. Prud'homme GJ, Glinka Y, Wang Q. Immunological GABAergic interactions and therapeutic applications in autoimmune diseases. Autoimmun Rev. 2015 Nov;14(11): 1048-56. doi: 10.1016/j.autrev.2015.07.011. Epub 2015 Jul 29.

11. Cho YR, Chang JY, Chang HC. Production of gamma-aminobutyric acid (GABA) by Lactobacillus buchneri isolated from kimchi and its neuroprotective effect on neuronal cells. J Microbiol Biotechnol. 2007 Jan;17(1):104-9.

12. Li W, Wei M, Wu J, et al. Novel fermented chickpea milk with enhanced level of Y-amino-butyric acid and neuroprotective effect on P(12 cells. PeerJ. 2016 Aug 4;4:e2292. doi: 10.7717/peerj.2292. eCollection 2016.

13. Zhou C, Li C, Yu HM, et al. Neuroprotection of gamma-aminobutyric acid receptor agonists via enhancing neuronal nitric oxide synthase (Ser847) phosphorylation through increased neuronal nitric oxide synthase and PSD95 interaction and inhibited protein phosphatase activity in cerebral ischemia. J Neurosci Res. 2008 Oct;86(13):2973-83. doi: 10.1002/jnr.21728.

14. Liu L, Li CJ, Lu Y, et al. Baclofen mediates neuroprotection on hippocampal CA1 pyramidal cells through the regulation of autophagy under chronic cerebral hypoperfusion. Sci Rep. 2015 Sep 28;5:14474. doi: 10.1038/srep14474.

15. Wei XW, Yan H, Xu B, et al. Neuroprotection of co-activation of GABA receptors by preventing caspase-3 denitrosylation in KA-induced seizures. Brain Res Bull. 2012 Sep 1;88(6):617-23. doi: 10.1016/j.brain-resbull.2012.05.008. Epub 2012 May 18.

16. Okada T, Sugishita T, Murakami T, et al. Effect of the defatted rice germ enriched with GABA for sleeplessness, depression, autonomic disorder by oral administration. J Jpn Soc Food Sci. 2000;47(8):596-603. doi: 10.3136/nskkk.47.596

17. Chuang CY, Shi YC, You HP, et al. Antidepressant effect of GABA-rich monascus-fermented product on forced swimming rat model. J Agric Food Chem. 2011 Apr 13;59(7): 3027-34. doi: 10.1021/jf104239m. Epub 2011 Mar 4.

18. Yamatsu A, Yamashita Y, Pandharipande T, et al. Effect of oral Y-aminobutyric acid (GABA) administration on sleep and its absorption in humans. Food Sci Biotechnol. 2016 Apr 30; 25(2):547-551. doi: 10.1007/s10068-016-0076-9. eCollection 2016.

19. Kim S, Jo K, Hong KB, et al. GABA and l-theanine mixture decreases sleep latency and improves NREM sleep. Pharm Biol. 2019 Dec; 57(1):65-73. doi: 10.1080/13880209.2018.1557698.

20. Abdou AM, Higashiguchi S, Horie K, et al. Relaxation and immunity enhancement effect of gamma-aminobutyric acid (GABA) administration in humans. Biofactors. 2006;26(3): 201-8. doi: 10.1002/biof.5520260305.

21. Seo YC, Choi WY, Kim JS, et al. Enhancement of the cognitive effects of GABA from monosodium glutamate fermentation by Lactobacillus sakei B2-16. Food Biotechnol. 2012;26(1):29-44. doi: 10.1080/08905436.2011.645937

22. Reid SNS, Ryu JK, Kim Y, Jeon BH. The effects of fermented Laminaria japonica on short-term working memory and physical fitness in the elderly. Evid Based Complement Alternat Med. 2018 Sep 9;2018:1764038. doi: 10.1155/2018/1764038. eCollection 2018.

23. Reid SNS, Ryu JK, Kim YS, Jeon BH. GABA-enriched fermented Laminaria japonica improves cognitive impairment and neuroplasticity in scopolamine- and ethanol-induced dementia model mice. Nutr Res Pract. 2018 Jun;12(3):199-207. doi: 10.4162/nrp.2018.12.3.199. Epub 2018 Apr 25.

24. Choi WC, Reid SNS, Ryu JK, et al. Effects of Y-aminobutyric acid-enriched fermented sea tangle (Laminaria japonica) on brain derived neurotrophic factor-related muscle growth and lipolysis in middle aged women. Algae. 2016; 31(2):175-187. doi: 10.4490/algae.2016.31.6.12

25. Nejati F, Rizzello CG, Cagno RD, et al. Manufacture of a functional fermented milk enriched of angiotensin-I converting enzyme (ACE)-inhibitory peptides and Y-aminobutyric acid (GABA). Food Sci Technol. 2013;51(1): 183-9. doi: 10.1016/j.lwt.2012.09.017

26. Kimura M, Hayakawa K, Sansawa H. Involvement of gamma-aminobutyric acid (GABA) B receptors in the hypotensive effect of systemically administered GABA in spontaneously hypertensive rats. Jpn J Pharmacol. 2002 Aug;89(4):388-94. doi: 10.1254/jjp.89.388

27. Matsubara F, Ueno H, Kentaro T, et al. Effects of GABA supplementation on blood pressure and safety in adults with mild hypertension. Jpn Pharmacol Ther. 2002;30:963-72.

28. Nishimura M, Yoshida S, Haramoto M, et al. Effects of white rice containing enriched gamma-aminobutyric acid on blood pressure. J Tradit Complement Med. 2015 Jan 8;6(1): 66-71. doi: 10.1016/j.jtcme.2014.11.022. eCollection 2016 Jan.

29. Becerra-Tomas N, Guasch-Ferre M, Quilez J, et al. Effect of functional bread rich in potassium, Y-aminobutyric acid and angiotensin-converting enzyme inhibitors on blood pressure, glucose metabolism and endothelial function: A double-blind randomized crossover clinical trial. Medicine (Baltimore). 2015 Nov;94(46):e1807. doi: 10.1097/MD.0000000000001807.

30. Ngo DH, Vo TS. An Updated Review on Pharmaceutical Properties of GammaAminobutyric Acid. Molecules. 2019 Jul 24; 24(15):2678. doi: 10.3390/molecules24152678.

31. Soltani N, Qiu H, Aleksic M, et al. GABA exerts protective and regenerative effects on islet beta cells and reverses diabetes. Proc Natl Acad Sci U S A. 2011 Jul 12;108(28):11692-7. doi: 10.1073/pnas.1102715108. Epub 2011 Jun 27.

32. Untereiner A, Abdo S, Bhattacharjee A, et al. GABA promotes в-cell proliferation, but does not overcome impaired glucose homeostasis associated with diet-induced obesity. FASEB J. 2019 Mar;33(3):3968-3984. doi: 10.1096/fj.201801397R. Epub 2018 Dec 3.

33. Bansal P, Wang S, Liu S, et al. GABA coordinates with insulin in regulating secretory function in pancreatic INS-1 в-cells. PLoS One. 2011;6(10):e26225. doi: 10.1371/journal.pone.0026225. Epub 2011 Oct 21.

34. Liu W, Son DO, Lau HK, et al. Combined oral administration of GABA and DPP-4 inhibitor prevents beta cell damage and promotes beta cell regeneration in mice. Front Pharmacol. 2017 Jun 20;8:362. doi: 10.3389/fphar.2017.00362. eCollection 2017.

35. Tian J, Dang HN, Yong J, et al. Oral treatment with Y-aminobutyric acid improves glucose tolerance and insulin sensitivity by inhibiting inflammation in high fat diet-fed mice. PLoS One. 2011;6(9):e25338. doi: 10.1371/journal.pone.0025338. Epub 2011 Sep 22.

36. Huang CY, Kuo WW, Wang HF, et al. GABA tea ameliorates cerebral cortex apoptosis and autophagy in streptozotocin-induced diabetic rats. J Funct Foods. 2014;6:534-544. doi: 10.1016/j.jff.2013.11.020

37. Hagiwara H, Seki T, Ariga T. The effect of pre-germinated brown rice intake on blood glucose and PAI-1 levels in streptozotocin-induced diabetic rats. Biosci Biotechnol Biochem. 2004 Feb;68(2):444-7. doi: 10.1271/bbb.68.444.

38. Adamu HA, Imam MU, Ooi DJ, et al. Perinatal exposure to germinated brown rice and its gamma amino-butyric acid-rich extract prevents high fat diet-induced insulin resistance in first generation rat offspring. Food Nutr Res. 2016 Feb 2;60:30209. doi: 10.3402/fnr.v60.30209. eCollection 2016.

39. Ito Y, Mizukuchi A, Kise M, et al. Postprandial blood glucose and insulin responses to pre-germinated brown rice in healthy subjects. J Med Invest. 2005 Aug;52(3-4):159-64. doi: 10.2152/jmi.52.159.

40. Hsu TF, Kise M, Wang MF, et al. Effects of pre-germinated brown rice on blood glucose and lipid levels in free-living patients with impaired fasting glucose or type 2 diabetes. J Nutr Sci Vitaminol (Tokyo). 2008 Apr;54(2): 163-8. doi: 10.3177/jnsv.54.163.

41. Hayakawa T, Suzuki S, Kobayashi S, et al. Effect of pre-germinated brown rice on metabolism of glucose and lipid in patients with diabetes mellitus type 2. J Jpn Assoc Rural Med. 2009;58(4):438-446. doi: 10.2185/jjrm.58.438

42. Lukushkina EF, Karpovich EI, Chaban OD. Amino-phenylbutyric acid (Anvifen): clinical and pharmacological aspects and experience in pediatric neurology. Russkii meditsinskii zhurnal. 2014;(1):1-4. (In Russ.).

43. Zykov VP, Komarova IB. The possibility of using aminophenylbutyric acid in the practice of a pediatric neurologist. Russkii meditsinskii zhurnal. 2013;(24):1166-8. (In Russ.).

44. Esin RG, Esin OR, Shamsutdinova RF. Modern approaches to the correction of maladaptive (psycho-vegetative) disorders in children and adolescents with tension headaches. Pediatriya. Zhurnal im. G.N. Speranskogo. 2015;94(1):106-12. (In Russ.).

45. Esin OR. Treatment of Tension-Type Headaches in Adolescents (14—15 Years Old): the Efficacy of Aminophenylbutyric Acid Hydrochloride. BioNanoScience. 2018;8(1): 418-22. doi:10.1007/s12668-018-0507-6

46. Esin OR, Khairullin IK, Esin RG, Tokareva NV. Tension type headache: GABA-ergic drug anvifen efficacy. Zhurnal nevrologii i psikhiatrii im. S.S. Korsakova. 2016;116(2): 58-61. (In Russ.).

47. Esin RG, Khairullin IK, Mukhametova ER, Esin OR. Persistent postural-perceptual dizziness. Zhurnal nevrologii i psikhiatrii im. S.S. Korsakova. 2017;117(4):28-33 (In Russ.).


For citation:


Esin R.G., Esin O.R., Khakimova A.R. Effective neuroprotection and organ protection: activation of the endogenous mechanisms of sanogenesis. Neurology, Neuropsychiatry, Psychosomatics. 2020;12(3):123-127. (In Russ.) https://doi.org/10.14412/2074-2711-2020-3-123-127

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ISSN 2074-2711 (Print)
ISSN 2310-1342 (Online)