Антидепрессанты - ингибиторы обратного захвата серотонина и норадреналина: взгляд через призму 30-летней истории

На основании анализа данных литературы впервые подробно систематизированы основные этапы создания и введения в клиническую практику антидепрессантов — ингибиторов обратного захвата серотонина и норадреналина (ИОЗСН). Описаны теоретические предпосылки для их появления. В историческом контексте проанализирована оценка эффективности терапии депрессии препаратами этой группы на этапе клинических испытаний и в постмаркетинговый период. Рассмотрены причины временного введения ограничений для их широкого использования. Представлены данные о создании новых представителей антидепрессантов — ИОЗСН.

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