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Hemorrhagic manifestations of cerebral amyloid angiopathy: from pathogenesis to clinical significance

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The paper characterizes the neuropathological aspects of cerebral amyloid angiopathy (CAA) and its pathogenesis. It presents in detail the current neuroimaging markers of CAA and their neuropathological correlates. The phenotypic heterogeneity of the disease and its main clinical manifestations are considered; the updated Boston diagnostic criteria are formulated. The issues of intracerebral hemorrhages, cerebral microbleeding, and cortical superficial siderosis, which are associated with CAA, are elucidated in detail. CAA is noted to be of clinical significance for the determination of therapeutic policy in hemorrhagic stroke, systemic thrombolytic therapy, and cognitive impairment.

About the Authors

A. A. Kulesh
Acad. E.A. Vagner Perm State Medical University, Ministry of Health of Russia, Perm
Russian Federation

V. E. Drobakha
Acad. E.A. Vagner Perm State Medical University, Ministry of Health of Russia, Perm
Russian Federation

V. V. Shestakov
Acad. E.A. Vagner Perm State Medical University, Ministry of Health of Russia, Perm
Russian Federation


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For citations:

Kulesh A.A., Drobakha V.E., Shestakov V.V. Hemorrhagic manifestations of cerebral amyloid angiopathy: from pathogenesis to clinical significance. Neurology, Neuropsychiatry, Psychosomatics. 2018;10(3):4-11. (In Russ.)

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