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Неврология, нейропсихиатрия, психосоматика

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Геморрагические проявления церебральной амилоидной ангиопатии – от патогенеза к клиническому значению

https://doi.org/10.14412/2074-2711-2018-3-4-11

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Аннотация

Охарактеризованы нейропатологические аспекты церебральной амилоидной ангиопатии (ЦАА) и ее патогенез. Подробно представлены современные нейровизуализационные маркеры ЦАА и их нейропатологические корреляты. Рассмотрены фенотипическая гетерогенность заболевания и его основные клинические проявления, обновленные Бостонские диагностические критерии. Детально освещены вопросы внутримозговых кровоизлияний, церебральных микрокровоизлияний и коркового поверхностного сидероза, ассоциированных с ЦАА. Отмечено клиническое значение ЦАА для определения лечебной тактики при геморрагическом инсульте, системной тромболитической терапии и когнитивных нарушениях.

Об авторах

А. А. Кулеш
ФГБОУ ВО «Пермский государственный медицинский университет им. акад. Е.А. Вагнера» Минздрава России, Пермь
Россия


В. Е. Дробаха
ФГБОУ ВО «Пермский государственный медицинский университет им. акад. Е.А. Вагнера» Минздрава России, Пермь
Россия


В. В. Шестаков
ФГБОУ ВО «Пермский государственный медицинский университет им. акад. Е.А. Вагнера» Минздрава России, Пермь
Россия


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Для цитирования:


Кулеш А.А., Дробаха В.Е., Шестаков В.В. Геморрагические проявления церебральной амилоидной ангиопатии – от патогенеза к клиническому значению. Неврология, нейропсихиатрия, психосоматика. 2018;10(3):4-11. https://doi.org/10.14412/2074-2711-2018-3-4-11

For citation:


Kulesh A.A., Drobakha V.E., Shestakov V.V. Hemorrhagic manifestations of cerebral amyloid angiopathy: from pathogenesis to clinical significance. Neurology, Neuropsychiatry, Psychosomatics. 2018;10(3):4-11. (In Russ.) https://doi.org/10.14412/2074-2711-2018-3-4-11

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ISSN 2074-2711 (Print)
ISSN 2310-1342 (Online)