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Role of melatonin in the treatment of depression

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Depression remains a serious problem despite the continuous stream of researches on the problems of affective disorders and the emergence of new antidepressants. About 80% of inpatients with depression and 70% of outpatients with this condition complain of sleep disorders. There are presently a few available hypotheses of the onset of depressive disorders. Prominent among them are neurotransmitter dysfunction hypotheses and chronobiological concepts (the presence of altered circadian rhythms mediated by melatonin). There is currently a wide range of drugs that are able to affect melatonin metabolism, amongst which there is agomelatine and fluvoxamine.

About the Author

O. V. Kotova
I.M. Sechenov First Moscow State Medical University
Russian Federation

Department of Autonomic Nervous System Pathology, Research Center



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For citation:

Kotova O.V. Role of melatonin in the treatment of depression. Neurology, Neuropsychiatry, Psychosomatics. 2011;3(2):85-88. (In Russ.)

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