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Magnetic resonance spectroscopy of the brain in the diagnosis of temporal lobe epilepsy

https://doi.org/10.14412/2074-2711-2018-1S-51-55

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Abstract

The temporal lobe is the most epileptogenic region of the brain. 90% of patients with temporal ictal epileptomorphic EEG activity have a variable long history of seizures. Magnetic resonance spectroscopy  (MRS) may be useful in identifying an epileptogenic focus in patients  with epilepsy without apparent structural pathology at neuroimaging.

Objective: to systematize the results of early studies on this issue.

Materials and methods. An electronic search was carried out in two English-language (Medline, PubMed) and one Russian-language (eLIBRARY.RU) databases. The search queries found  18,019 citations, by which 12 full-text articles were selected.

Results and discussion. The main criteria for the diagnosis of temporal lobe epilepsy by MRS is to lower the level of N-acetylaspartate (NAA), the ratio of NAA to creatinine + choline  (NAA/(Cr + Cho) in the brain region where there is neuronal death  or damage, as well as a change in the level of myo-inositol, the  elevated level of which indicates the presence of an epileptogenic  focus, while the decreased one shows the spread of pathological activity to the adjacent tissues.

Conclusion. This review will contribute to a better diagnosis of temporal lobe epilepsy, as well as to the intravital noninvasive detection of metabolic changes in the brain long before the development of structural pathology.

About the Authors

E. S. Solomatova
Prof. V.F. Voino-Yasenetsky Krasnoyarsk State Medical University, Ministry of Health of Russia
Russian Federation
1, Partisan Zheleznyak St., Krasnoyarsk, 660022


N. A. Shnaider
Prof. V.F. Voino-Yasenetsky Krasnoyarsk State Medical University, Ministry of Health of Russia V.M. Bekhterev National Medical Research Center, of Psychiatry and Neurology, Ministry of Health of Russia
Russian Federation

1, Partisan Zheleznyak St., Krasnoyarsk, 660022

3, Bekhterev St., Saint Petersburg 192019



A. A. Molgachev
Diagnostic and Treatment Center, S.M. Berezin International Institute of Biological Systems
Russian Federation
26, Kolomenskaya St., Build. 3, Krasnoyarsk 660037


D. V. Dmitrenko
Prof. V.F. Voino-Yasenetsky Krasnoyarsk State Medical University, Ministry of Health of Russia
Russian Federation
1, Partisan Zheleznyak St., Krasnoyarsk, 660022


I. G. Strotskaya
Prof. V.F. Voino-Yasenetsky Krasnoyarsk State Medical University, Ministry of Health of Russia
Russian Federation
1, Partisan Zheleznyak St., Krasnoyarsk, 660022


References

1. Карлов ВА. Эпилепсия у детей и взрослых женщин и мужчин. Москва: Медицина; 2010. 720 c. [Karlov VA. Epilepsiya u detey i vzroslykh zhenshchin i muzhchin [Epilepsy in children and adult women and men]. Moscow: Medicine; 2010. 720 p. (In Russ.)].

2. Дмитренко ДВ, Строганова МА, Шнайдер НА и др. Гистологическая классификация мезиального темпорального склероза. Неврология, нейропсихиатрия, психосоматика. 2016;8(2):74-9 [Dmitrenko DV, Stroganova MA, Shnayder NA, et al. Histological classification of mesial temporal sclerosis. Nevrologiya, Neiropsikhiatriya, Psikhosomatika = Neurology, Neuropsychiatry, Psychosomatics. 2016;8(2):74-9 (In Russ.)]. doi: 10.14412/2074-2711-2016-2-74-79

3. Шнайдер НА, Дмитренко ДВ, Батухтин ЕН, Молгачев АА. Современные методы нейровизуализации в диагностике эпилепсии. Красноярск; 2007. 102 с. [Shnayder NA, Dmitrenko DV, Batuhtin EN, Molgachev AA. Sovremennye metody neyrovizualizatsii v diagnostike epilepsii [Modern methods of neuroimaging in the diagnosis of epilepsy]. Krasnoyarsk; 2007. 102 p. (In Russ.)].

4. Kousi E, Tsougos I, Eftychia K. Novel frontiers of advanced neuroimaging. In: Proton magnetic resonance spectroscopy of the central nervous system. 2013 CC BY 3.0 license. doi: 10.5772/53892

5. Aun AA, Mostafa AA, Fotouh AM, et al. Role of magnetic resonance spectroscopy (MRS) in nonlesional temporal lobe epilepsy. Egypt J Radiol Nucl Med. 2016;47(1):217-31. doi: 10.1016/j.ejrnm.2015.09.008

6. Хоружик СА. Магнитно-резонансная спектроскопия при опухолях головного мозга (обзор литературы). Онкологический журнал. 2007;(3):51-62 [Horuzhik SA. Magnetic resonance spectroscopy for tumors of the brain (review). Onkologicheskiy Zhurnal = Oncological Journal. 2007;(3):51-62 (In Russ.)].

7. Окользин АВ. Магнитно-резонансная спектроскопия по водороду в характеристике опухолей головного мозга. Онкология. 2007;(8):132-51 [Okolzin AB. Magnetic resonance spectroscopy on hydrogen in the characteristics of brain tumors. Onkologiya = Oncology. 2007;(8):132-51 (In Russ.)].

8. Богданов АВ. Магнитно-резонансная спектроскопия (обзор литературы). Вестник Кыргызско-Российского Славянского Университета. 2016;16(3):151-6 [Bogdanov AV. Magnetic resonance spectroscopy (literature review). Vestnik Kyrgyzsko-Rossiyskogo Slavyanskogo Universiteta = Bulletin of the Kyrgyz-Russian Slavic University. 2016;16(3):151- 6 (In Russ.)].

9. Wellard RM, Briellmann RS, Prichard JW, et al. Myoinositol Abnormalities in Temporal Lobe Epilepsy. Epilepsia. 2003;44(6):815-21. doi: 10.1046/j.1528-1157.2003.44102.x

10. Maton B, Gilliam F, Sawrie S, et al. Correlation of scalp EEG and 1H-MRS metaboli abnormalities in temporal lobe epilepsy. Epilepsia. 2001;42(3):417-22. doi: 10.1046/j.1528-1157.2001.25999.x

11. Hammen T, Schwarz M, Doelken M, et al. 1H-MR spectroscopy indicates severity markers in temporal lobe epilepsy: correlations between metabolic alterations, seizures, and epileptic discharges in EEG. Epilepsia. 2007;48(2):263-9. doi: 10.1111/j.1528-1167.2006.00856.x

12. Mueller SG, Ebel A, Barakos J, et al. Widespread extrahippocampal NAA/(Cr+Cho) abnormalities in TLE with and without mesial temporal sclerosis. J Neurol. 2011;258(4):603- 12. doi: 10.1007/s00415-010-5799-6

13. Крылов ВВ, Гехт АБ, Трифонов ИС и др. Клинические рекомендации по предоперационному обследованию и хирургическому лечению пациентов с фармакорезистентными формами эпилепсии. Москва; 2015 [Krylov VV, Gekht AB, Trifonov IS, et al. Klinicheskie rekomendatsii po predoperatsionnomu obsledovaniyu i khirurgicheskomu lecheniyu patsientov s farmakorezistentnymi formami epilepsii [Clinical recommendations for preoperative examination and surgical treatment of patients with pharmaco-resistant forms of epilepsy]. Moscow; 2015 (In Russ.)].

14. Zhang J, Liu Q, Mei S, et al. Identifying the affected hemisphere with a multimodal approach in MRI-positive or negative, unilateral or bilateral temporal lobe epilepsy. Neuropsychiatr Dis Treat. 2014;10:71-81. doi: 10.2147/NDT.S56404

15. Pan JW, Kuzniecky RI. Utility of magnetic resonance spectroscopic imaging for human epilepsy. Quant Imaging Med Surg. 2015;5(2):313-22. doi: 10.3978/j.issn.2223-4292.2015.01.03

16. Шнайдер НА, Мартынова ГП, Строганова МА и др. Фебрильные приступы как триггер мезиального вмсочного склероза. Клинический случай. Проблемы женского здоровья. 2015;10(1):69-78 [Schnayder NA, Martynova GP, Stroganova MA, et al. Febrile seizures as a trigger for mesial sclerosis. Clinical case. Problemy Zhenskogo Zdorov'ya = Problems of Women's Health. 2015;10(1):69-78 (In Russ.)].


For citation:


Solomatova E.S., Shnaider N.A., Molgachev A.A., Dmitrenko D.V., Strotskaya I.G. Magnetic resonance spectroscopy of the brain in the diagnosis of temporal lobe epilepsy. Neurology, Neuropsychiatry, Psychosomatics. 2018;10(1S):51-55. (In Russ.) https://doi.org/10.14412/2074-2711-2018-1S-51-55

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ISSN 2074-2711 (Print)
ISSN 2310-1342 (Online)