CLIPPERS syndrome
https://doi.org/10.14412/2074-2711-2018-2-76-82
Abstract
CLIPPERS syndrome (Chronic Lymphocytic Inflammation with Pontine Perivascular Enhancement Responsive to Steroids) is a recently described rare disease affecting the central nervous system. It is characterized by subacute development of symptoms of lesions predominantly in the brain stem and cerebellum, by specific magnetic resonance imaging (MRI) changes, perivascular lymphocytic infiltration in the brain substance and a good response to glucocorticoid (GC) therapy. The paper describes CLIPPERS syndrome in a patient who has been followed up in a clinic for 10 years. During this period, different variants of clinical diagnosis have been considered. The final diagnosis was made only when comparing the clinical course and manifestations of the disease, MRI data, as well as the reaction to GC therapy and its discontinuation. Literature data and diagnostic criteria of this disease are presented.
About the Authors
T. E. Schmidt
I.M. Sechenov First Moscow State Medical University (Sechenov University), Ministry of Health of Russia
Russian Federation
Russian Federation
Contact: Tatiana Evgenyevna Shmidt
A.Ya. Kozhevnikov Clinic of Nervous System Diseases
11, Rossolimo St., Moscow 119021
I. N. Pronin
Academician N.N. Burdenko National Medical Research Center for Neurosurgery, Ministry of Health of Russia
Russian Federation
16, Fourth Tverskaya-Yamskaya St., Moscow 125047
Russian Federation
16, Fourth Tverskaya-Yamskaya St., Moscow 125047
K. Yu. Kazantsev
I.M. Sechenov First Moscow State Medical University (Sechenov University), Ministry of Health of Russia
Russian Federation
Russian Federation
A.Ya. Kozhevnikov Clinic of Nervous System Diseases
11, Rossolimo St., Moscow 119021
O. N. Voskresenskaya
I.M. Sechenov First Moscow State Medical University (Sechenov University), Ministry of Health of Russia
Russian Federation
Russian Federation
A.Ya. Kozhevnikov Clinic of Nervous System Diseases
11, Rossolimo St., Moscow 119021
I. V. Damulin
I.M. Sechenov First Moscow State Medical University (Sechenov University), Ministry of Health of Russia
Russian Federation
Russian Federation
A.Ya. Kozhevnikov Clinic of Nervous System Diseases
11, Rossolimo St., Moscow 119021
A. A. Aleksandrov
I.M. Sechenov First Moscow State Medical University (Sechenov University), Ministry of Health of Russia
Russian Federation
Russian Federation
A.Ya. Kozhevnikov Clinic of Nervous System Diseases
11, Rossolimo St., Moscow 119021
N. N. Yakhno
I.M. Sechenov First Moscow State Medical University (Sechenov University), Ministry of Health of Russia
Russian Federation
Russian Federation
A.Ya. Kozhevnikov Clinic of Nervous System Diseases
11, Rossolimo St., Moscow 119021
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Review
For citations:
Schmidt T.E., Pronin I.N., Kazantsev K.Yu., Voskresenskaya O.N., Damulin I.V., Aleksandrov A.A., Yakhno N.N. CLIPPERS syndrome. Neurology, Neuropsychiatry, Psychosomatics. 2018;10(2):76-82. (In Russ.) https://doi.org/10.14412/2074-2711-2018-2-76-82
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