Молекулярные механизмы глюкозамина сульфата при лечении дегенеративно-дистрофических заболеваний суставов и позвоночника: результаты протеомного анализа

Цель исследования – систематический анализ молекулярных механизмов действия хондропротектора Сустагард® Артро, производимого на основе микрокристаллической фармацевтической субстанции глюкозамина сульфата – ГС (Биоиберика, С.А.У., Испания).

Материал и методы. Систематический анализ молекулярных механизмов на основе данных литературы и протеомных баз данных посредством систем машинного обучения.

Результаты и обсуждение. ГС взаимодействует с рецепторами CD44, TLR4 и ICAM1 на поверхности хондроцитов, ингибирует провоспалительный транскрипционный фактор NF-кВ, цитокиновый сигнальный путь JAK/STAT, регулирует синтез IgA, миграцию лейкоцитов, активность рецепторов гематопоэтина и интерферонов.

Заключение. Полученные результаты указывают на молекулярные механизмы синергизма между глюкозамином и нестероидными противовоспалительными препаратами в терапии патологии хрящевой соединительной ткани. 

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