Molecular mechanisms of action of glucosamine sulfate in the treatment of degenerative-dystrophic diseases of the joints and spine: results of proteomic analysis
Abstract
Objective: to carry out a systems analysis of the molecular mechanisms of action of the chondroprotector Sustaguard® Arthro based on the microcrystalline pharmaceutical substance glucosamine sulfate (GS) manufactured by Bioiberica S.A.U. (Spain).
Material and methods. The systems analysis of the molecular mechanisms was based on literature data and proteomic databases through machine learning systems.
Results and discussion. GS interacts with the receptors CD44, TLR4, and ICAM1 on the surface of chondrocytes, inhibits the proinflammatory transcription factor NF-κB and the cytokine signaling pathway JAK/STAT, and regulates the synthesis of IgA, the migration of leukocytes, and the activity of hematopoietin and interferon receptors.
Conclusion. The findings indicate that there are molecular mechanisms of synergism between glucosamine and nonsteroidal anti-inflammatory drugs in the therapy of cartilage tissue pathology.
About the Authors
O. A. Gromova
Institute of Pharmacoinformatics, Federal Research Center «Informatics and Control», Russian Academy of Sciences
Russian Federation
Russian Federation
Contact: Olga Alekseevna Gromova
40, Vavilov St., Moscow 119333
I. Yu. Torshin
Institute of Pharmacoinformatics, Federal Research Center «Informatics and Control», Russian Academy of Sciences
Russian Federation
40, Vavilov St., Moscow 119333
Russian Federation
40, Vavilov St., Moscow 119333
A. M. Lila
V.A. Nasonova Research Institute of Rheumatology
Russian Federation
34A, Kashirskoye Shosse, Moscow 115552
Russian Federation
34A, Kashirskoye Shosse, Moscow 115552
A. N. Gromov
Institute of Pharmacoinformatics, Federal Research Center «Informatics and Control», Russian Academy of Sciences
Russian Federation
40, Vavilov St., Moscow 119333
Russian Federation
40, Vavilov St., Moscow 119333
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Review
For citations:
Gromova O.A., Torshin I.Yu., Lila A.M., Gromov A.N. Molecular mechanisms of action of glucosamine sulfate in the treatment of degenerative-dystrophic diseases of the joints and spine: results of proteomic analysis. Neurology, Neuropsychiatry, Psychosomatics. 2018;10(2):38-44. (In Russ.) https://doi.org/10.14412/2074-2711-2018-2-38-44
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