Preview

Neurology, Neuropsychiatry, Psychosomatics

Advanced search

The hemostatic system in neonates whose mothers took antiepileptic agents during pregnancy

https://doi.org/10.14412/2074-2711-2011-146

Full Text:

Abstract

Objective: to study the frequency of thrombohemorrhagic events and the specific features of hemostatic parameters in neonatal infants whose
mother have received antiepileptic agents (AEA) during pregnancy.
Subjects and methods. One hundred and eighty-seven newborn infants were followed up. There was an absolute preponderance of valproic acid
and carbamazepine among the drugs taken by the pregnant women. Hemostatic parameters were examined in the umbilical cord blood of 16 fullterm
neonates. A control group consisted of 11 full-term neonatal infants of non-epileptic mothers who had received no AEA during pregnancy.
The clinical follow-up showed no thrombohemorrhagic events in all 187 cases. A hemostatic study revealed a proportional reduction in the levels
of procoagulants and physiological anticoagulants and an increase in the content of von Willebrand factor in Groups 1 and 2 (a control group).
Overall, the hemostatic parameters in Groups 1 and 2 of the newborns did not significantly differ from those in healthy full-term neonates.

References

1. <div><p>Nulman I., Lasko D., Koren G. Tretment of epilepsy in pregnancy. Drags 1999;57(4):535-44.</p><p>Ried S., Beck-Mannagetta G. Epilepsy, pregnancy and the child. Blackwell Science, 1996;82 p.</p><p>Tomson T. Epilepsy and pregnancy. Wrighton Biomedical Publishing LTD, 1997;215 p.</p><p>Карлов В.А., Власов П.Н., Петрухин В.А. и др. Терапевтическая тактика при эпилепсии во время беременности. Методические указания МЗ РФ N 2001/130;15 с.</p><p>Карлов В.А. Эпилепсия у детей и взрослых женщин и мужчин. Рук-во для врачей. М.: ОАО «Издательство «Медицина», 2010;720 с.</p><p>Minkoff H., Schaffer R.M., Delke I., Grunebaum A.N. Diagnosis of intracranial hemorrafe in utero after a maternal seizure. Obstet Gynecol 1985;65(Suppl. 3):225-43.</p><p>Moslet U., Hansen E.S. A review of vitamin K, epilepsy and pregnancy. Acta Neurol Scand 1992;85:39-43.</p><p>Власов П.Н. Эпилепсия у женщин: клинические, электрофизиологические, гормональные и терапевтические аспекты. Автореф. дис. ... докт. мед. наук. М., 2001;48 с.</p><p>Чупурова А.В. Система неонатального гемостаза в норме и при патологии. Бюлл СО РАМН 2005;4:13-9.</p><p>Astedt B. Antenatal drugs affecting vitamin K status of the fetus and the newborn. Semin Thromb Hemost 1995;21:364-70.</p><p>Шабалов Н.П. Неонатология Т.2. 4-е изд., испр. и доп. М.: МЕДпресс-информ, 2006;656 с.</p><p>Руководство по гематологии. Т.3. Под ред. А.И. Воробьева. 3-е изд., перераб. и доп. М.: Ньюдиамед, 2005;416 с.</p><p>Власов П.Н., Дрожжина Г.Р., Петрухин ВА и др. Особенности системы гемостаза у новорожденных, матери которых страдают эпилепсией. Материалы конгресса с международным участием «Российская эпилептология в современном мире», СПб., 2010;18-9.</p><p>Kaaja E., Kaaja R., Matila R. et al. Enzyme-inducing antiepileptic drugs in pregnancy and the risk of bleeding in the neonate. Neurology 2002;58:549-53.</p><p>Choulika S., Grabowski E., Holmes L.B. Isantenatal vitamin K prophylaxis needed for pregnant women taking anticonvulsants? Am J Obstet Gynecol 2004;190:882-3.</p><p>Harden C.L., Penell P.B., Koppel B.S. et al. Management issues for women with epilepsy - Focus on pregnancy (an evidence-based review): III. Vitamin K, Folic Acid, Blood Levels, and Breast-Feeding: Report of the Quality Standards Subcommittee and Therapeutics and Technology Assessment Subcommittee of American Academy of Neurology and American Epilepsy Society. Epilepsia 2009;50:1247-55.</p></div><br />


For citation:


Petrukhin V.A., Grishin V.L., Mel'nikov A.P., Vlasov P.N., Drozhzhina G.R., Petrukhin V.A., Grishin V.L., Melnikov A.P., Vlasov P.N., Drozhzhina G.R. The hemostatic system in neonates whose mothers took antiepileptic agents during pregnancy. Neurology, Neuropsychiatry, Psychosomatics. 2011;3(2):46-49. (In Russ.) https://doi.org/10.14412/2074-2711-2011-146

Views: 339


Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 License.


ISSN 2074-2711 (Print)
ISSN 2310-1342 (Online)