Antitumor effects of the combined use of vitamins B1, B6, and B12
https://doi.org/10.14412/2074-2711-2017-4-101-105
Abstract
Vitamin B complex is widely used therapeutically and prophylactically in neurology; they are often prescribed for long-term treatment (for weeks and months). In this connection, it is important to comprehensively estimate the feasibility and safety of its use, especially at high (therapeutic) doses. The paper discusses the potential anticancer effects of vitamin B complex.
Objective: to evaluate the effect of thiamine disulfide, pyridoxine hydrochloride, and cyanocobalamin (neurobion 110 mg/kg/day) on the growth and metastatic spread of malignant tumors in mice.
Material and methods. Experiments were carried out in 25 F1 hybrid male mice (aged 2.5–3 months; body weight, 23–26 g). Transplantable Lewis lung epidermoid carcinoma (LLC) was used as a tumor model
Results and discussion. The experimental animals tolerated the drug well; there were no symptoms of intoxication. The drug's effects lasting up to 21 days of LLC development were accompanied by a growing trend towards tumor growth inhibition by 10–20% (p=0.059).
Conclusion. After subchronic intragastric administration of B12 at a daily dose of 110 mg/kg to tumor-bearing animals, there is a steady tendency to LLC growth inhibition. No antimetastatic activity was found.
About the Authors
L. V. Stakhovskaya
Research Institute of Cerebrovascular Disease and Stroke, N.I. Pirogov Russian National Medical Research University, Ministry of Health of Russia
Russian Federation
1, Ostrovityanov St., Moscow 117997
Russian Federation
1, Ostrovityanov St., Moscow 117997
O. A. Gromova
Ivanovo State Medical Academy, Ministry of Health of Russia
Federal Research Center «Informatics and Control», Russian Academy of Sciences
Russian Federation
Russian Federation
8, Sheremetevsky Pr., Ivanovo 153000
40, Vavilov St., Moscow 119333
I. Yu. Torshin
Federal Research Center «Informatics and Control», Russian Academy of Sciences
Russian Federation
40, Vavilov St., Moscow 119333
Russian Federation
40, Vavilov St., Moscow 119333
M. V. Filimonova
National Medical Radiology Research Center, Ministry of Health of Russia
Russian Federation
Russian Federation
4, Korolev St., Obninsk, Kaluga Region 249036
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Review
For citations:
Stakhovskaya LV, Gromova OA, Torshin IY, Filimonova MV. Antitumor effects of the combined use of vitamins B1, B6, and B12. Nevrologiya, neiropsikhiatriya, psikhosomatika = Neurology, Neuropsychiatry, Psychosomatics. 2017;9(4):101-105. (In Russ.) https://doi.org/10.14412/2074-2711-2017-4-101-105
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