Clinical results of and prospects for the use of controlled-release antiepileptic drugs: a new once-daily levetiracetam formulation
https://doi.org/10.14412/2074-2711-2017-3-98-104
Abstract
Many antiepileptic drugs (AEDs) have a short half-life (T1/2) with a wide fluctuation from peak to trough blood concentrations. According to this pharmacokinetic profile, there may be both adverse events (AEs) due to the increase in a blood drug concentrations and seizures as a result of its fall, which ultimately lowers patient adherence to therapy.
Pharmaceutical technologies ensuring a delayed release of the active ingredient can make the concentration of a drug more stable and therefore reduce the frequency and severity of AEs, enhance the efficiency of therapy, compliance, and retention of the patient on AEDs. The emergence of a new sustained-release levetiracetam formulation in neurologists' practice greatly enhances the possibilities of epilepsy therapy.
About the Author
P. N. Vlasov
A.I. Evdokimov Moscow State University of Medicine and Dentistry, Ministry of Health of Russia;
Moscow Regional Research Institute of Obstetrics and Gynecology
Russian Federation
Russian Federation
Department of Nervous System Diseases, Faculty of General Medicine
20, Delegatskaya St., Build. 1, Moscow 127473;
Department of Obstetric Physiology
22a, Pokrovka St., Moscow 101000
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Review
For citations:
Vlasov P.N. Clinical results of and prospects for the use of controlled-release antiepileptic drugs: a new once-daily levetiracetam formulation. Neurology, Neuropsychiatry, Psychosomatics. 2017;9(3):98-104. (In Russ.) https://doi.org/10.14412/2074-2711-2017-3-98-104
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