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Experience with Relatox® in the combination therapy of arm and hand spasticity after stroke

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Objective: to evaluate the safety, efficacy, and tolerability of the botulinum toxin A Relatox® in arm and hand spasticity after ischemic stroke in routine clinical practice.
Patients and methods. The instigation enrolled 7 patients after ischemic stroke (7 years ago) with the signs of upper limb spasticity. All the patients received combination treatment that involved daily kinesiotherapy sessions and electrical stimulation of the paralyzed limbs. Relatox® was once injected into the forearm muscles of the paralyzed arm 6 months or later after stroke. Muscles were chosen according to clinical and electromyographic findings. The patients' status was assessed before, 2 weeks and 3 months after injection.
There were changes in muscle tone, motor abilities of the hand, in the degree of self-service, the presence of subjective sensations, and the degree of local and systemic reactions. The efficiency of therapy was evaluated clinically (Ashworth scale, Frenchay test, Barthel index) and on the basis of an analysis of video monitoring a patient's status and of the consideration of care-givers' views.
Before included in the study, all the patients were treated with different types of botulinum neurotoxin type A made by other manufacturers.
Results. The clinical efficiency of local intramuscular injection of the botulinum toxin type Relatox® in combination with kinesiotherapy and electrical stimulation after 14 days and 3 months after injection was noted in all cases.
The good tolerability, efficacy, and long-term of action of relatox, which were comparable to those of other botulinum neurotoxin type A products, were noted during a 3-month follow-up. Neither side effects no adverse events were identified.
Conclusion. Accumulation of data on the doses and effects of drugs for the local therapy of post-stroke spasticity, which have been obtained by different clinical centers, and the possibility of choosing a medication will be able to improve treatment in such patients.

About the Authors

V. V. Gusev
Central City Clinical Hospital Twenty-Three; First President of Russia B.N. Yeltsin Ural Federal University, Ministry of Education and Science
Russian Federation

9, Starykh Bolshevikov St., Yekaterinburg 620017;
19, Mir St., Yekaterinburg 620002;

O. A. Lvova
First President of Russia B.N. Yeltsin Ural Federal University, Ministry of Education and Science; Ural State Medical University, Ministry of Health of Russia
Russian Federation

19, Mir St., Yekaterinburg 620002;
3, Repin St., Yekaterinburg 620028

T. V. Balueva
Central City Clinical Hospital Twenty-Three
Russian Federation

9, Starykh Bolshevikov St., Yekaterinburg 620017;


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For citations:

Gusev V.V., Lvova O.A., Balueva T.V. Experience with Relatox® in the combination therapy of arm and hand spasticity after stroke. Neurology, Neuropsychiatry, Psychosomatics. 2017;9(3):59-61. (In Russ.)

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ISSN 2074-2711 (Print)
ISSN 2310-1342 (Online)