Neurology, Neuropsychiatry, Psychosomatics

Advanced search

Sleep disorders in Parkinson's disease

Full Text:


Nocturnal sleep disorders are common and clinically significant neuropsychic manifestations of Parkinson's disease (PD).

Objective: to specify the clinical features of sleep disorders in patients with PD and to evaluate the impact of dopaminergic therapy on the basic characteristics of sleep and its related symptoms of the disease.

Subjects and methods. Sixty-seven PD patients without dementia (mean age 63.2±9.9 years; mean PD duration 6.5±4.2 years) were followed up. Forty patients received pramipexole in a daily dose of 2.64±0.6 mg in addition to other dopaminergic agents. The unified PD rating scale (UPDRS), the PD sleep scale (PDSS), the Beck depression inventory and PD fatigue scale (PFS-16), the scales for outcomes of PD-cognition (SCOPA-Cog), and the PD quality of life scale (PDQ-39) were used.

Results. Sleep fragmentation and early morning awakenings are the most common sleep disorders in PD. Pramipexole therapy resulted in a significant improvement in sleep quality, a reduction in the frequency of falling asleep and nocturnal awakenings. The improved characteristics of sleep were favored by a therapy-induced decrease in the severity of motor (hypokinesis, rigidity, tremor, nocturnal and morning dystonia) and nonmotor (restless legs syndrome/acathisia, sensory disorders, nocturia) PD manifestations.

About the Author

M. R. Nodel
I.M. Sechenov First Moscow State Medical University
Russian Federation


1. <div><p>Factor S.A., McAlarney T., Sanchez-Ramos J.R. et al. Sleep disorders and sleep effect in Parkinson's disease. Movement disorders 1990;5:280-5.</p><p>Rascol O., Negre-Pages L., Brefel-Courbon C. et al. Chronic pain and Parkinsons disease. In Non-motor symptoms of Parkinsons disease. K.R. Chaudhuri et al. (eds). New York: Oxford University Press Inc., 2009;287-95.</p><p>Нодель М.Р., Яхно Н.Н. Нервно-психические нарушения болезни Паркинсона. Неврол ней-ропсихиатр психосом 2009;2:3-8.</p><p>Shulman L.M., Taback R.L., Rabinstein A.A. et al. Non-recognition of depression and other non-motor symptoms in Parkinson's disease. Parkinsonism Relat Disord 2002;8(3):193-7.</p><p>Левин Я.И., Ковров Г.В. Нарушения сна и их фармакологическая коррекция у неврологических больных. Психиатр и психофармакотер 2003;5(3):116-9.</p><p>Comella C. Sleep disorders in Parkinsons disease: an overview. Mov Dis 2007;22(Suppl. 17):367-73.</p><p>Karlsen K.H., Larsen J.P., Tanberg E. et al. Influence of clinical and demographic variables on quality of life in patients with Parkinson's disease. J Neurol Neurosurg Psych 1999;66:431-5.</p><p>Larsen J.P. Sleep disorders in Parkinsons disease. Adv Neurol 2003;91:329-4.</p><p>Friedman J.H., Millman R.P. Sleep disturbances and Parkinson's disease. CNS Spectr 2008;13(3):12-7.</p><p>Chaudhuri K.R., Schapira A.H.V. Non-motor symptoms of Parkinsons disease: dopaminergic pathophysiology and treatment. Lancet Neurol 2009;8:464-74.</p><p>Кулуа Т. Ночные симптомы болезни Паркинсона. Болезнь Паркинсона и расстройства движений. Рук-во для врачей по материалам 1 Национального конгресса. М., 22-23 сентября 2008 г.;100-3.</p><p>Нодель М.Р., Яхно Н.Н. Мирапекс (прамипексол) в лечении недвигательных нарушений при болезни Паркинсона. Журн неврол и психиатр им. С.С. Корсакова 2008;(5):32-8.</p><p>Нодель М.Р., Русакова И.М., Яхно Н.Н. Клиническая оценка нарушений сна и бодрствования при болезни Паркинсона. Неврол журн 2010;2:19-25.</p><p>Kumar S., Bhatia M., Behari M. Sleep disorders in Parkinson's disease. Mov Dis 2002;17:775-81.</p><p>Nodel M., Yakhno N. Effects of dopamine agonist pramipexole on sleep disturbances in PD. Abstracts of the XVII WFN World Congress on Parkinson Disease and Related Disorders. 9-13 December 2007, Amsterdam, The Netherlands. 2.232-S.106.</p><p>Chaudhuri K.R., Pal S., DiMarco A. et al. The Parkinson's disease sleep scale: a new instrument for assessing sleep and nocturnal disability in Parkinson's disease. J Neurol Neurosurg Psychiatry 2002;73(6):629-35.</p><p>Brown R.G., Dittner A., Findley L. et al. The Parkinson fatigue scale. Park and Relat Disord 2005;11:49-55.</p><p>Marinus J., Visser M., Verwey N.A. et al. Assessment of cognition in Parkinson's disease. Neurol 2003;61:1222-8.</p><p>Peto V., Jenkinson C., Fitzpatrick R. PDQ-39: A review of the development, validation and application of a Parkinson's disease quality of life questionnaire and its associated measures. J Neurol 1998; 245(Suppl. 1):10-4.</p><p>Нодель М.Р. Утомляемость при болезни Паркинсона. Журн неврол психиатр им. С.С. Корсакова 2009;9:23-6.</p><p>Ядгаров И.С., Аманова З.Н., Каримова А.М. и др. Некоторые аспекты распространенности нарушений сна. Журн неврол и психиатр им. С.С. Корсакова 1994;3:65-7.</p><p>Голубев В.Л., Левин Я.И., Вейн А.М. Болезнь Паркинсона и синдром паркинсонизма. М.: МЕДпресс, 1999;416 с.</p><p>Gillin J.C. Are sleep disturbances risk factors for anxiety, depressive and addictive disorders? Acta Psychiatr Scand Suppl 1998;39(3):39-43.</p><p>Happe S., SchrЪdl B., Faltl M. et al. Sleep disorders and depression in patients with Parkinson's disease. Acta Neurol Scand 2001;104(5):275-80.</p><p>Blackett H., Walker R., Wood B. Urinary dysfunction in Parkinsons disease: a review. Park аnd Relat Dis 2009;15:81-7.</p><p>Poewe W., Rascol O., Quinn N. et al. Efficacy of pramipexole and transdermal rotigotine in advanced Parkinsons disease: a double-blind, double-dummy, randomized controlled trial. Lancet Neurol 2007;6(3):513-20.</p><p>Алексеев А.В., Нодель М.Р., Подчуфарова Е.В. и др. Боли при болезни Паркинсона. Боль 2009;3(24):22-3.</p><p>Aranda B., Cramer P. Effects of apomorphine and l-dopa on the parkinsonian bladder. Neurol Urodyn 1993;12:203-9.</p><p>Barone P. , Poewe W. , Tolosa E. et al. Efficacy of double-blind, placebo-controlled pramipexole against depression in Parkinsons disease. Abstracts of the Movement Disorders Societys Thirteenth International Congress of Parkinson's disease and movement disorders. June 7-11 2009;(Suppl. 1):291.</p></div><br />


For citations:

Nodel M.R. Sleep disorders in Parkinson's disease. Neurology, Neuropsychiatry, Psychosomatics. 2011;3(1):51-56. (In Russ.)

Views: 1954

Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 License.

ISSN 2074-2711 (Print)
ISSN 2310-1342 (Online)