Preview

Neurology, Neuropsychiatry, Psychosomatics

Advanced search

The heterogeneity of patients with epilepsy in terms of psychological characteristics, quality of life, and a response to anticonvulsant therapy

https://doi.org/10.14412/2074-2711-2017-1S-58-63

Full Text:

Abstract

The complex characterization of patients with epilepsy involves a description of their psychological sphere, quality of life, and a response to ongoing anticonvulsant therapy.

Objective: to study the heterogeneity of a group of patients with epilepsy in terms of the indicators of emotional and cognitive disorders, social adaptation, and a response to ongoing anticonvulsant therapy in order to identify criteria for rating these spheres.

Patients and methods. 110 patients with epilepsy were examined. The levels of anxiety and depression, cognitive functions, and quality of life were assessed using the SF-36 and QOLIE-31 questionnaires, as well as the number of seizures and that of taken anticonvulsants were estimated. Multivariate statistical methods were used to divide the patients into subgroups.

Results. Based on the examined characteristics, the investigators identified patient subgroups differing in the level of anxiety and depression, the characteristics of cognitive functions, quality of life, and a response to ongoing therapy with anticonvulsants, established a relationship between these characteristics and the form of epilepsy, and proposed criteria for rating these disorders. The heterogeneity of a group of patients with epilepsy was established using the examined characteristics; the higher level of cognitive impairment, the low efficiency of anticonvulsant therapy and the level of social adaptation were described in patients with symptomatic epilepsy. 

About the Authors

R. A. Zorin
Academician I.P. Pavlov Ryazan Medical State University, Ministry of Health of Russia
Russian Federation
9, Vysokovoltnaya St., Ryazan 390026


V. A. Zhadnov
Academician I.P. Pavlov Ryazan Medical State University, Ministry of Health of Russia
Russian Federation
9, Vysokovoltnaya St., Ryazan 390026


M. M. Lapkin
Academician I.P. Pavlov Ryazan Medical State University, Ministry of Health of Russia
Russian Federation
9, Vysokovoltnaya St., Ryazan 390026


References

1. Berg AT, Berkovic SF, Brodie MJ, et al. Revised terminology and concepts for organization of seizures and epilepsies: report of the ILAE Comission on Classification and Terminologу. 2005–2009. Epilepsia. 2010;51(4):676-85. doi: 10.1111/j.1528-1167.2010.02522.x

2. Kwan P, Arzimanoglou A, Berg AT, et al. Definition of drug resistant epilepsy: consensus proposal by the ad hoc Task Force of the ILAE Comission on Theurapeutic Strategies. Epilepsia. 2010;51(6):1069-77. doi: 10.1111/j.1528-1167.2009.02397.x

3. Меликян ЭГ, Мильчакова ЛЕ, Лебедева АВ и др. Возрастные аспекты исследования качества жизни больных эпилепсией. Журнал неврологии и психиатрии им. С.С. Корсакова 2012;112(6-2):78-82 [Melikian EG, Mil'chakova LE, Lebedeva AV, et al. Age aspects of quality of life research in patients with epilepsy. Zhurnal Nevrologii i Psikhiatrii im. S.S. Korsakova = SS Korsakov Journal of Neurology and Psychiatry. 2012;112(6-2):78-82 (In Russ.)].

4. Михайлов ВА. Актуальные вопросы эпилептологии – стигматизация, качество жизни и реабилитация больных. Эпилепсия и пароксизмальные состояния. 2010;2(3):39-44 [Mikhailov VA. Topical issues of epileptology – stigmatization, quality of life and rehabilitation of patients. Epilepsiya i Paroksizmal'nye Sostoyaniya. 2010;2(3):39-44 (In Russ.)].

5. Калинин ВА, Якунина АВ, Повереннова ИЕ. Закономерности течения эпилепсии в разные возрастные периоды. Неврология, нейропсихиатрия, психосоматика. 2015;7(1S):26-30 [Kalinin VA, Yakunina AV, Poverennova IE. Regularities in the course of epilepsy during various age periods. Nevrologiya, Neiropsikhiatriya, Psikhosomatika = Neurology, Neuropsychiatry, Psychosomatics. 2015;7(1S):26-30 (In Russ.)]. doi: 10.14412/2074-2711-2015-1S-26-30.

6. Мантрова НН. Методическое руководство по психофизиологической и психологической диагностике. Иваново: Нейрософт; 2007 [Mantrova NN. Metodicheskoe rukovodstvo po psikhofiziologicheskoi i psikhologicheskoi diagnostike [Methodological guidelines for psychophysiological and psychological diagnosis]. Ivanovo: Neirosoft; 2007].

7. Новиков АЕ. Эволюция в клинической эпилептологии. Иваново: Издательство ИвГМА; 2006 [Novikov AE. Evolyutsiya v klinicheskoi epileptologii [Evolution in clinical epileptology]. Ivanovo: IvSMA Publishing House; 2006].

8. Dubois B, Slachevsky A, Litvan I, et al. The FAB: A Frontal Assesment Battery at bedside. Neurology. 2000;55(11):1621-6. doi: 10.1212/WNL.55.11.1621

9. Nasreddine ZS, Phillips NA, Bedirian V, et al. The Monreal Cognitive Assesment, MoCA: a brief screening tool for mild cognitive impairment. J Amer Geriatr Soc. 2005;53(4): 695-9. doi: 10.1111/j.1532-5415.2005.53221.x

10. Новик АА, Ионова ТИ. Руководство по исследованию качества жизни в медицине. Москва: ОЛМА-ПРЕСС; 2002 [Novik AA, Ionova TI. Rukovodstvo po issledovaniyu kachestva zhizni v meditsine [Guide to the study of quality of life in medicine]. Moscow: OLMA-PRESS; 2002].

11. Cramer JA, Perrine K, Devinsky O, et al. Development and cross-cultural translations of a 31-item quality of life in epilepsy inventory. Epilepsia. 1998;39(1):81-8. doi: 10.1111/j.1528-1157.1998.tb01278.x

12. Ware JE, Snow KK, Kosinski M, Gandek B. Sf-36 Healh Survey. Manual and Interpretation Guide. Lincoln, RI: QualityMetric Incorporated; 2000.

13. Боев ВМ, Борщук ЕЛ, Екимов АК и др. Руководство по обеспечению решения медико-биологических задач с применением программы Statistica 10.0. Оренбург: Южный Урал; 2014 [Boev VM, Borshchuk EL, Ekimov AK, et al. Rukovodstvo po obespecheniyu resheniya mediko-biologicheskikh zadach s primeneniem programmy Statistica 10.0 [Guide to the solution of biomedical problems with the application of Statistica 10.0]. Orenburg: Yuzhnyi Ural; 2014].

14. Дубров АМ, Мхитарян ВС, Трошин ЛИ. Многомерные статистичекие методы. Москва: Финансы и статистика; 2000 [Dubrov AM, Mkhitaryan VS, Troshin LI. Mnogomernye statistichekie metody [Multivariate statistical methods]. Moscow: Finansy i statistika; 2000].

15. Fisher RS, Acevedo C, Arzimanoglou A, et al. ILAE official report: a practical clinical definition of epilepsy. Epilepsia. 2014;55(4): 475-82. doi: 10.1111/epi.12550

16. Котов АС. Тревога у страдающих эпилепсией пациентов. Журнал неврологии и психиатрии им. С.С. Корсакова. 2013;113(4-2):41-4 [Kotov AS. Anxiety in epileptic patients. Zhurnal Nevrologii i Psikhiatrii im. S.S. Korsakova = SS Korsakov Journal of Neurology and Psychiatry. 2013;113(4-2):41-4 (In Russ.)].

17. Kanner AM, Barry JJ, Gilliam F, et al. Depressive and anxiety disorders in epilepsy: Do they differ in their potential to worsen common antiepileleptic drug-related adverse events? Epilepsia. 2012;53(6):1104-8. doi: 10.1111/j.1528-1167.2012.03488.x

18. Moshe SL, Perucca E, Ryvlin P, et al. Epilepsy: new advances. Lancet. 2015; 385(9971):884-98. doi: 10.1016/S0140-6736(14)60456-6

19. Bonini F, McGonigal A, Trebuchon A, et al. Frontal lobe seizures: from clinical semiology to localization. Epilepsia. 2014;55(2):264-77. doi: 10.1111/epi.12490

20. Карлов ВА. Эпилепсия у детей и взрослых женщин и мужчин. Москва: Медицина; 2010 [Karlov VA. Epilepsiya u detei i vzroslykh zhenshchin i muzhchin [Epilepsy in children and adult women and men]. Moscow: Meditsina; 2010].


For citation:


Zorin R.A., Zhadnov V.A., Lapkin M.M. The heterogeneity of patients with epilepsy in terms of psychological characteristics, quality of life, and a response to anticonvulsant therapy. Neurology, Neuropsychiatry, Psychosomatics. 2017;9(1S):58-63. (In Russ.) https://doi.org/10.14412/2074-2711-2017-1S-58-63

Views: 161


Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 License.


ISSN 2074-2711 (Print)
ISSN 2310-1342 (Online)