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Analysis of hormone-dependent pathology in female patients with juvenile myoclonic epilepsy

https://doi.org/10.14412/2074-2711-2017-1S-32-38

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Abstract

Objective: to study the characteristics of manifestations of hormonal abnormalities in women with juvenile myoclonic epilepsy (JME) and to comparatively analyze identified syndromes.

Patients and methods. Hormonal disorders were analyzed in 48 reproductive-aged women with JME, who had received antiepileptic drug (AED) mono- and bitherapy during one or more years.

Results. 66.7% of the patients were found to have ovarian hormonal dysfunction manifesting itself as the development of polycystic ovary syndrome, hypogonadism, isolated hyperandrogenism, and hypoprogesteronemia. Clinically detected syndromes frequently appeared as menstrual irregularity in 29% of the patients. Comparative analysis of hormone-dependent syndromes showed that there were no differences in the clinical features of JME, but the earliest age at onset in isolated hyperandrogenism, and no patients with menstrual irregularity in the presence of isolated hypoprogesteronemia. The use of different AEDs had no impact on the incidence of hormonal abnormalities, which requires further investigation and its inclusion of a greater number of patients receiving various AEDs. 

About the Authors

D. V. Anisimova
Bashkir State Medical University, Ministry of Health of Russia
Russian Federation

Department of Neurology with Course of Neurosurgery and Medical Genetics, 

3, Lenin St., Ufa 450008



R. V. Magzhanov
Bashkir State Medical University, Ministry of Health of Russia
Russian Federation

Department of Neurology with Course of Neurosurgery and Medical Genetics, 

3, Lenin St., Ufa 450008



P. N. Vlasov
A.I. Evdokimov Moscow State University of Medicine and Dentistry, Ministry of Health of Russia
Russian Federation

Department of Nervous System Diseases, Faculty of General Medicine, 

20, Delegatskaya St., Build. 1, Moscow 127473



V. A. Petrukhin
Moscow Regional Research Institute of Obstetrics and Gynecology
Russian Federation
22a, Pokrovka St., Moscow 101000


E. B. Tsevtsivadze
Moscow Regional Research Institute of Obstetrics and Gynecology
Russian Federation
22a, Pokrovka St., Moscow 101000


S. R. Nurmukhametova
Bashkir State Medical University, Ministry of Health of Russia
Russian Federation

Department of Neurology with Course of Neurosurgery and Medical Genetics, 

3, Lenin St., Ufa 450008



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For citation:


Anisimova D.V., Magzhanov R.V., Vlasov P.N., Petrukhin V.A., Tsevtsivadze E.B., Nurmukhametova S.R. Analysis of hormone-dependent pathology in female patients with juvenile myoclonic epilepsy. Neurology, Neuropsychiatry, Psychosomatics. 2017;9(1S):32-38. (In Russ.) https://doi.org/10.14412/2074-2711-2017-1S-32-38

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