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MexiB 6 AS A RESULT OF FORTIFICATION OF ETHYLMETHYLHYDROXYPYRIDINE SUCCINATE WITH MAGNESIUM AND PYRIDOXINE: PROTEOME EFFECTS

https://doi.org/10.14412/2074-2711-2016-4-38-44

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Abstract

The efficacy of ethylmethylhydroxypyridine succinate (EMHPS)  depends on the concentration and activity of proteomic proteins. To provide the body with magnesium and pyridoxine is an important condition for the efficacy of EMHPS because these micronutrients are essential for maintaining neuronal function.

Objective: to analyze the biological effects of pyridoxineand magnesium-dependent proteins providing the molecular mechanisms of multi-targeted action of EMHPS,  pyridoxine, and magnesium.

Material and methods. Proteins that interact with both pyridoxine and magnesium were found in the genomic and proteomic databases. A list of 78 vitamin B6-dependent proteins, which is based on the available human genome records in NCBIPROTEIN, EMBL,  UNIPROT,  and HumanProteomeMap databases, was analyzed using a functional binding assay. The same assay was also applied to analyze a list 720 magnesium-dependent proteins.

Results. The analysis has shown that 78 pyridoxine-dependent proteomic proteins are necessary for: 1) the synthesis and processing of amino acids; 2) cell energy metabolism (ATP synthesis), and 3) the synthesis of neurotransmitters and neuronal membranes. MexiB 6 has numerous synergistic interactions between the molecules of EMHPS,  pyridoxine, and magnesium. The combination of the components of EMHPS,  pyridoxine and magnesium in MexiB 6 (triple synergism) allows prediction that the drug has more pronounced clinical effects than the molecules of EMHPS,  which emerges in its antihypoxic and antioxidant activities, the improvement of synaptic transmission of a signal, the neutralization of homocysteine, and the regulation of lipid and carbohydrate metabolism (restoration of cell sensitivity to insulin and carbohydrates in patients with atherosclerosis and in those at risk for diabetes mellitus or obesity). Pyridoxineand magnesium-induced potentiation of the effects of EMHPS may enhance its activity.

About the Authors

O. A. Gromova
Ivanovo State Medical Academy
Russian Federation

Olga Alekseevna Gromovaю.

8, Sheremetevsky Pr., Ivanovo 153000, unesco.gromova@gmail.com



I. Yu. Torshin
Moscow Institute of Physics and Technology
Russian Federation

9, Institutsky Lane, Dolgoprudnyi, Moscow Region 141700



A. G. Kalacheva
Ivanovo State Medical Academy
Russian Federation

8, Sheremetevsky Pr., Ivanovo 153000



V. A. Semenov
Kemerovo State Medical Academy
Russian Federation

22A, Voroshilov St., Kemerovo 650056



K. V. Rudakov
Moscow Institute of Physics and Technology
Russian Federation

9, Institutsky Lane, Dolgoprudnyi, Moscow Region 141700



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For citation:


Gromova O.A., Torshin I.Y., Kalacheva A.G., Semenov V.A., Rudakov K.V. MexiB 6 AS A RESULT OF FORTIFICATION OF ETHYLMETHYLHYDROXYPYRIDINE SUCCINATE WITH MAGNESIUM AND PYRIDOXINE: PROTEOME EFFECTS. Neurology, Neuropsychiatry, Psychosomatics. 2016;8(4):38-44. (In Russ.) https://doi.org/10.14412/2074-2711-2016-4-38-44

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