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Molecular mechanisms responsible for the impact of antiepileptic therapy on bone mineral density of epileptic patients

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Antiepileptic drugs (AEDs) may have a negative effect on bone tissue, by increasing the risk of fractures in epileptic patients compared to the general population. Many investigations have shown lower bone mineral density and a higher risk for osteopenia and osteoporosis in patients taking traditional and novel AEDs. Multidrug therapy and the duration of AED intake are associated with the most significant risk for lower bone mineral density. Nevertheless, the molecular mechanisms of action of different AEDs on bone tissue remain little studied.

About the Authors

I. A. Zhidkova
A.I. Evdokimov Moscow State University of Medicine and Dentistry, Ministry of Health of Russia
Russian Federation
Department of Nervous System Diseases, Faculty of General Medicine

T. V. Kaznacheeva
A.I. Evdokimov Moscow State University of Medicine and Dentistry, Ministry of Health of Russia
Russian Federation
Department of Reproductive Medicine and Surgery, Faculty of Additional

E. Yu. Demidova
A.I. Evdokimov Moscow State University of Medicine and Dentistry, Ministry of Health of Russia
Russian Federation
Department of Nervous System Diseases, Faculty of General Medicine

V. V. Berseneva
A.I. Evdokimov Moscow State University of Medicine and Dentistry, Ministry of Health of Russia
Russian Federation
Department of Reproductive Medicine and Surgery, Faculty of Additional


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For citation:

Zhidkova I.A., Kaznacheeva T.V., Demidova E.Yu., Berseneva V.V. Molecular mechanisms responsible for the impact of antiepileptic therapy on bone mineral density of epileptic patients. Neurology, Neuropsychiatry, Psychosomatics. 2016;(1S):59-65. (In Russ.)

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