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The role of frontal-subcortical circuits in the development of obsessive-compulsive disorders

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The paper presents a concise review of investigations into the role of impaired frontal-subcortical circuits in the development of obsessive-compulsive disorder (OCD). It gives data on the frequency of neurosis-like symptoms of the OCD spectrum in neurological diseases.

The development of OCD is associated with an imbalance between the activity of the direct (activating) and indirect (inhibitory) pathways of the cortico-striatal-thalamo-cortical feedback loop. These data are confirmed by the results of neuroimaging and neuropsychological studies in patients with OCD. The frequency of OCD symptoms is high in organic brain lesions. OCP may be a manifestation of neurological diseases so their timely detection is an important aspect of a neurologist's work. The treatment of patients with neurosis-like disorders of the OCD spectrum within neurological diseases requires a multidisciplinary approach with the participation of a neurologist, a psychiatrist/psychotherapist, and a psychologist. It is necessary to combine pathogenetic treatment of the underlying disease and its neurosis-like manifestations. 

About the Author

M. A. Kutlubaev
G.G. Kuvatov Republican Clinical Hospital, Ufa; Bashkir State Medical University, Ministry of Health of Russia, Ufa
Russian Federation

Department of Neurology

Department of Neurology with Courses of Neurosurgery and Medical Genetics

132, Dostoevsky St., Ufa 450005, Bashkortostan

3, Lenin St., Ufa 450000, Bashkortostan 


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For citations:

Kutlubaev M.A. The role of frontal-subcortical circuits in the development of obsessive-compulsive disorders. Neurology, Neuropsychiatry, Psychosomatics. 2016;8(2):107-112. (In Russ.)

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