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Effects of etifoxine: Chemoreactome simulation

https://doi.org/10.14412/2074-2711-2016-2-44-49

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Abstract

Etifoxine modulates GABAergic transmission and is used as an anxiolytic (anti-anxiety) medication. The indications for etifoxine use are anxiety, fear and inner tension.

Objective: to simulate the biological properties of etifoxine. This simulation has been carried out for the first time.

Material and methods. Reliable estimates of more than 2,500 biological activities were obtained for this molecule, which were compared with the reference drug lorazepam (benzodiazepine).

Results and discussion. The data obtained from chemoreactome simulation may suggest that there are significant differences between the pharmacological effects of etifoxine and benzodiazepine in: 1) the selectivity of binding to various neurotransmitter receptors; 2) anti-inflammatory activity; 3) the effect on hemodynamics and vascular walls; 4) negative side effects and 5) pharmacokinetic parameters.

Conclusion. The findings are consistent with the available experimental and clinical data and are indicative of promising clinical applications of etifoxine. 

About the Authors

I. Yu. Torshin
Moscow Institute of Physics and Technology, Dolgoprudnyi
Russian Federation

9, Institutskiy Lane, Dolgoprudnyi, Moscow Region 141700



O. A. Gromova
Ivanovo State Medical Academy, Ministry of Health of Russia, Ivanovo
Russian Federation

8, Sheremetevsky Passage., Ivanovo 153000



L. E. Fedotova
Ivanovo State Medical Academy, Ministry of Health of Russia, Ivanovo
Russian Federation

8, Sheremetevsky Passage., Ivanovo 153000



A. N. Gromov
Federal Research Center «Information Science and Management», Russian Academy of Sciences», Moscow
Russian Federation

44/2, Vavilov St., Moscow 119333 



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For citation:


Torshin I.Yu., Gromova O.A., Fedotova L.E., Gromov A.N. Effects of etifoxine: Chemoreactome simulation. Neurology, Neuropsychiatry, Psychosomatics. 2016;8(2):44-49. (In Russ.) https://doi.org/10.14412/2074-2711-2016-2-44-49

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ISSN 2074-2711 (Print)
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