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Role of lipoprotein (a) in the development of ischemic stroke and other cardiovascular diseases

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The paper gives the data available in the literature on the role of a level of elevated lipoprotein (a) (Lp (a)) in the development of ischemic stroke and other cardiovascular diseases. It shows the normal level of Lp (a) and the typical distribution of its concentration for people of European origin and representatives of other races. There is evidence on the genetic determination and variability of the Apo (a) gene. The paper presents the results of the recent large survey of 8000 patients with coronary heart disease and 8000 control persons, which has studied candidate genes for cardiovascular diseases. It indicates the role of Lp (a) as a risk factor for early atherosclerosis and describes main pathomorphological mechanisms. The propositions that it is necessary to screen Lp (a) in different risk groups, its target level, and possible methods for correcting the elevated Lp (a) level are given.

About the Authors

N. A. Pizov
Yaroslavl State Medical University, Ministry of Health of Russia, Yaroslavl, Russia 5, Revolyutsionnaya St., Yaroslavl 150000
Russian Federation
Department of Neurology and Medical Genetics with Course of Neurosurgery

N. V. Pizova
Yaroslavl State Medical University, Ministry of Health of Russia, Yaroslavl, Russia 5, Revolyutsionnaya St., Yaroslavl 150000
Russian Federation
Department of Neurology and Medical Genetics with Course of Neurosurgery


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For citation:

Pizov N.A., Pizova N.V. Role of lipoprotein (a) in the development of ischemic stroke and other cardiovascular diseases. Neurology, Neuropsychiatry, Psychosomatics. 2016;8(1):90-95. (In Russ.)

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