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A clinical case of a patient with probable cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) from Chuvashia

https://doi.org/10.14412/2074-2711-2015-3-57-61

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Abstract

Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) syndrome is a congenital small-vessel disease running with recurrent lacunar infarcts and leading to gradually progressive subcortical, pseudobulbar, and cerebellar syndromes and dementia. Neuroimaging reveal multiple lacunar infarcts in the basal ganglia, thalamus, pons Varolii, and cerebral hemispheric white matter, as well as cerebral atrophy. The specific feature of the disease is white matter lesion adjacent to the temporal horns of the lateral ventricles and to the external capsules. The paper describes a patient with CADASIL syndrome. The latter runs a progressive course and includes the following neurological disorders: cognitive, pyramidal, extrapyramidal, and axial ones. This clinical case was differentially diagnosed with multiple sclerosis, including with consideration for neuroimaging findings. The CADASIL syndrome is a rare potentially menacing neurological condition that is observed in young patients and requires a detailed examination using current diagnostic techniques.

About the Authors

Tatiana Vladimirovna Mokina
Emergency Care Hospital; I.N. Ulyanov Chuvash State University, Ministry of Health of Russia
Russian Federation

47, Moskovsky Prospekt, Cheboksary 428015 Chuvashia;

Department of Psychiatry, Medical Psychology, and Neurology, 15, Moskovsky Prospekt, Cheboksary 428015 



A. V. Zvereva
Emergency Care Hospital
Russian Federation

47, Moskovsky Prospekt, Cheboksary 428015 Chuvashia;

Department of Psychiatry, Medical Psychology, and Neurology, 15, Moskovsky Prospekt, Cheboksary 428015 

 



Yu. I. Pavlov
Republical Clinical Hospital
Russian Federation
9, Moskovsky Prospekt, Cheboksary 428015


N. K. Sumkin
Emergency Care Hospital
Russian Federation
47, Moskovsky Prospekt, Cheboksary 428015 Chuvashia


T. V. Karpova
Emergency Care Hospital
Russian Federation
47, Moskovsky Prospekt, Cheboksary 428015 Chuvashia


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For citation:


Mokina T.V., Zvereva A.V., Pavlov Y.I., Sumkin N.K., Karpova T.V. A clinical case of a patient with probable cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) from Chuvashia. Neurology, Neuropsychiatry, Psychosomatics. 2015;7(3):57-61. (In Russ.) https://doi.org/10.14412/2074-2711-2015-3-57-61

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ISSN 2074-2711 (Print)
ISSN 2310-1342 (Online)