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Efficiency of epilepsy treatment in the Moscow Region under the present-day conditions of drug provision

https://doi.org/10.14412/2074-2711-2015-3-10-14

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Abstract

Objective: to evaluate the efficiency of epilepsy therapy in the two periods 2006–2007 and 2013–2014 due to drug provision-related changes: the use of antiepileptic drugs (AEDs) in accordance with their international nonproprietary name.

Patients and methods. The continuous sample survey enrolled patients aged 18 years and older, who had been seen by an epileptologist at the Moscow Regional Research Clinical Institute in 2006–2007 (n=1200) and 2013–2014 (n=1450). The patients who had received initial therapy (n=384) were divided into 2 groups in accordance with the type of drug provision. Group 1 (n=124) had recommended AEDs. In Group 2 (n=260), there was switching between AED analogues in 80% of the patients. Therapeutic efficiency was comparatively analyzed in relation to the AEDs used and treatment policies.

Results. In 2013–2014 versus 2006–2007, the rate of remissions and the number of respondents was halved. The analysis demonstrated significant differences (p<0.05) between Groups 1 and 2 in the following indicators: the number of respondents (75:52%), remission rates (58:38%), pharmacoresistance (25:47%), the frequency of use of brand (54:34%) and generic (45:65%) AEDs, and that of switching between AED analogues (0:80%).

About the Authors

Irina Gennadyevna Rudakova
M.F. Vladimirsky Moscow Regional Research Clinical Institute
Russian Federation
61/2, Shchepkin St., Moscow 129110


Yu. A. Belova
M.F. Vladimirsky Moscow Regional Research Clinical Institute
Russian Federation
61/2, Shchepkin St., Moscow 129110


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For citation:


Rudakova I.G., Belova Y.A. Efficiency of epilepsy treatment in the Moscow Region under the present-day conditions of drug provision. Neurology, Neuropsychiatry, Psychosomatics. 2015;7(3):10-14. (In Russ.) https://doi.org/10.14412/2074-2711-2015-3-10-14

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ISSN 2074-2711 (Print)
ISSN 2310-1342 (Online)