Preview

Neurology, Neuropsychiatry, Psychosomatics

Advanced search

Cervicogenic headache: the specific features of complex therapy with Amelotex and CompligamV

https://doi.org/10.14412/2074-2711-2010-86

Full Text:

Abstract

An open-labeled study of the efficiency and tolerance of complex injection therapy with Amelotex in a dose of 15 mg/day for 6 days and CompligamV in a dose of one ampoule for 15 days was conduced in 30 patients (24 women and 6 men) aged 45 to 71 years with chronic cervicogenic headache (CGH) (its duration of 2 months to 10 years). The Numerical Rating Scale (NRS), the Visual Analog Scale (VAS), the McGill Pain Questionnaire (MPQ), and the Brief Pain Inventory (BPI) developed by C.S. Cleeland were used to rate different characteristics of pain and to evaluate the efficiency of treatment. Laboratory redetermination of the levels of von Willebrand factor, factor VIII, antithrombin III, D-dimer, and homocysteine was made in 10 patients to study hemostatic parameters. Combined injection therapy with Amelotex and CompligamV in patients with CGH reduced the intensity of acute and chronic pain, by affecting both the sensory-discriminative and affective-motivational pain components. The therapy did not worsen endothelial dysfunction, a marker of activated blood coagulation; there was a rise in the content of antithrombin III (within the normal range). Combined injection therapy with Amelotex and CompligamV was observed to be well tolerated and to cause no adverse reactions.

About the Author

Mariya Lvovna Pospelova



References

1. <div><p>Болезни нервной системы. Руководство для врачей. Под ред. акад. РАМН Н.Н. Яхно. М.: Медицина, 2007.</p><p>Боль. Руководство для врачей. Под ред. акад. РАМН Н.Н. Яхно. М.: МЕДпресс-информ, 2009.</p><p>Кукушкин М.Л., Хитров Н.К. Общая патология боли. М.: Медицина, 2004.</p><p>Насонов Е.Л., Цветкова Е.С., Тов Н.Л. Селективные ингибиторы циклооксигеназы-2. Новые перспективы лечения заболеваний человека. Тер. арх. 1998; (5): 8-14.</p><p>Насонов Е.Л. Специфические ингибиторы циклооксигеназы-2, решенные и не решенные проблемы. Клин. фармакол. и тер. 2000; 1: 57-64.</p><p>Hawkey C.J. COX-2 inhibitors. Lancet 1999; 353: 307-14.</p><p>Silverstein F.E., Faich G., Goldstein J.L. et al. Gastrointestinal toxicity with celecoxib versus nonsteroidal anti-inflammatory drugs for osteoarthritis and rheumatoid arthritis: the CLASS study: arandomized controlled trial. Celecoxid long-term arthritis saferty study. JAMA 2000; 284: 1247-55.</p><p>Mukherjee D., Nissen S.E., Topol E.J. Risk of cardiovascular events associated with selective COX. 2 inhibitors. JAMA 2001; 286: 954-9.</p></div><br />


For citation:


Pospelova M.L. Cervicogenic headache: the specific features of complex therapy with Amelotex and CompligamV. Neurology, Neuropsychiatry, Psychosomatics. 2010;2(2):58-62. (In Russ.) https://doi.org/10.14412/2074-2711-2010-86

Views: 366


Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 License.


ISSN 2074-2711 (Print)
ISSN 2310-1342 (Online)