Preview

Neurology, Neuropsychiatry, Psychosomatics

Advanced search

Intravenous Antiepileptic Drugs in Russia

https://doi.org/10.14412/2074-2711-2014-1S-48-53

Full Text:

Abstract

Launching four intravenous antiepileptic drugs: valproate (Depakene and Convulex), lacosamide (Vimpat), and levetiracetam (Keppra) – into the Russian market has significantly broadened the possibilities of rendering care to patients in seizure emergency situations. The chemi- cal structure, mechanisms of action, indications/contraindications, clinical effectiveness and tolerability, advantages/disadvantages, and adverse events of using these drugs in urgent and elective neurology are discussed. 

About the Author

P. N. Vlasov
A.I. Evdokimov Moscow State University of Medicine and Dentistry, Ministry of Healthcare of the Russian Federation, Moscow
Russian Federation
Division of Diseases of the Nervous System, Department of General Medicine


References

1. Карлов ВА. Эпилептический статус. Эпи- лепсия у детей и взрослых женщин и муж- чин. Москва: Медицина; 2010. С. 483–511. [Karlov VA. Epilepticheskii status. Epilepsiya u detei i vzroslykh zhenshchin i muzhchin. Moscow: Meditsina; 2010. P. 483–511.]

2. Rossetti AO, Lowenstein DH. Management of refractory status epilepticus in adults: still more questions than answers. Lancet Neurol. 2011;10(10):922–30. DOI: 10.1016/S1474- 4422(11)70187-9.

3. Лебедева АМ, Карлов ВА, Сидоров АМ и др. Опыт применения инъекционной фор- мы вальпроевой кислоты (конвулекс) у больных с серийными эпилептическими приступами и эпилептическим статусом на догоспитальном этапе. Спецвыпуск «Эпи- лепсия». Неврология, нейропсихиатрия, психосоматика. 2012;(1S)53–9. [Lebedeva AV, Karlov VA, Sidorov AM, et al. Experience in using injectable valproic acid (convulex) in patients with serial epileptic seizures and status epilepticus at the prehospital stage. Special issue "Epilepsy". Neurology, Neuropsychiatry, Psychosomatics. 2012;(1S)53–9.]. DOI: http://dx.doi.org/10.14412/2074-2711-2012- 2500

4. Карлов ВА, Андреева ОВ. Современные представления об эпилептическом статусе и возможности терапии с использованием инъ- екционной формы вальпроата (конвулекса). Журнал неврологии и психиатрии им. С.С. Корсакова. 2010;110(11):7–12. [Karlov VA, Andreeva OV. Modern conceptions on the sta- tus epilepticus and possibilities of treatment with injection form of valproate (convulex). Zhurnal nevrologii i psikhiatrii im. S.S. Korsakova. 2010;110(11):7–12.]

5. Холин АА, Ильина ЕС, Лемешко ИД и др. Злокачественные мигрирующие парци- альные приступы младенчества. Опыт при- менения инъекционной формы конвулекса при младенческом эпилептическом статусе (наблюдение из практики). Журнал невро- логии и психиатрии им. С.С. Корсакова. 2010;110(2 приложение 3):17–24. [Kholin AA, Il'ina ES, Lemeshko ID, et al. Zlokachestvennye migriruyushchie partsial'nye pristupy mladenchestva. Opyt primeneniya in"ektsionnoi formy konvuleksa pri mladench- eskom epilepticheskom statuse (nablyudenie iz praktiki). Zhurnal nevrologii i psikhiatrii im. S.S. Korsakova. 2010;110(2 Suppl 3):17–24.]

6. Холин АА, Воронкова КВ, Пылаева ОА, Петрухин АС. Эффективность и безопас- ность внутривенного применения вальпроа- тов. Журнал неврологии и психиатрии им. С.С. Корсакова. 2010;110(2 приложение 3):55–9. [Kholin AA, Voronkova KV, Pylaeva OA, Petrukhin AS. Effektivnost' i bezopasnost' vnu- trivennogo primeneniya val'proatov. Zhurnal nevrologii i psikhiatrii im. S.S. Korsakova. 2010;110(2 prilozhenie 3):55–9.]

7. Krauss G, Ben-Menachem E, Mameniskiene R, et al. Intravenous lacosamide as short-term replacement for oral lacosamide in partial-onset seizures. Epilepsia. 2010;51(6):951–7. DOI: 10.1111/j.1528- 1167.2009.02463.x. Epub 2009 Dec 22.

8. Hofler J, Unterberger I, Dobesberger J, et al. Intravenous lacosamide in status epilepticus and seizure clusters. Epilepsia.

9. ;52(10):e148–e152. DOI: http://dx.doi.org/10.1111/j.1528- 1167.2011.03204.x.

10. Kellinghaus C, Berning S, Besselmann M. Intravenous lacosamide as successful treatment for nonconvulsive status epilepticus after failure of first-line therapy. Epilepsy Behav. 2009;14(2):429–31. DOI: 10.1016/j.yebeh.2008.12.009. Epub 2009 Jan 6. 10. Koubeissi MZ, Mayor CL, Estephan B, et al. Efficacy and safety of intravenous lacosamide in refractory nonconvulsive status epilepticus. Acta Neurol Scand. 2011;123(2):142–6. DOI: 10.1111/j.1600- 0404.2010.01430.x. Epub 2010 Oct 10.

11. Власов ПН, Камелькова ЕГ, Дрожжина ГР. Эффективность и переноси- мость лакосамида для внутривенного введе- ния при ургентных неврологических ситуа- циях. Cпецвыпуск Эпилепсия. Неврология, нейропсихиатрия, психосоматика. 2012;(1S):60–3. [Vlasov PN, Kamelkova EG, Drozzhina GR. Efficacy and tolerance of intra- venous lacosamide in urgent neurological situa- tions. Special issue Epilepsy. Neurology, Neuropsychiatry, Psychosomatics. 2012;(1S):60–3.]. DOI: http://dx.doi.org/10.14412/2074-2711-2012- 2501.

12. Fountain NB, Krauss G, Isojarvi J, et al. Safety and tolerability of adjunctive lacosamide intravenous loading dose in lacosamide-naive patients with partial-onset seizures. Epilepsia. 2013;54(1):58–65. DOI: http://dx.doi.org/10.1111/j.1528- 1167.2012.03543.x

13. .

14. Tilz C, Resch R, Hofer T, Eggers C. Successful treatment for refractory convulsive status epilepticus by non-parenteral lacosamide. Epilepsia. 2010;51(2):316–7. DOI: http://dx.doi.org/10.1111/j.1528- 1167.2009.02256.x.

15. Hö fler J, Trinka E. Lacosamide as a new treatment option in status epilepticus. Critical Review and Invited Commentary. Epilepsia. 2013;54(3):393–404. DOI: http://dx.doi.org/10.1111/epi.12058.

16. Ramael S, De Smedt F, Toublanc N, et al. Single-dose bioavailability of levetiracetam intravenous infusion relative to oral tablets and multiple-dose pharmacokinetics and tolerability of levetiracetam intravenous infusion compared with placebo in healthy subjects. Clinical Therapeutics. 2006;28(5):734–44. DOI: http://dx.doi.org/10.1016/j.clinthera.2006.05.0 04.

17. Ramael S, Daoust A, Otoul C, et al. Levetiracetam intravenous infusion: a random- ized, placebo-controlled safety and pharmaco- kinetic study. Epilepsia. 2006;47(7):1128–35. DOI: http://dx.doi.org/10.1111/j.1528- 1167.2006.00586.x.

18. Aiguabella М, Falip М, Villanueva М, et al. Efficacy of intravenous levetiracetam as an add- on treatment in status epilepticus: а multicen- tric observational study. Seizure. 2011;20(1):60–4. DOI: 10.1016/j.seizure.2010.10.009. Epub 2010 Dec 10.

19. Alvarez М, Januel J-M, Burnand В, Rossetti AO. Second-line status epilepticus treatment: Comparison of phenytoin, valproate, and levetiracetam. Epilepsia. 2011;52(7):1292–6. DOI: http://dx.doi.org/10.1111/j.1528- 1167.2011.03056.x.

20. Yasiry ZSY. The outcome of antiepileptic drug therapy in benzodiazepine-resistant status epilepticus: a review of published cases and tri- als. Epilepsia. 2012;53(Suppl 5):30(p098).


For citation:


Vlasov P.N. Intravenous Antiepileptic Drugs in Russia. Neurology, Neuropsychiatry, Psychosomatics. 2014;6(1S):48-53. (In Russ.) https://doi.org/10.14412/2074-2711-2014-1S-48-53

Views: 426


Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 License.


ISSN 2074-2711 (Print)
ISSN 2310-1342 (Online)