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Clinical electroencephalographic criteria for the efficacy of rispolept therapy in children with Tourette's syndrome

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To develop the clinical and electroencephalographic criteria for the efficiency of rispolept in children with Tourette's syndrome, the authors analyze the results of treatment in 15 patients aged 8-15 years who took rispolept in a dose of 2-3 mg/day. The clinical and electroencephalographic assessment of the therapy for tick hyperkinesis revealed a significant reduction in the frequency of ticks, a decrease in the number of hyperkinesis tests, and normalization of bioelectrical rhythms in the brain sensomotor regions. The use of rispolept caused positive changes on treatment day 15; its adverse reactions were noted rarely and required no drug discontinuance.

About the Authors

V. P. Zykov
Russian Medical Academy of Postgraduate Education
Russian Federation

S. A. Kabanova
Russian Medical Academy of Postgraduate Education
Russian Federation


1. <div><p>Зыков В.П. Лечение тиков и синдрома Туретта у детей. Альманах «Исцеление». М., 2000; 4: 181-3.</p><p>Гузева В.И., Чутко Л.С., Катышева Н.В. и др. Лечение тикозных гиперкинезов у детей с помощью метода биоуправления. Рос. вестн. перинатол. и педиатр. 1996; 41(2): 25.</p><p>Пелехова О.Л. Современные подходы к диагностике и лечению тиков и тикоподобных гиперкинезов. Экспер. и клин. мед. 1999; 1: 63-5.</p><p>Чутко Л. С. Клиническая оценка и лечение тикозных гиперкинезов. Автореф. дис. ... канд. мед. наук. СПб., 1996; 23.</p><p>Jancovic J. Tourette's syndrome. N Engl J Med 2001; 345(16): 1184-92.</p><p>Sindo J., Jorgenson J.I. Treatment of tics in Tourette syndrome with atypical antipsychotic drugs. Ugeskr Laeger 2002; 164(32): 3755-9.</p><p>Zimenes-Zimenes F.J., Garsia-Ruiz P.J. Pharmacological options for the treatment of Tourette's disorder. Drugs 2001; 61(15): 2207-20.</p><p>Калинин В.В. К проблеме отграничения новых нейролептиков от классических. Сопоставление клинического и нейрохимического подхода. Психиатр. и психофармакотер. 2001; 3(4): 129-31.</p><p>Benkelfat C., Murphy D., Zonar J. et al. Clomipramine in Clomipramine: further evidence for a serotonergic mechanism of action. Arch Gen Psychiat 1989; 46: 23-8.</p><p>Casey D.E. Paradoxical tardive dyskinesia. In: Disorders of Movement in Psychiatry and Neurology. Cambridge: Blackwell, 1992; 67-9.</p><p>Dion Y., Annable L., Sandor P., Chouinard G. Risperidone in the treatment of Tourette syndrome: a double-blind, placebo-controlled trial. J Clin Psychopharmacol 2002; 22(1): 31-9.</p><p>Fortaine K., Choninard G. An open clinical trial of fluoxetine in the treatment of obsessive- compulsive disorder. J Clin Psychopharmacol 1986; 6: 98-101.</p><p>Czobor P., Volavka J., Sheilman B. et al. Antipsychotic-induced weight gain and therapeutic response: a differential association. J Clin Psychopharmacol 2002; 22: 244-51.</p><p>Manos M.J., Short E.J., Findling R.L. Differential effectiveness of methylphenidate and Adderall in school-age youths with attention- deficit/ hyperactivity disorder J Am Acad Child Adolesc Psychiatry 1999; 38(7): 813-9.</p><p>Klett C., Caffey E. Weight changes during treatment with phenothiazine derivatives. J Neuropshychiar 1960; 2: 102-8.</p><p>Planansky K., Heilizer F. Weight changes in relation to the characteristic of patients on chlorpromazine. J Clin Exp Psychopathol Q Rev Psychiat Neurol 1959; 20: 53-7.</p><p>Дахаева Л.Н. Компьютерное нейрокартирование головного мозга при синдроме Жиль де ла Туретта у детей. Автореф. дис. ... канд. мед. наук. М., 1998; 9-10,19.</p><p>Keck P.E. Jr., McElroy S.L., Arnold L.M. Ziprasidone: a new atypical antipsychotic. Expert Opin Pharmacother 2001; 2(6): 1033-42.</p></div><br />

For citation:

Zykov V.P., Kabanova S.A. Clinical electroencephalographic criteria for the efficacy of rispolept therapy in children with Tourette's syndrome. Neurology, Neuropsychiatry, Psychosomatics. 2010;2(2):46-49. (In Russ.)

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