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Correction of cholinergic deficiency in patients with vascular dementia

https://doi.org/10.14412/2074-2711-2010-82

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Abstract

The efficacy of the acetylcholine esterase inhibitor reminil was studied in vascular dementia (VD). Eighty-four (54 men and 30 women) patients aged 60-85 years with the verified diagnosis of VD were followed up. Their mean age was 65±4,3 years; the mean duration of VD after its diagnosis was 2,3 years (that after firstly detected VD was less than 4 years). Primary examination before therapy showed that all the patients had cognitive disorders characteristic of VD concurrent with varying motor disorders. Reminil showed a significant effect against the symptoms of VS within 1,5-2 months after initiation of its administration and when the therapeutic effect of the drug was achieved. Improved cognitive functions were preserved during a 12-month follow-up. Owing to its double mechanism of action, reminil is active against cognitive and behavioral disorders in a wide circle of patients with dementia, well tolerated, and causes no serious adverse reactions.

About the Author

O. I. Mokhova
Treatment and Rehabilitation Center, Russian Agency for Health Care
Russian Federation
Moscow


References

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For citation:


Mokhova O.I. Correction of cholinergic deficiency in patients with vascular dementia. Neurology, Neuropsychiatry, Psychosomatics. 2010;2(2):40-45. (In Russ.) https://doi.org/10.14412/2074-2711-2010-82

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ISSN 2074-2711 (Print)
ISSN 2310-1342 (Online)