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Correction of cholinergic deficiency in patients with vascular dementia

https://doi.org/10.14412/2074-2711-2010-82

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Abstract

The efficacy of the acetylcholine esterase inhibitor reminil was studied in vascular dementia (VD). Eighty-four (54 men and 30 women) patients aged 60-85 years with the verified diagnosis of VD were followed up. Their mean age was 65±4,3 years; the mean duration of VD after its diagnosis was 2,3 years (that after firstly detected VD was less than 4 years). Primary examination before therapy showed that all the patients had cognitive disorders characteristic of VD concurrent with varying motor disorders. Reminil showed a significant effect against the
symptoms of VS within 1,5-2 months after initiation of its administration and when the therapeutic effect of the drug was achieved. Improved cognitive functions were preserved during a 12-month follow-up. Owing to its double mechanism of action, reminil is active against cognitive and behavioral disorders in a wide circle of patients with dementia, well tolerated, and causes no serious adverse reactions.

About the Author

Olga Igorevna Mokhova



References

1. <div><p>Международная статистическая классификация болезней и проблем, связанных со здоровьем. Десятый пересмотр (МКБ-10). Женева, 1995;1(1):510-1.</p><p>Вахнина Н.В., Никитина Л.Ю., Парфенов В.А., Яхно Н.Н. Постинсультные когнитивные нарушения. Инсульт 2008; 22: 16-21.</p><p>Madureira S., Guerreiro M., Ferro J.M. Dementia and cognitive impairment three months after stroke. Eur J Neurol 2001; 8(6): 621-7.</p><p>Henon H., Pasquier F., Leys D. Poststroke dementia. Cerebrovasc Dis 2006; 22(1): 61-70.</p><p>Яхно Н.Н., Левин О.С., Дамулин И.В. Сопоставление клинических и МРТ-данных при ддисциркуляторной энцефалопатии. Сообщение 2: Когнитивные нарушения. Неврол. журн. 2001; 6(3): 10-9.</p><p>Altieri M., Di Piero V., Pasquini M. Delayed poststroke dementia: a 4-year follow-up study. Neurology 2004; 62(12): 2193-7.</p><p>Мелентьев А.С., Гасилин В.С., Гусев Е.И. и др. Гериатрические аспекты внутренних болезней. М.: Medi Net, 1995.</p><p>Левин О.С. Диагностика и лечение деменции в клинической практике. М.: Медпресс Информ, 2010.</p><p>Пожилой больной. Сост. Г.Н. Милютина. Петрозаводск: Центр информ.-библ. поддержки здравоохранения, 2003.</p><p>Аксаментов Г.В. Клинические и функциональные особенности пациентов гериатрического стационара. Здравоохранение 2002.</p><p>Левин О.С., Дамулин И.В. Диффузные изменения белого вещества (лейкоареоз) и проблема сосудистой деменции. В кн.: Достижения в нейрогериатрии. Под ред. Н.Н. Яхно, И.В. Дамулина. 1995; 2: 189-231.</p><p>Ritchie C.W. et al. Therapeutic strategies in Dementia. Clinical Publishing. Oxford, 2007.</p><p>Мищенко Т.С. Современные подходы к лечению больных дисциркуляторной энцефалопатией. Киев: Здоров'я України, 2007.</p><p>Roman G. Vascular dementia: Distinguishing characteristics, treatment, and prevention. JAGS 2003; 51: S296-S304.</p><p>Launer L.J., Masaki K., Petrovitch H. et al. The association between midlife blood pressure level and late-life cognitive function. The Honolulu-Asia Aging Study. JAMA 1995; 274(23).</p><p>Roman G.C., Tatemichi T.K., Erkinjuntti T. et al. Vascular dementia: diagnostic criteria for research studies. Report of the NINDS-AIREN International Workshop. Neurology 1993; 43(2): 250-60.</p><p>Hachinski V. Vascular dementia: a radical redefinition. Dementia 1994; 5(3-4): 130-2.</p><p>Erkinjuntti T., Inzitari D., Pantoni L. Research criteria for subcortical vascular dementia in clinical trials. J Neural Transm 2000; 59(Suppl. 2): 23-30.</p><p>Patterson C., Feightner J., Garcia A. General risk factors for dementia: a systematic evidence review. Alzheimers Dement 2007; 3(4).</p><p>Дамулин И.В. Болезнь Альцгеймера и сосудистая деменция. М., 2002.</p><p>Elias M.F., Wolf P.A., D'Agostino R.B. et al. Untreated blood pressure level is inversely reated to cognitive functioning: the Framingham Study. Am J Epidemiol 1993; 138(6): 353-64.</p><p>Ruitenberg A., Skoog I., Ott A. et al. Blood pressure and risk of dementia: results from the Rotterdam study and the Gothenburg H-70 Study. Dement Geriatr Cogn Disord 2001; 12(1): 33-9.</p><p>Захаров В.В. Современные аспекты фармакотерапии деменции. Неврол. журн. 2006; 2.</p><p>Дворецкий Л.И., Кузнецова О.П. Трудности диагностики у лиц пожилого возраста. Тер. арх. 1995; 10: 35-9.</p></div><br />


For citation:


Mokhova O.I. Correction of cholinergic deficiency in patients with vascular dementia. Neurology, Neuropsychiatry, Psychosomatics. 2010;2(2):40-45. (In Russ.) https://doi.org/10.14412/2074-2711-2010-82

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ISSN 2074-2711 (Print)
ISSN 2310-1342 (Online)