Neurology, Neuropsychiatry, Psychosomatics

Advanced search

Childhood dysphasias in patients with late sequelae of perinatal central nervous system lesion

Full Text:


The aim of the study was to explore condition of the nervous system in different types of childhood dysphasia (CD), to compare the brain bio-electric activity to the level of cerebral blood flow, severity of neurological disorders, and neuropsychophysiological parameters, to identify the intact links of brain organization in children with minimal brain dysfunction (MBD), sensorineural hearing loss (SNHL), and spastic forms of infantile cerebral palsy (ICP).
Patients and methods. 505 Children aged 4–8 years were examined: 218 with MBD, 73 with SNL, and 214 with spastic forms of ICP. The patients were divided into two groups: preschool age, 4–6 years (110 children with MBD, 29 with SNHL, and 116 with ICP) and early school age, 7–8 years (108 children with MBD, 44 with SNHL, and 98 with ICP). The group of preschool age children with spastic forms of ICP comprised 42 children with double hemiplegia (DHP), 36 with spastic hemiplegia (SHP), and 38 with spastic diplegia (SDP). The early school age group comprised 32 children with DHP, 37 with SHP, and 29 with SDP.
All children underwent general clinical and neurological examination, computerized electroencephalography (EEG), neuropsychophysiological and speech testing, transcranial Doppler ultrasonography, and if required, computed tomography (CT) and magnetic resonance imaging (MRI) of the brain. To clarify the mechanisms of cerebral disintegration in children with signs of epileptiform activity, in the day-time EEG 
recording, extended video-EEG monitoring was performed for 12–14 h with mandatory recording of nocturnal sleep. Condition of the audio-verbal sphere in children with SNL was examined using an original computer program, Speech_Audiometry.

Results and discussion. The rate of the motor type CD upon MBD was demonstrated to be 77.6%; the mixed type CD predominated in children with SNHL and ICP: 82.2 and 66.2%, respectively. Upon spastic forms of ICP, a combination of CD with symptoms of dysarthria and oral dyspraxia was detected in 84% of cases. A mutually aggravating effect of the main clinical manifestations on the nature and intensity of speech development disorders was revealed, especially when a child had two or more active pathological processes in the CNS. A number of clinical-neurophysiological and neuropsychological correlations with different types and versions of CD were found, which allows one to perform computerized support of rehabilitation of these children and to develop differentiated approaches to treatment. 

About the Authors

S.Yu. Lavrick
Irkutsk State Medical Academy of Postgraduate Education, Ministry of Health of the Russian Federation, Irkutsk, Russia; Irkutsk State Medical University, Ministry of Health of the Russian Federation, Irkutsk, Russia
Russian Federation

S.V. Domitrak
Irkutsk State Medical University, Ministry of Health of the Russian Federation, Irkutsk, Russia
Russian Federation

V.V. Shprakh
Irkutsk State Medical Academy of Postgraduate Education, Ministry of Health of the Russian Federation, Irkutsk, Russia;
Russian Federation


1. Бенилова СЮ. Анализ клинико-анамнестических данных при дисфазии и афазии развития у дошкольников. Вопросы психического здоровья детей и подростков. 2008;2(8):42-54. [Benilova SYu. The analysis the kliniko-anamnesticheskikh of data at a dysphasia and aphasia of development in preschool children. Voprosy psikhicheskogo zdorov'ya detei i podrostkov. 2008;2(8):42–54. (In Russ.)]

2. Заваденко НН. Гиперактивность и дефицит внимания в детском возрасте. Москва: Академия; 2005. 256 с. [Zavadenko NN. Giperaktivnost' i defitsit vnimaniya v detskom vozraste [Hyperactivity and deficiency of attention at children's age]. Moscow: Akademiya; 2005. 256 p.]

3. Заваденко НН, Козлова ЕВ, Колтунов ИЕ. Дисфазия развития: оценка эффективности лекарственной терапии. Журнал неврологии и психиатрии им. С.С. Корсакова. 2012;112(7-2):90-5. [Zavadenko NN, Kozlova EV, Koltunov IE. Developmental dysphasia: assessment of the drug treatment efficacy. Zhurnal nevrologii i psikhiatrii im. S.S. Korsakova. 2012;112(7–2):90–5. (In Russ.)]

4. Немкова СА. Когнитивные нарушения при детском церебральном параличе. Москва: Триада-Х; 2013. 440 с. [Nemkova SA. Kognitivnye narusheniya pri detskom tserebral'nom paraliche [Cognitive violations at a children's cerebral palsy]. Moscow: Triada-Kh; 2013. 440 p.]

5. Чутко ЛС, Пальчик АБ, Кропотов ЮД. Синдром нарушения внимания с гиперактивностью у детей и подростков. Санкт-Петербург: Издательский дом СПбМАПО; 2004. 112 с. [Chutko LS, Pal'chik AB, Kropotov YuD. Sindrom narusheniya vnimaniya s giperaktivnost'yu u detei i podrostkov [Syndrome of violation of attention with a hyperactivity at children and teenagers]. St- Pеtersburg: Izdatel'skii dom SPbMAPO; 2004. 112 p.]

6. Rapin I. Children with Brain Dysfunction. Neurology, Cognition, Language and Behavior. Int Child Neurol Series. New York: Raven Press; 1982. 248 p.

7. Tan XST. Developmental dysphasia. Amsterdam: Suyi Publicaties; 2005. 357 p.

8. Ньокиктьен Ч. Детская поведенческая неврология. В 2 томах. Т. 1. Москва: Теревинф; 2009. 288 с. [Nyokiktyen Ch. Detskaya povedencheskaya nevrologiya [Children's Behavioral Neuroscience]. In 2 vol. Moscow: Terevinf; 2009. Vol. 1. 288 p.]

9. Никитин ЮМ. Ультразвуковая диагностика. Москва: Спектромед; 1995. 426 с. [Nikitin YuM. Ul'trazvukovaya diagnostika. [Ultrasonic diagnostics.]. Moscow: Spektromed; 1995. 426 p.]

10. Njiokiktjien C. Differences in vulnerability between the hemispheres in early childhood and adulthood. Fiziol Cheloveka. 2006 Jan- Feb;32(1):45–50.

11. Лаврик СЮ, Домитрак СВ, Шпрах ВВ, Колесова ЛВ. Роль комплексной метаболической терапии в процессе нейрореабилитации детей с сенсоневральной тугоухостью. Тихоокеанский медицинский журнал. 2013;4:46-9. [Lavrik SYu, Domitrak SV, Shprakh VV, Kolesova LV. Role of complex metabolic therapy in the course of neurorehabilitation of children with sensonevralny relative deafness. Tikhookeanskii meditsinskii zhurnal. 2013;4:46–9. (In Russ.)]

12. Лаврик СЮ, Стародубцев АВ, Шпрах ВВ. Возрастные нормативы и особенности развития когнитивных, сенсомоторных и речевых процессов у детей дошкольного и раннего школьного возраста по данным компьютерного нейропсихофизиологического тестирования. Сибирский медицинский журнал (г. Иркутск). 2005;53(4):72-6. [Lavrick SY, Starodubtsev AV, Shprakh VV. Age Standards and peculiarities of cognitive, sensomotor and speech development in preschool and early school age by computer neuropsychophysiological testing. Sibirskii meditsinskii zhurnal (Irkutsk). 2005;53(4):72–6. (In Russ.)]


For citations:

Lavrick S., Domitrak S., Shprakh V. Childhood dysphasias in patients with late sequelae of perinatal central nervous system lesion. Neurology, Neuropsychiatry, Psychosomatics. 2014;6(1):16-20. (In Russ.)

Views: 1147

Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 License.

ISSN 2074-2711 (Print)
ISSN 2310-1342 (Online)