Preview

Neurology, Neuropsychiatry, Psychosomatics

Advanced search

Association of the dopamine receptor (DRD4, DAT) gene polymorphisms with vital exhaustion in an open population among 25—64-year-old men (Novosibirsk): Epidemiological study according to the WHO MONICA-psychosocial program

https://doi.org/10.14412/2074-2711-2012-363

Abstract

Objective: to study the association of the DRD4, DAT genes with vital exhaustion in an open 25—64-old-year male population. A random representative sample of 657 men aged 25—64 years, living in one of the Novosibirsk districts was examined within the WHO MONICA project in 1994. The MONICA-MOPSY test was used to estimate the level of vital exhaustion. The examined DRD4, DAT gene Polymorphisms were genotypes in the Laboratory of Molecular Genetic Studies, Therapy Research Institute, Siberian Branch, Russian Academy of Medical Sciences (Novosibirsk). Results. The genotype containing allele 7 in the dopamine receptor subtype 4 (DRD4) gene, as well as genotype 9/9 in the dopamine-transporter protein (DAT) gene are significantly associated with the high level of vital exhaustion. Conclusion. The vital exhaustion is significantly associated with certain DRD4, DAT gene polymorphisms in the open 25—64-year-old male population of Novosibirsk.

References

1. <div><p>Аppels A., Mulder P. Excess fatigue as a precursor of myocardial infarction. Eur Heart J 1988;9:758—64.</p><p>Kuller L.H. Prodromata of sudden death and myocardial infarction. Adv Cardiol 1978;25:61—72.</p><p>Rissanen V., Romo M., Siltanen P. Premonitory symptoms and stress factors preceding sudden death from ischaemic heart disease. Act Med Scand 1978;204:389—96.</p><p>Alonzo A., Simon A., Feinleib M. Prodromata of myocardial infarction and sudden death. Circulation 1975;52:1056—62.</p><p>Fraser G.E. Sudden Death in Auckland. Austr NZJ Med 1978;8:490—9.</p><p>Kinlen L.J. Incidence and presentation of myocardial infarction in an English community. Br Heart J 1973;35:616—22.</p><p>Brown G.W., Harris T.O., Eales M.J. Aetiology of anxiety and depressive disorders in an inner-city population. 2. Comorbidity and adversity. Psychol Med 1993;23:155—65.</p><p>Kendler K.S., Walters E.E., Kessler R.C. The prediction of length of major depressive episodes: results from an epidemiological sample of female twins. Psychol Med 1997;27: 107—17.</p><p>Kessler R.C. The effects of stressful life events on depression. Annu Rev Psychol 1997;48:191—214.</p><p>Kaprio J., Koskenvuo M., Langinvainio H. et al. Social and genetic influences on drinking patterns of adult men: a study of 5638 Finnish twin brothers. Alcohol 1987;1(Suppl.):373—7.</p><p>Li J., Precht D.H., Mortensen P.B. et al. Mortality in parents after death of a child in Denmark: a nationwide follow-up study. Lancet 2003;361:363—7.</p><p>Cohen S., Tyrrell D.A., Smith A.P. Psychological stress and susceptibility to the common cold. N Engl J Med 1991;325: 606—12.</p><p>KivimKki M., Vahtera J., Elovainio M. et al. Death or illness of a family member, violence, interpersonal conflict, and financial difficulties as predictors of sickness absence: longitudinal cohort study on psychological and behavioral links. Psychosom Med 2002;64:817—25.</p><p>KivimKki M., Vahtera J., Pentti J. et al. Factors underlying the effect of organisational downsizing on health of employees: longitudinal cohort study. BMJ 2000;320:971—5.</p><p>Jose B.S., van Oers H.A., van de Mheen H.D. et al. Stressors and alcohol consumption. Alcohol 2000;35:307—12.</p><p>Goldstein B.I., Abela J.R., Buchanan G.M. et al. Attributional style and life events: a diathesis-stress theory of alcohol consumption. Psychol Rep 2000;87:949—55.</p><p>Kivimäki M., Elovainio M., Kokko K. et al. Hostility, unemployment and health status: testing three theoretical models. Soc Sci Med 2003;56:2139—52.</p><p>Elovainio M., Jokela M., Kivimäki M. et al. Genetic Variants in the DRD2 Gene Moderate the Relationship Between Stressful Life Events and Depressive Symptoms in Adults: Cardiovascular Risk in Young Finns Study Psychosomatic Med 2007;69:391—5.</p><p>Pani L., Porcella A., Gessa G.L. The role of stress in the pathophysiology of the dopaminergic system. Mol Psychiatry 2000;5:14—21.</p><p>Paes de Sousa M., Tropa J. Evaluation of the efficacy of amineptine in a population of I,229 depressed patients: results of a multicenter study carried out by 135 general practitioners. Clin Neuropharmacol 1989;12(Suppl. 2): S77—S86.</p><p>Baron M. Manic-depression genes and the new millennium: poised for discovery. Mol Psychiatry 2002;7:342—58.</p><p>Morley K.I., Hall W.D., Carter L. Genetic screening for susceptibility to depression: can we and should we? Aust N Z J Psychiatry 2004;38:73—80.</p><p>Souery D., Lipp O., Mahieu B. et al. Association study of bipolar disorder with candidate genes involved in catecholamine neurotransmission: DRD2, DRD3, DAT1, and TH genes. Am J Med Genet 1996;67:551—5.</p><p>Stober G., Jatzke S., Heils A. et al. Insertion/deletion variant (-141C Ins/Del) in the 5' regulatory region of the dopamine D2 receptor gene: lack of association with schizophrenia and bipolar affective disorder. Short communication. J Neural Transm 1998;105:101—9.</p><p>WHO Proposal for the Multinational Monitoring of Trends in cardiovascular disease. Geneva, 1985.</p><p>WHO MONICA Psychosocial Optional Study. Suggested Measurement Instruments. Copenhagen: WHO Regional Office for Europe, 1988.</p><p>WHO MONICA Project prepared by Kuulasmaa K. et al. Baseline population survey data book. MONICA Memo 178 A. Helsinki, 1990.</p><p>Смит К., Калко С., Кантор Ч. Пульс-электрофорез и методы работы с большими молекулами ДНК. Анализ генома. Под ред. К. Дейвиса. Пер. с англ. М.: Мир, 1990;58-94.</p><p>Маниатис Т., Фрич Э., Сэмбрук Дж. Методы генетической инженерии. Молекулярное клонирование. М.: Мир, 1984;357 с.</p><p>Nanko S., Hattori M., Ikeda K. et al. Dopamone D4 receptor polymorphism and schizophrenia. Lancet 1993;341:689-90.</p><p>Mitchell R.J., Howlett S., Earl L. et al. Distribution of the 3’ VNTR polymorphism in the human dopamine transporter gene in world populations. Human Biology 2000;72(2):295-304.</p><p>SPSS: искусство обработки информации. Анализ статистических данных и восстановление скрытых закономерностей. Пер. с нем. А. Бююль, П. Цёфель. СПб.: DiaSoftЮП, 2002;608 с.</p><p>Glants С. Biomedical statistics. Transl. From eng. М.: Practika, 1998;459 c.</p><p>Keltikangas-Järvinen L., Elovainio M., Kivimäki M. et al. Association Between the Type 4 Dopamine Receptor Gene Polymorphism and Novelty Seeking. Psychosom Med 2003;65:471—6.</p><p>Herbst J.H., Zonderman A.B., McCrae R.R. et al. Do the dimensions of the temperament and character inventory map a simple genetic architecture? Evidence from molecular genetics and factor analysis. Am J Psychiatry 2000;157:1285—90.</p><p>Ekelund J., Lichtermann D., Järvelin M.-R. et al. Association between novelty seeking and the type 4 dopamine receptor gene in a large Finnish cohort sample. Am J Psychiatry 1999;156:1453—5.</p><p>Lahti R.A., Lahti A.C. Images in neuroscience. Clinical genetics. V. Association of genetic and personality characteristics. Am J Psychiatry 1997;154(11):1496.</p><p>Trimble M.R. Biological Psychiatry. London: John Wiley and Sons, 1996.</p><p>Gelenter J., Kranzler H.R., Satel S.L. et al. Genetic association between dopamine transporter protein alleles and cocaine-induced paranoia. Neuropsychopharmacol 1994;11(3):195—200.</p><p>Ebstein R.P., Nemanov L., Klotz I. et al. Additional evidence of an association between the dopamine D4 dopamine receptor (D4DR) exon III repeat polymorphism and the human personality trait of novelty seeking. Mol Psychiatry 1997;2(6):472—7.</p><p>Noble E.P., Ozkaragoz T.Z., Ritchie T.L. et al. D2 and D4 dopamine receptor polymorphisms and personality. Am J Med Genet 1998;81(3):257—67.</p><p>Ono Y., Manki H., Yoshimura K. et al. Association between dopamine D4 receptor (D4DR) exon III polymorphism and novelty seeking in Japanese subjects. Am J Med Genet 1997;74(5):501—3.</p><p>Vanderberg D.G., Persico M., Hawkins A.L. et al. Human dopamine transporter gene (DAT1) maps to chromosome 5p15.3 and displays a VNTR. Genomics 1992;14:1104—6.</p><p>Segman R.H., Cooper-Kazaz R., Macciardi F. et al. Association between the dopamine transporter gene and posttraumatic stress disorder. Mol Psychiatry 2002;7(8):903—7.</p><p>Sander T., Harms H., Podschus J. et al. Allelic association of a dopamine transporter gene polymorphism in alcohol dependence with withdrawal seizures or delirium. Biol Psychiatry 1997;41(3):299—304.</p><p>Sabol S.Z., Nelson M.L., Fisher C. et al. A genetic association for sigarette smoking behavior. Health Psych 1999;18:7—13.</p><p>Lerman C., Caporaso N.E., Audrain J. et al. Evidence suggesting the role of specific genetic factors in sigarette smoking. Health Psych 1999;18:14—20.</p><p>Gelenter J., Kranzler H.R., Satel S.L. et al. Genetic association between dopamine transporter protein alleles and cocaine-induced paranoia. Neuropsychopharmacol 1994;11(3):195—200.</p></div><br />


Review

Views: 831


Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 License.


ISSN 2074-2711 (Print)
ISSN 2310-1342 (Online)