Preview

Neurology, Neuropsychiatry, Psychosomatics

Advanced search

Use of amelotex to treat patients with acute musculoskeletal pain in the back and grade 1 essential hypertension

https://doi.org/10.14412/2074-2711-2011-166

Full Text:

Abstract

Among nonsteroidal anti-inflammatory drugs, meloxicam has a slight effect on blood pressure (BP). Objective: to study the efficacy and safety of amelotex in acute musculoskeletal pain in the lumbosacral region and essential hypertension (EH). Subjects and methods. An open-label comparative trial of the safety and efficacy of amelotex (meloxicam injectable dosage form) in an intramuscular dose of 15 mg/day and diclofenac sodium in an intramuscular dose of 75 mg/day was conducted in 120 patients with acute muscu-
loskeletal pain in the lumbosacral region and grade 1 EH. Results. Amelotex was as effective as diclofenac sodium in reducing the intensity of pain and the degree of vertebral syndrome and decreasing the restricted daily activity of patients with acute lumbalgia and concomitant grade 1 EH. Ten-day use of amelotex in the above dose caused
no significant BL elevation.
Conclusion. Amelotex was observed to be highly effective and well tolerated in patients with grade 1 EH who were treated for acute muscu-
loskeletal pain in the back.

References

1. <div><p>Bergenudd H., Nilsson B. Back pain in middle age; occupational workload and psychologic factors: an epidemiologic survey. Spine 1988;13:58-60.</p><p>Papageorgiou A.C., Croft P.R., Ferry S. et al. Estimating the prevalence of low back pain in the general population. Evidence from the South Manchester Back Pain Survey. Spine 1995;20:1889-94.</p><p>Walsh K., Cruddas M., Coggon D. Low back pain in eight areas of Britain. J Epidemiol Community Health 1992;46:227-30.</p><p>Statistisches Bundesamt. Health report for Germany: Federal Health Bulletin. Wiesbaden: Metzler-Poeschel; 1998.</p><p>Schneider S., Mohnen S., Schiltenwolf M. et al. Comorbidity of low back pain: Representative outcomes of a national health study in the Federal Republic of Germany. Eur J Pain 2007;11:387-97.</p><p>Парфенов В.А. Повышение артериального давления и гипотензивная терапия при инсульте. Сист гипертенз 2004;06(1):1-8.</p><p>Collins R., Peto R., MacMahon S. et al. Blood pressure and coronary heart disease. Lancet 1990;335:827-38.</p><p>Захаров В.В., Яхно Н.Н. Когнитивные расстройства в пожилом и старческом возрасте. Методическое пособие для врачей. М., 2005;71 с.</p><p>Захаров В.В., Яхно Н.Н., Локшина А.Б. и др. Деменции. Руководство для врачей. М.: МедПресс-информ, 2010;264 с.</p><p>Старчина Ю.А., Парфенов В.А, Чазова И.Е. и др. Когнитивные функции и эмоциональное состояние больных, перенесших инсульт, на фоне антигипертензивной терапии. Журн неврол и психиатр. Инсульт 2005;(15):39-44.</p><p>Starr J.M., Whalley L.J., Inch S. et al. Blood pressure and cognitive functions in healthy old people. J Am Geriatr Soc 1993;41:153-6.</p><p>Schnitzer T.J., Ferraro A., Hunsche E. et al. A comprehensive review of clinical trials on the efficacy and safety of drugs for the treatment of low back pain. J Pain Sympt Manag 2004;28:72-95.</p><p>Van Tulder M., Becker А., Bekkering T. et al. European guidelines for the management of acute nonspecific low back pain in primary care. Eur Spine J 2006;15(Suppl. 2):169-91.</p><p>Van Tulder M.W., Scholten R.J., Koes B.W. et al. Non-steroidal anti-inflammatory drugs for low back pain. Cochrane Database of Systematic Reviews 2005;(2):CD000396.</p><p>Vane J.R. Inhibition of prostaglandin synthesis as a mechanism of action for aspirin-like drugs. Nat New Biol 1971;231(25):232-5.</p><p>Johnson A.G., Nguyen T.V., Day R.O. Do nonsteroidal anti-inflammatory drugs affect blood pressure? A meta-analysis. Ann Intern Med 1994;121:289-300.</p><p>Pope J.E., Anderson J.J., Felson D.T. A meta-analysis of the effects of nonsteroidal anti-inflammatory drugs on blood pressure. Arch Int Med 1993;153:477-84.</p><p>C., Reid C., Aw T. et al. Do COX-2 inhibitors raise blood pressure more than nons-elective NSAIDs and placebo? An updated meta-analysis Do COX-2 inhibitors raise blood pressure more than nonselective NSAIDs and placebo? J Hypertens 2009;27(12):2332-41.</p><p>Linton A.L. Adverse effects of NSAIDs on renal function. Can Med Ass J 1984;131:189-91.</p><p>Perazella M. COX-2 selective inhibitors: analysis of the renal effects. Expert Opin Drug Saf 2002;1:53-64.</p><p>Friedewald V., Ram V., Wesson D. et al. The Editor's Roundtable: Effect of Nonsteroidal Anti-Inflammatory Drugs on Blood Pressure. Am J Cardiol 2010;105:1759-67</p><p>Подчуфарова Е.В., Яхно Н.Н. Боль в спине. М.: ГЭОТАР-Медиа, 2009;356 с.</p><p>Эрдес Ш.Ф. Неспецифическая боль в нижней части спины. Клинические рекомендации для участковых терапевтов и врачей общей практики. М.: КомплектСервис, 2008;70 с.</p><p>NICE - National Institute for Health and Clinical Excellence 44345/44345.pdf</p></div><br />


For citation:


Podchufarova E.V., Yakhno N.N. Use of amelotex to treat patients with acute musculoskeletal pain in the back and grade 1 essential hypertension. Neurology, Neuropsychiatry, Psychosomatics. 2011;3(3):46-52. (In Russ.) https://doi.org/10.14412/2074-2711-2011-166

Views: 473


Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 License.


ISSN 2074-2711 (Print)
ISSN 2310-1342 (Online)