Preview

Neurology, Neuropsychiatry, Psychosomatics

Advanced search

THE PROBLEMS OF THE PATHOGENESIS AND TREATMENT OF ALCOHOLIC POLYNEUROPATHY

https://doi.org/10.14412/2074-2711-2009-43

Abstract

The pathogenetic, clinical, diagnostic, and therapeutic aspects of alcoholic polyneuropathies, the most common nervous system complication in alcoholism, are considered. Two possible pathogenetic mechanisms of polyneuropathy: the direct toxic effect of ethanol and its metabolites and malnutrition with deficiency of B-group vitamins, including thiamine, are discussed. The use of B-group vitamins and α-lipoic acid preparations is recommended as pathogenetic therapy. The adjuvant analgesics - anticonvulsants and antidepressants are used to treat neuropathic pain.

About the Authors

O. E. Zinov'eva
I.M. Sechenov Moscow Medical Academy
Russian Federation


O. I. Angel'cheva
I.M. Sechenov Moscow Medical Academy
Russian Federation


References

1. <div><p>Vittadini G., Buonocore M., Colli G. et al. Alcoholic polyneuropathy: a clinical and epidemiological study Alcohol and Alcoholism 2001; 36(5):393-400.</p><p>Ангельчева О. И. Алкогольная полиневропатия. Неврол журн 2006; 11(1):51-5.</p><p>Ammendola A., Gemini D., Iannacore S. et al. Gender and peripheral neuropathy in chronic alcoholism: a clinical - electroneurographic study. Alcohol and Alcoholism 2001; 35(4):388-71.</p><p>Koike H., Iijima M., Sugiura M. et al. Alcoholic neuropathy is clinicopathologically distinct from thi- amine-deficiency neuropathy. Ann Neurol 2003; 54(1):19-29.</p><p>Kucera P., Balaz M., Varsik P. et al. Pathogenesis of alcoholic neuropathy. Bratisl Lek Listy 2002; 103(1):26-9.</p><p>Singleton C.K., Martin P.R. Molecular mechanisms of thiamine utilization. Cur Mol Med 2001; 1(2):197-207.</p><p>Windebank A.J. Polyneuropathy due to nutritional deficiency and alcoholism. In: Dyck P.J. Thomas P.K. Griffin J.W. Peripheral Neuropathy. 3rd ed. Philadelphia, WB Saunders Co, 1993: 1310-21.</p><p>Ortiz-Plata A., Palencia G., Garcia E. et al. Ultrastructural changes in limb distal nerves of rats with alcoholism and/or malnutrition before and after dietary correction. J Appl Toxicol 1998; 18(2):89-92.</p><p>Koike H., Mori K., Misu K. et al. Painful alcoholic polyneuropathy with predominant small-fiber loss and normal thiamine status. Neurology 2001; 56(12):1727-32.</p><p>Monforte R., Estruch R., Valls-Sole J. et al. Autonomic and peripheral neuropathies in patients with chronic alcoholism. A dose-related toxic effect of alcohol. Arch Neurol 1995; 52(1):45-51.</p><p>Victor M., Ropper A.H. The Adams and Victors Principles of Neurology. Diseases of the nervous system due to nutritional deficiency. Seventh Ed. McGraw-Hill Inc 2001; 1205-32.</p><p>Behse F., Buchthal F. Alcoholic neuropathy: clini- cal, electrophysiological, and biopsy findings. Ann Neurol 1977; 2:95-110.</p><p>Ангельчева О.И., Зиновьева О.Е., Яхно Н.Н. Нервно-мышечные нарушения при хрониче ском алкоголизме. М.: МЕД-пресс, 2009.</p><p>Woelk H., Lehrl S., Bitsch R. et al. Benfotiamine in treatment of alcoholic polyneuropathy: an 8-week randomized controlled study (BAP I Study). Alcohol and Alcoholism 1998; 33(6):631-8.</p><p>Бустаманте Д., Лодж Д., Маркоччи Л. и др. Метаболизм α-липоевой кислоты в печени при различных формах патологии. Межд. мед. журн. 2001; 2:133-42.</p><p>Кукушкин М.Л., Хитров Н.К. Общая патология боли. М.: Медицина, 2004.</p><p>Яхно Н.Н. Применение противосудорожных препаратов для лечения хронических неврогенных болевых синдромов. В кн.: Антиконвульсанты в психиатрической и неврологической практике. СПб.: МИА, 1994; 317-25.</p></div><br />


Review

Views: 819


Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 License.


ISSN 2074-2711 (Print)
ISSN 2310-1342 (Online)