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Diagnosis and treatment of acute vertigo in emergency neurological practice

https://doi.org/10.14412/2074-2711-2025-4-134-140

Abstract

The diagnosis and treatment of acute vertigo in emergency neurological practice are among the most pressing issues in modern neurology. The diagnosis of vestibular system disorders remains at a low level. Many patients with peripheral vestibular system damage and vestibular migraine are misdiagnosed with stroke and transient ischaemic attacks, chronic vertebrobasilar insufficiency, and cervical osteochondrosis. Acute vestibular vertigo is in most cases associated with pathology of the peripheral vestibular system and vestibular migraine, and much less often with stroke or transient ischaemic attacks in the vertebrobasilar arterial system. To make a diagnosis, it is especially important to conduct a clinical neurovestibular examination, including positional tests for benign paroxysmal positional vertigo, the Halmagyi (head impulse) test, assessment of oblique deviation, severity of trunk ataxia and hearing impairment, as well as the use of modern neuroimaging methods. Modern treatment regimens have been developed for each of the nosological forms. A low-dose combination drug of cinnarizine 20 mg + dimenhydrinate 40 mg in combination with vestibular rehabilitation has shown high efficacy in the treatment of vertigo.

About the Authors

A. S. Lepkov
I.M. Sechenov First Moscow State Medical University, Ministry of Health of Russia (Sechenov University)
Russian Federation

11, Rossolimo St., Build. 1, Moscow 119021


Competing Interests:

There are no conflicts of interes



L M. Antonenko
I.M. Sechenov First Moscow State Medical University, Ministry of Health of Russia (Sechenov University)
Russian Federation

Lyudmila Mikhailovna Antonenko - Department of Nervous Diseases and Neurosurgery, N.V. Sklifosovsky Institute of Clinical Medicine.

11, Rossolimo St., Build. 1, Moscow 119021


Competing Interests:

There are no conflicts of interest



References

1. Antonenko LM. Acute vestibular vertigo: modern methods for diagnosis and treatment. Meditsinskiy sovet = Medical Council. 2023;(10):73-9. doi: 10.21518/ms2023-214 (In Russ.)].

2. Zwergal A, Dieterich M. Vertigo and dizziness in the emergency room. Curr Opin Neurol. 2020;33(1):117-25. doi: 10.1097/WCO.0000000000000769

3. Tarnutzer AA, Koohi N, Lee SU, Kaski D. Diagnostic Errors in the Acutely Dizzy Patient-Lessons Learned. Brain Sci. 2025 Jan 9;15(1):55. doi: 10.3390/brainsci15010055

4. Zhiznevskiy DV, Zamergrad MV, Grachev SP. Modern concepts of vascular vertigo. Nevrologiya, neiropsikhiatriya, psikhosomatika = Neurology, Neuropsychiatry, Psychosomatics. 2023;15(4):4-11. doi: 10.14412/2074-2711-2023-4-4-11 (In Russ.).

5. Toplu ACO, Aslan IK, Akoglu EU, Ozturk TC. The role of the HINTS exam, TriAGe+ score, and ABCD2 score in predicting stroke in acute vertigo patients in the ED. Am J Emerg Med. 2025;91:110-7. doi: 10.1016/j.ajem.2025.02.027

6. Edlow JA, Carpenter C, Akhter M, et al. Guidelines for reasonable and appropriate care in the emergency department 3 (GRACE-3): Acute dizziness and vertigo in the emergency department. Acad Emerg Med. 2023;30(5):442-86. doi: 10.1111/acem.14728

7. Parfenov VA, Antonenko LM, Silina EV. Benign paroxysmal positional vertigo. Nevrologiya, neiropsikhiatriya, psikhosomatika = Neurology, Neuropsychiatry, Psychosomatics. 2023;15(2S):1-10. doi: 10.14412/2074-2711-2023-2S-1-10 (In Russ.).

8. Zastenskaya EN, Antonenko LM. Comorbid disorders and therapy of persistent postural perceptual dizziness. Nevrologiya, neiropsikhiatriya, psikhosomatika = Neurology, Neuropsychiatry, Psychosomatics. 2023;15(4):66-73. doi: 10.14412/2074-2711-2023-466-73 (In Russ.).

9. Parfenov VA, Zamergrad MV, Zaitseva OV, et al. Benign paroxysmal positional vertigo: diagnosis, treatment, rehabilitation. Current concepts on the role of betahistine in the complex treatment of patients with benign paroxysmal positional vertigo. Nevrologiya, neiropsikhiatriya, psikhosomatika = Neurology, Neuropsychiatry, Psychosomatics. 2024;16(5):120-30. doi: 10.14412/2074-2711-2024-5-120-130 (In Russ.).

10. Von Brevern M, Bertholon P, Brandt T, et al. Benign paroxysmal positional vertigo: diagnostic criteria. J Vestib Res. 2015;25(34):105-17. doi: 10.3233/VES-150553

11. Parfenov VA, Zamergrad MV, Melnikov OA. Vertigo: diagnosis and treatment, common diagnostic mistakes. Мoscow; 2019. 208 p. (In Russ.)].

12. Lopez-Escamez JA, Carey J, Chung WH, et al. Diagnostic criteria for Meniere's disease. J Vestibul Res. 2015 Jan 1;25(1):1-7. doi: 10.3233/VES-150549

13. Kosivtsova OV, Starchina YuA. Meniere's disease in the practice of a neurologist. Nevrologiya, neiropsikhiatriya, psikhosomatika = Neurology, Neuropsychiatry, Psychosomatics. 2023;15(1):103-9. doi: 10.14412/2074-2711-2023-1-103-109 (In Russ.).

14. Liqun Z, Park KH, Kim HJ, et al. Acute Unilateral Audio vestibulopathy due to Embolic Labyrinthine Infarction. Front Neurol. 2018 May 2;9:311. doi: 10.3389/fneur.2018.00311

15. Kim TY, Park DW, Lee YJ, et al. Comparison of Inner Ear Contrast Enhancement among Patients with Unilateral Inner Ear Symptoms in MR Images Obtained 10 Minutes and 4 Hours after Gadolinium Injection. AJNR Am J Neuroradiol. 2015 Dec;36(12):2367-72. doi: 10.3174/ajnr.A4439

16. Monak AA, Kaileva NA, Kulesh AA, et al. Labyrinthine infarction as a cause of acute cochleovestibular syndrome. Nevrologiya, neiropsikhiatriya, psikhosomatika = Neurology, Neuropsychiatry, Psychosomatics. 2023;15(1):71-6. doi: 10.14412/2074-2711-2023-1-71-76 (In Russ.)].

17. Kosivtsova OV, Starchina YuA, Urtenov KA, Belkina VV. Dizziness in elderly patients: discussion based on a clinical observation. Nevrologiya, neiropsikhiatriya, psikhosomatika = Neurology, Neuropsychiatry, Psychosomatics. 2024;16(4):85-9. doi: 10.14412/2074-2711-2024-4-85-89 (In Russ.).

18. Pal'chun VT, Makoeva AA, Guseva AL. Dizziness and vertigo associated with vestibular neuronitis: the approaches to the diagnostics and treatment. Vestnik otorinolaringologii = Russian Bulletin of Otorhinolaryngology. 2018;83(3):4-10. doi: 10.17116/otorino20188334 (In Russ.).

19. Calic Z, Nham B, Bradshaw AP, et al. Separating posterior-circulation stroke from vestibular neuritis with quantitative vestibular testing. Clin Neurophysiol. 2020;131(8):2047-55. doi: 10.1016/j.clinph.2020.04.173

20. Adamec I, Krbot SM, Handzic J, Habek M. Incidence, seasonality and comorbidity in vestibular neuritis. Neurol Sci. 2015;36:91-5. doi: 10.1007/s10072014-1912-4

21. Viola P, Gioacchini FM, Astorina A, et al. The pharmacological treatment of acute vestibular syndrome. Front Neurol. 2022 Sep 9;13:999112. doi: 10.3389/fneur.2022.999112

22. Strupp M, Magnusson M. Acute unilateral vestibulopathy. Neurol Clin. 2015;33:669-85. doi: 10.1016/j.ncl.2015.04.012

23. Lee SH, Park SH, Kim JS, et al. Isolated unilateral infarction of the cerebellar tonsil: ocular motor findings. Ann Neurol. 2014 Mar;75(3):429-34. doi: 10.1002/ana.24094

24. Yacovino DA, Ally MP, Luis L, Zee DS. The Floccular Syndrome: Dynamic Changesin Eye Movements and Vestibulo-ocular Reflex in Isolated Infarction of the Cerebellar Flocculus. Cerebellum. 2018 Apr;17(2):122-31. doi: 10.1007/s12311-0170878-1

25. Saber Tehrani AS, Kattah JC, Kerber KA, et al. Diagnosing stroke in acute dizziness and vertigo: pitfalls and pearls. Stroke. 2018;49:788-95. doi: 10.1161/STROKEAHA.117.016979

26. Shah VP, Oliveira J E Silva L, Farah W, et al. Diagnostic accuracy of the physical examination in emergency department patients with acute vertigo or dizziness: A systematic review and meta-analysis for GRACE-3. Acad Emerg Med. 2023;30(5):552-78. doi: 10.1111/acem.14630

27. Tarnutzer AA, Edlow JA. Bedside Testing in Acute Vestibular Syndrome-Evaluating HINTS Plus and Beyond – A Critical Review. Audiol Res. 2023 Sep 1;13(5):670-85. doi: 10.3390/audiolres13050059

28. Krishnan K, Bassilious K, Eriksen E, et al. Posterior circulation stroke diagnosis using HINTS in patients presenting with acute vestibular syndrome: A systematic review. Eur Stroke J. 2019;4(3):233-9. doi: 10.1177/239698731984370

29. Lempert T, von Brevern M. Vestibular Migraine. Neurol Clin. 2019;37(4):695-706. doi: 10.1016/J.NCL.2019.06.003

30. Ayzenberg I, Katsarava Z, Sborowski A, et al. Lifting the Burden. The prevalence of primary headache disorders in Russia: a countrywide survey. Cephalalgia. 2012;32(5):373-81. doi: 10.1177/0333102412438977

31. Klimentova DA, Tabeeva GR. Migraine in perimenopausal women. Nevrologiya, neiropsikhiatriya, psikhosomatika = Neurology, Neuropsychiatry, Psychosomatics. 2023;15(5):102-8. doi: 10.14412/2074-2711-2023-5-102-108 (In Russ.).

32. Tabeeva GR, Kosivtsova OV, Kovalchuk NA, Orlyuk TA. Refractory migraine. Nevrologiya, neiropsikhiatriya, psikhosomatika = Neurology, Neuropsychiatry, Psychosomatics. 2024;16(2):76-86. doi: 10.14412/2074-2711-2024-2-76-86 (In Russ.)].

33. Zastenskaia EN, Antonenko LM. Chronic dizziness: modern treatment methods taking into account comorbidity. Nevrologiya, neiropsikhiatriya, psikhosomatika = Neurology, Neuropsychiatry, Psychosomatics. 2023;15(6):71-7. doi: 10.14412/2074-2711-2023-6-71-77 (In Russ.)].

34. Kerber KA, Brown DL, Lisabeth LD, et al. Stroke among patients with dizziness, vertigo, and imbalance in the emergency department: a population-based study. Stroke. 2006; 37: 2484-7. doi: 10.1161/01.str.0000240329.48263.0d

35. Garcia-Munoz C, Cortes-Vega MD, Heredia-Rizo AM, et al. Effectiveness of Vestibular Training for Balance and Dizziness Rehabilitation in People with Multiple Sclerosis: A Systematic Review and MetaAnalysis. J Clin Med. 2020 Feb 21;9(2):590. doi: 10.3390/jcm9020590

36. Nabiev SR, Dzhukkaeva SA, Asvedov MS, Voskresenskaya ON. The central vein sign in the diagnosis of multiple sclerosis. Nevrologiya, neiropsikhiatriya, psikhosomatika = Neurology, Neuropsychiatry, Psychosomatics. 2024;16(2):14-8. doi: 10.14412/2074-2711-2024-2-14-18 (In Russ.).

37. Nabiev SR, Dzhukkaeva SA, Asvedov MS, et al. Concentration of immunoglobulin free light chains in cerebrospinal fluid in the diagnosis of multiple sclerosis. Nevrologiya, neiropsikhiatriya, psikhosomatika = Neurology, Neuropsychiatry, Psychosomatics. 2024;16(3):26-30. doi: 10.14412/2074-2711-2024-3-26-30 (In Russ.)].

38. Scholtz AW, Hahn A, Stefflova B, et al. Efficacy and Safety of a Fixed Combination of Cinnarizine 20 mg and Dimenhydrinate 40 mg vs Betahistine Dihydrochloride 16 mg in Patients with Peripheral Vestibular Vertigo: A Prospective, Multinational, Multicenter, Double-Blind, Randomized, Non-inferiority Clinical Trial. Clin Drug Investig. 2019;39:1045-56. doi: 10.1007/s40261-019-00858-6

39. Bedenko AS, Antonenko LM. Vitamin D and homocysteine in benign paroxysmal positional vertigo. Meditsinskiy sovet = Medical Council. 2022;(2):63-9. doi: 10.21518/2079701X-2022-16-2-63-69 (In Russ.).

40. Parfenov V, Golyk V, Matsnev E, et al. Effectiveness of betahistine (48 mg/day) in patients with vestibular vertigo during routine practice: The VIRTUOSO study. PLoS One. 2017;12(3):e0174114. doi: 10.1371/journal.pone.0174114

41. Novotny M, Kostrica R. Fixed combination of cinnarizine and dimenhydrinate versus betahistine dimesylate in the treatment of Meniere's disease: a randomized, doubleblind, parallel-group clinical study. Int Tinnitus J. 2002;8:115-23.

42. Novotny M, Bognar-Steinberg I, Baumann W. Fixed combination of cinnarizine and dimenhydrinate versus betahistine dimesylate in the treatment of Meniere's disease: post hoc non-inferiority analysis of a prospective, randomized, double-blind study. Arch Sensol Neurootol ASN. 2011;6. Available at: https://neurootology.org/archives/649

43. Ivanova GE, Kunelskaya NL, Parfenov VA, et al. Vestibular rehabilitation in complex therapy of vestibular vertigo (consensus of experts). Nevrologiya, neiropsikhiatriya, psikhosomatika = Neurology, Neuropsychiatry, Psychosomatics. 2024;16(1):114-21. doi: 10.14412/2074-2711-2024-1-114-121 (In Russ.)].

44. Vasquez-Codina AY, Leguizamo-Isaza JM, Aborashed-Amador NF, et al. Acute basilar artery occlusion (BAO): a pictorial review of multimodal imaging findings. Emerg Radiol. 2021;28(6):1205-12. doi: 10.1007/s10140-021-01965-8


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For citations:


Lepkov AS, Antonenko LM. Diagnosis and treatment of acute vertigo in emergency neurological practice. Nevrologiya, neiropsikhiatriya, psikhosomatika = Neurology, Neuropsychiatry, Psychosomatics. 2025;17(4):134-140. (In Russ.) https://doi.org/10.14412/2074-2711-2025-4-134-140

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ISSN 2074-2711 (Print)
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