Efficacy and tolerance of intravenous lacosamide in urgent neurological situations
Abstract
The authors analyze the efficacy of intravenous lacosamide (LCSM) in combined therapy for partial epilepsy. The data available in the literature and their 2 observations suggest that intravenous LCSM is promising when its oral use is impossible, including in therapy for status epilepticus/series of partial seizures.
About the Authors
P. N. Vlasov
Department of Nervous Diseases, Therapeutic Faculty, Moscow State University of Medicine and Dentistry
Russian Federation
Russian Federation
E. G. Kamelkova
Department of Nervous Diseases, Therapeutic Faculty, Moscow State University of Medicine and Dentistry
Russian Federation
Russian Federation
F. R. Drozzhina
Department of Nervous Diseases, Therapeutic Faculty, Moscow State University of Medicine and Dentistry
Russian Federation
Russian Federation
References
1. <div><p>Карлов В.А. Эпилепсия у детей и взрослых женщин и мужчин: Рук-во для врачей. М.: Медицина, 2010;483–511.</p><p>Errington A., Stohr T., Heers C. et al. The investigational anticonvulsant lacosamide selectively enhances slow inactivation of voltage-gated sodium channels. Mol Pharmacol 2008;73:157–69.</p><p>Freitag J.M., Beyreuther B., Heers C. et al. Lacosamide modulates collapsin response mediator protein 2 (CRMP-2). Epilepsia 2007;48:320.</p><p>Cross S.A., Curran M.P. Lacosamide in partial-onset seizures. Drugs 2009;69(4):449–59.</p><p>Biton V., Rosenfeld W.E., Whitesides J. et al. Intravenous lacosamide as replacement for oral lacosamide in patients with partial-onset seizures. Epilepsia 2008;49(3):418–24.</p><p>Krauss G., Ben-Menachem E., Mameniskiene R. et al. Intravenous lacosamide as short-term replacement for oral lacosamide in partial-onset seizures Epilepsia 2010;51(6):951–7.</p><p>Fountain N.B., Krauss G., Isojarvi J. et al. A multiceter, open-label trial to assess the safety and tolerability of a single intravenous loading dose of lacosamide followed by oral maintenance as adjunctive therapy in patients with partial-onset seizures. Epilepsia 2010;51(Suppl. 4):123.</p><p>Unterberger I., Hoefler J., Walser G. et al. Safety and efficacy of IV Lacosamide in status epilepticus and seizure cluster. The 3rd London-Innsbruck colloquium on acute seizures and status epilepticus. Abstr 2011;P45.</p><p>Sake J.-K.; Hebert D., Isojärvi J. et al. A pooled analysis of Lacosamide clinical trial data grouped by mechanism of action of concomitant antiepileptic drugs. CNS Drugs 2010;24(12):1055–68.</p></div><br />
Review
For citations:
Vlasov P.N., Kamelkova E.G., Drozzhina F.R. Efficacy and tolerance of intravenous lacosamide in urgent neurological situations. Neurology, Neuropsychiatry, Psychosomatics. 2012;4(1S):60-63. (In Russ.) https://doi.org/10.14412/2074-2711-2012-2501
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