nnpNeurology, Neuropsychiatry, PsychosomaticsНеврология, нейропсихиатрия, психосоматика2074-27112310-1342"IMA-Press", LLC10.14412/2074-2711-2012-2501nnp-232Research ArticleArticlesСтатьиEfficacy and tolerance of intravenous lacosamide in urgent neurological situationsЭффективность и переносимость лакосамида для внутривенного введения при ургентных неврологических ситуацияхВласовП. Н.VlasovP. N.vpn_neuro@mail.ruКамельковаЕ. Г.KamelkovaE. G.vpn_neuro@mail.ruДрожжинаГ. Р.DrozzhinaF. R.vpn_neuro@mail.ruКафедра нервных болезней лечебного факультета МГМСУ, МоскваРоссияDepartment of Nervous Diseases, Therapeutic Faculty, Moscow State University of Medicine and DentistryRussian Federation20123003201241SSpecial issue "Epilepsy"6063Copyright © Vlasov P.N., Kamelkova E.G., Drozzhina F.R., 20142014Власов П.Н., Камелькова Е.Г., Дрожжина Г.Р.Vlasov P.N., Kamelkova E.G., Drozzhina F.R.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://nnp.ima-press.net/nnp/article/view/232

The authors analyze the efficacy of intravenous lacosamide (LCSM) in combined therapy for partial epilepsy. The data available in the literature and their 2 observations suggest that intravenous LCSM is promising when its oral use is impossible, including in therapy for status epilepticus/series of partial seizures.

Анализируется эффективность внутривенной формы лакосамида (ЛКСМ) в комбинированной терапии парциальной эпилепсии. Данные литературы и 2 собственных наблюдений свидетельствуют о перспективности внутривенного применения ЛКСМ в ситуациях, когда пероральное его использование невозможно, в том числе в терапии статуса/серии парциальных припадков.

эпилептический статуспарциальные эпилептические припадки у взрослыхлакосамидэффективностьпереносимостьstatus epilepticuspartial epileptic seizures in adultslacosamideefficacytoleranceReferences<div><p>Карлов В.А. Эпилепсия у детей и взрослых женщин и мужчин: Рук-во для врачей. М.: Медицина, 2010;483–511.</p><p>Errington A., Stohr T., Heers C. et al. The investigational anticonvulsant lacosamide selectively enhances slow inactivation of voltage-gated sodium channels. Mol Pharmacol 2008;73:157–69.</p><p>Freitag J.M., Beyreuther B., Heers C. et al. Lacosamide modulates collapsin response mediator protein 2 (CRMP-2). Epilepsia 2007;48:320.</p><p>Cross S.A., Curran M.P. Lacosamide in partial-onset seizures. Drugs 2009;69(4):449–59.</p><p>Biton V., Rosenfeld W.E., Whitesides J. et al. Intravenous lacosamide as replacement for oral lacosamide in patients with partial-onset seizures. Epilepsia 2008;49(3):418–24.</p><p>Krauss G., Ben-Menachem E., Mameniskiene R. et al. Intravenous lacosamide as short-term replacement for oral lacosamide in partial-onset seizures Epilepsia 2010;51(6):951–7.</p><p>Fountain N.B., Krauss G., Isojarvi J. et al. A multiceter, open-label trial to assess the safety and tolerability of a single intravenous loading dose of lacosamide followed by oral maintenance as adjunctive therapy in patients with partial-onset seizures. Epilepsia 2010;51(Suppl. 4):123.</p><p>Unterberger I., Hoefler J., Walser G. et al. Safety and efficacy of IV Lacosamide in status epilepticus and seizure cluster. The 3rd London-Innsbruck colloquium on acute seizures and status epilepticus. Abstr 2011;P45.</p><p>Sake J.-K.; Hebert D., Isojärvi J. et al. A pooled analysis of Lacosamide clinical trial data grouped by mechanism of action of concomitant antiepileptic drugs. CNS Drugs 2010;24(12):1055–68.</p></div><br /><div><p>Карлов В.А. Эпилепсия у детей и взрослых женщин и мужчин: Рук-во для врачей. М.: Медицина, 2010;483–511.</p><p>Errington A., Stohr T., Heers C. et al. The investigational anticonvulsant lacosamide selectively enhances slow inactivation of voltage-gated sodium channels. Mol Pharmacol 2008;73:157–69.</p><p>Freitag J.M., Beyreuther B., Heers C. et al. Lacosamide modulates collapsin response mediator protein 2 (CRMP-2). Epilepsia 2007;48:320.</p><p>Cross S.A., Curran M.P. Lacosamide in partial-onset seizures. Drugs 2009;69(4):449–59.</p><p>Biton V., Rosenfeld W.E., Whitesides J. et al. Intravenous lacosamide as replacement for oral lacosamide in patients with partial-onset seizures. Epilepsia 2008;49(3):418–24.</p><p>Krauss G., Ben-Menachem E., Mameniskiene R. et al. Intravenous lacosamide as short-term replacement for oral lacosamide in partial-onset seizures Epilepsia 2010;51(6):951–7.</p><p>Fountain N.B., Krauss G., Isojarvi J. et al. A multiceter, open-label trial to assess the safety and tolerability of a single intravenous loading dose of lacosamide followed by oral maintenance as adjunctive therapy in patients with partial-onset seizures. Epilepsia 2010;51(Suppl. 4):123.</p><p>Unterberger I., Hoefler J., Walser G. et al. Safety and efficacy of IV Lacosamide in status epilepticus and seizure cluster. The 3rd London-Innsbruck colloquium on acute seizures and status epilepticus. Abstr 2011;P45.</p><p>Sake J.-K.; Hebert D., Isojärvi J. et al. A pooled analysis of Lacosamide clinical trial data grouped by mechanism of action of concomitant antiepileptic drugs. CNS Drugs 2010;24(12):1055–68.</p></div><br />

The authors declare that there are no conflicts of interest present.