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Hormone-dependent abnormality of the female sexual sphere during monotherapy with valproate, carbamazepine, and lamotrigine

https://doi.org/10.14412/2074-2711-2012-2496

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Abstract

Hormonal function of the ovary was analyzed in 95 childbearing-age (18—30-year-old) epileptic patients receiving monotherapy with antiepileptic drugs (AEDs) for at least a year. Of them, 40, 40, and 15 patients had monotherapy with valproic acid, carbamazepine, or lamotrigine, respectively. Fifty-two (54.7%) patients with epilepsy were observed to have ovarian hormonal dysfunctions characterized by lower progesterone levels and higher luteinizing hormone and testosterone concentrations in both the follicular and luteinic phase of a menstrual cycle. The magnitude of hormonal changes depended on the specific features of epilepsy: duration, form, site of an epileptogenic focus. The use of various AEDs had an insignificant impact on the rate and pattern of hormonal abnormalities.

About the Authors

P. N. Vlasov
Department of Nervous Diseases, Therapeutic Faculty, Moscow State University of Medicine and Dentistry
Russian Federation


O. F. Serova
Department of Nervous Diseases, Therapeutic Faculty, Moscow State University of Medicine and Dentistry
Russian Federation


D. V. Dranko
Department of Nervous Diseases, Therapeutic Faculty, Moscow State University of Medicine and Dentistry
Russian Federation


N. V. Filatova
Department of Nervous Diseases, Therapeutic Faculty, Moscow State University of Medicine and Dentistry
Russian Federation


Z. S. Shakhabasova
Department of Nervous Diseases, Therapeutic Faculty, Moscow State University of Medicine and Dentistry
Russian Federation


References

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For citation:


Vlasov P.N., Serova O.F., Dranko D.V., Filatova N.V., Shakhabasova Z.S. Hormone-dependent abnormality of the female sexual sphere during monotherapy with valproate, carbamazepine, and lamotrigine. Neurology, Neuropsychiatry, Psychosomatics. 2012;4(1S):34-38. (In Russ.) https://doi.org/10.14412/2074-2711-2012-2496

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ISSN 2074-2711 (Print)
ISSN 2310-1342 (Online)