Hormone-dependent abnormality of the female sexual sphere during monotherapy with valproate, carbamazepine, and lamotrigine
Abstract
Hormonal function of the ovary was analyzed in 95 childbearing-age (18—30-year-old) epileptic patients receiving monotherapy with antiepileptic drugs (AEDs) for at least a year. Of them, 40, 40, and 15 patients had monotherapy with valproic acid, carbamazepine, or lamotrigine, respectively. Fifty-two (54.7%) patients with epilepsy were observed to have ovarian hormonal dysfunctions characterized by lower progesterone levels and higher luteinizing hormone and testosterone concentrations in both the follicular and luteinic phase of a menstrual cycle. The magnitude of hormonal changes depended on the specific features of epilepsy: duration, form, site of an epileptogenic focus. The use of various AEDs had an insignificant impact on the rate and pattern of hormonal abnormalities.
About the Authors
P. N. Vlasov
Department of Nervous Diseases, Therapeutic Faculty, Moscow State University of Medicine and Dentistry
Russian Federation
Russian Federation
O. F. Serova
Department of Nervous Diseases, Therapeutic Faculty, Moscow State University of Medicine and Dentistry
Russian Federation
Russian Federation
D. V. Dranko
Department of Nervous Diseases, Therapeutic Faculty, Moscow State University of Medicine and Dentistry
Russian Federation
Russian Federation
N. V. Filatova
Department of Nervous Diseases, Therapeutic Faculty, Moscow State University of Medicine and Dentistry
Russian Federation
Russian Federation
Z. S. Shakhabasova
Department of Nervous Diseases, Therapeutic Faculty, Moscow State University of Medicine and Dentistry
Russian Federation
Russian Federation
References
1. <div><p>Карлов В.А. Эпилепсия у детей и взрослых женщин и мужчин. Рук-во для врачей. М.: Медицина, 2010;718.</p><p>Власов П.Н., Карлов В.А., Кушлинский Н.Е. Фармако-гормональные взаимоотношения при применении карбамазепина и вальпроевой кислоты у больных эпилепсией женщин детородного возраста. Журн невропатол и психиатр 2001;11:26–30.</p><p>Bauer J., Jarre A., Klingmiller D. et al. Polycystic ovary syndrome in patients with focal epilepsy: a study in 93 women. Epilepsy Res 2000;41:163–7.</p><p>Morrell M.J. Reproductive and metabolic disorders in women with epilepsy. Epilepsia 2003;44(Suppl. 4):11–20.</p><p>Morrell M.J., Hayes F.J., Sluss P.M. et al. Hyperandrogenism, ovulatory dysfunction, and polycystic ovary syndrome with valproate versus lamotrigine. Ann Neurol 2008;2:200–11.</p><p>Краснопольский В.И., Логутова Л.С., Серова О.Ф. и др. Синдром поликистозных яичников (информационно-методическое письмо). М., 2005;40.</p><p>Власов П.Н., Юдаев В.Н. и др. Особенности эпилепсии у женщин с нарушением менструальной функции. Журн неврол и психиатр 2011;5:26–30.</p><p>Isojärvi J.I., Laatikainen T.J., Pakarinen A.J. et al. Polycystic ovaries and hyperandrogenism in women taking valproate for epilepsy. N Engl J Med 1993;19:1383–8.</p><p>Betts Т., Yarrow Н., Dutton N. et al. A study of anticonvusant medication on ovarian function in a group of women with epilepsy who have only ever taken on anticonvulsant compared with a group of women without epilepsy. Seizure 2003;12:323–9.</p><p>Murialdo G., Galimberti C.A. Effects of valproate, phenobarbital, and carbamazepine on sex steroid setup in women with epilepsy. Clin Neuropharmacol 1998;1:52–8.</p><p>De Vries L., Karasik A., Landau Z. et al. Endocrine effect of valproate in adolescent girls with epilepsy. Epilepsia 2007;48:470–7.</p><p>Жидкова И.А. Влияние эпилепсии и антиэпилептической терапии на репродуктивное здоровье женщины. Автореф. дисс. … докт. мед. наук. М., 2010;48.</p><p>Herzog A.G., Seibel M.M., Schomer D.L. et al. Reproductive endocrine disorders in women with partial seizures of temporal lobe origin. Arch Neurol 1986;4:341–6.</p><p>Silveira D.C., Klein P., Ransil B.J. et al. Lateral asymmetry in activation of hypothalamic neurons with unilateral amygdaloid seizures. Epilepsia 2000;41:34–41.</p><p>The Rotterdam ESHRE/ASRM-sponsored PCOS consensus workshop group. Revised 2003 consensus jn diagnostic criteria and long-term health risk related to polycystic ovary syndrome (PCOS). Hum Reprod 2005;19:1–7.</p></div><br />
For citation:
Vlasov P.N., Serova O.F., Dranko D.V., Filatova N.V., Shakhabasova Z.S. Hormone-dependent abnormality of the female sexual sphere during monotherapy with valproate, carbamazepine, and lamotrigine. Neurology, Neuropsychiatry, Psychosomatics. 2012;4(1S):34-38. (In Russ.) https://doi.org/10.14412/2074-2711-2012-2496
Views: 415
Email this article 