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On the antitumour effects of B vitamins

https://doi.org/10.14412/2074-2711-2024-1-102-113

Abstract

In periodicals, vitamins and vitamin-mineral complexes (VMCs) are “accused” of having allegedly carcinogenic effects. The results of a systematic review of the literature on B vitamins presented in this paper clearly show that vitamins have at least no influence on tumour risk. When analysing experimental and clinical data on this topic, particular attention should be paid to the dosage of vitamins in monotherapy and when used as part of a VMCs.

About the Authors

O. A. Gromova
Federal Research Center “Computer Science and Management”, Russian Academy of Sciences
Russian Federation

44, Vavilovа St., Build. 2, Moscow 119333


Competing Interests:

This work was supported by the grant of the Russian Science Foundation No. 20-12-00175-p on the base of Ivanovo State University of Chemistry and Technology. The authors are solely responsible for submitting the final version of the manuscript for publication. All the authors have participated in developing the concept of the article and in writing the manuscript. The final version of the manuscript has been approved by all the authors.



I. Yu. Torshin
Federal Research Center “Computer Science and Management”, Russian Academy of Sciences
Russian Federation

44, Vavilovа St., Build. 2, Moscow 119333


Competing Interests:

This work was supported by the grant of the Russian Science Foundation No. 20-12-00175-p on the base of Ivanovo State University of Chemistry and Technology. The authors are solely responsible for submitting the final version of the manuscript for publication. All the authors have participated in developing the concept of the article and in writing the manuscript. The final version of the manuscript has been approved by all the authors.



M. V. Filimonova
Medical Radiological Research Center named after. A.F. Tsyb, brunch of National Medical Research Radiology Centre, Ministry of Health of Russia
Russian Federation

4, Koroleva St., Obninsk, 249036


Competing Interests:

This work was supported by the grant of the Russian Science Foundation No. 20-12-00175-p on the base of Ivanovo State University of Chemistry and Technology. The authors are solely responsible for submitting the final version of the manuscript for publication. All the authors have participated in developing the concept of the article and in writing the manuscript. The final version of the manuscript has been approved by all the authors.



D. E. Frolova
Federal Research Center “Computer Science and Management”, Russian Academy of Sciences; Ivanovo State Medical Academy, Ministry of Health of Russia
Russian Federation

44, Vavilovа St., Build. 2, Moscow 119333;
8, SheremetevskyProsp., Ivanovo 153012


Competing Interests:

This work was supported by the grant of the Russian Science Foundation No. 20-12-00175-p on the base of Ivanovo State University of Chemistry and Technology. The authors are solely responsible for submitting the final version of the manuscript for publication. All the authors have participated in developing the concept of the article and in writing the manuscript. The final version of the manuscript has been approved by all the authors.



References

1. Torshin IYu (Ed.Gromova OA). Sensing the change from molecular genetics to personalized medicine. NY, USA: Nova Biomedical Books; 2009. In “Bioinformatics in the PostGenomic Era” series. ISBN 1-60692-217-0

2. Gromova OA, Torshin IYu. Molecular mechanisms of synergistic analgesic and neuroprotective action of B group vitamins according to the results of proteomic analysis. Nevrologiya, neiropsikhiatriya, psikhosomatika = Neurology, Neuropsychiatry, Psychosomatics. 2023;15(3):128-38. doi: 10.14412/2074-2711-2023-3-128-138 (In Russ.).

3. Gromova OA, Limanova OA, Torshin IYu, et al. The dose-dependence of the protective effects of folic acid in pre-conception care and during pregnancy and lactation. Russkiy meditsinskiy zhurnal = Russian Medical Journal. 2014;22(1):27-34 (In Russ.).

4. Hernandez BY, McDuffie K, Wilkens LR, et al. Diet and premalignant lesions of the cervix: evidence of a protective role for folate, riboflavin, thiamin, and vitamin B12. Cancer Causes Control. 2003 Nov;14(9):859-70. doi: 10.1023/b:caco.0000003841.54413.98

5. Wu K, Helzlsouer KJ, Comstock GW, et al. A prospective study on folate, B12, and pyridoxal 5'-phosphate (B6) and breast cancer. Cancer Epidemiol Biomarkers Prev. 1999 Mar;8(3):209-17.

6. Nakagawa K, Kudoh S, Matsui K, et al. A phase I study of pemetrexed (LY231514) supplemented with folate and vitamin B12 in Japanese patients with solid tumours. Br J Cancer. 2006 Sep 18;95(6):677-82. doi: 10.1038/sj.bjc.6603321. Epub 2006 Aug 29.

7. Lajous M, Lazcano-Ponce E, Hernandez-Avila M, et al. Folate, vitamin B(6), and vitamin B(12) intake and the risk of breast cancer among Mexican women. Cancer Epidemiol Biomarkers Prev. 2006 Mar;15(3):443-8. doi: 10.1158/1055-9965.EPI-05-0532

8. Greenop KR, Miller M, Bailey HD, et al. Childhood folate, B6, B12, and food group intake and the risk of childhood brain tumors: results from an Australian case-control study. Cancer Causes Control. 2015 Jun;26(6):871-9. doi: 10.1007/s10552-015-0562-z. Epub 2015 Mar 20.

9. Liu Y, Yu Q, Zhu Z, et al. Vitamin and multiple-vitamin supplement intake and incidence of colorectal cancer: a meta-analysis of cohort studies. Med Oncol. 2015 Jan;32(1):434. doi: 10.1007/s12032-014-0434-5. Epub 2014 Dec 10.

10. Arendt JF, Pedersen L, Nexo E, Sorensen HT. Elevated plasma vitamin B12 levels as a marker for cancer: a populationbased cohort study. J Natl Cancer Inst. 2013 Dec 4;105(23):1799-805. doi: 10.1093/jnci/djt315. Epub 2013 Nov 18.

11. Arendt JF, Farkas DK, Pedersen L, et al. Elevated plasma vitamin B12 levels and cancer prognosis: A population-based cohort study. Cancer Epidemiol. 2016 Feb;40:158-65. doi: 10.1016/j.canep.2015.12.007. Epub 2015 Dec 24.

12. Obeid R. High Plasma Vitamin B12 and Cancer in Human Studies: A Scoping Review to Judge Causality and Alternative Explanations. Nutrients. 2022 Oct 25;14(21):4476. doi: 10.3390/nu14214476

13. Torshin IYu, Rudakov KV. On metric spaces arising during formalization of problems of recognition and classification. Part 1: properties of compactness. Pattern Recognition and Image Analysis (Advances in Mathematical Theory and Applications). 2016;26(2):274-84. doi: 10.1134/S1054661816020255

14. Torshin IYu, Rudakov KV. On metric spaces arising during formalization of problems of recognition and classification. Part 2: density properties. Pattern Recognition and Image Analysis (Advances in Mathematical Theory and Applications). 2016;26(3):483-96. doi: 10.1134/S1054661816030202

15. Torshin IYu, Gromova OA, Maiorova LA. The Prospects for the use of vitamin B12 derivatives in pharmacology. FARMAKOEKONOMIKA. Sovremennaya farmakoekonomika i farmakoepidemiologiya = FARMAKOEKONOMIKA. Modern Pharmacoeconomics and Pharmacoepidemiology. 2023;16(3):434-44. doi: 10.17749/2070-4909/farmakoekonomika.2023.198.434.444 (In Russ.).

16. Torshin IYu, Filimonova MV, Gromova OA, et al. Chemoreactome screening of aquacobalamin and heptamethyl ester of cyanoaquacobyrinic acid cytotoxic effects on tumor cells with experimental confirmation on BT-474 and A549 cell lines. FARMAKOEKONOMIKA. Sovremennaya farmakoekonomika i farmakoepidemiologiya = FARMAKOEKONOMIKA. Modern Pharmacoeconomics and Pharmacoepidemiology. doi: 10.17749/2070-4909/farmakoekonomika.2023.209. Available at: https://www.pharmacoeconomics.ru/jour/article/view/921/503 (In Russ.).

17. Byerly S, Parreco JP, Soe-Lin H, et al. Vitamin C and thiamine are associated with lower mortality in sepsis. J Trauma Acute Care Surg. 2020 Jul;89(1):111-7. doi: 10.1097/TA.0000000000002613

18. Assouline B, Faivre A, Verissimo T, et al. Thiamine, Ascorbic Acid, and Hydrocortisone As a Metabolic Resuscitation Cocktail in Sepsis: A Meta-Analysis of 19 Randomized Controlled Trials With Trial Sequential Analysis. Crit Care Med. 2021 Dec 1;49(12):2112-20. doi: 10.1097/CCM.0000000000005262

19. Iimura Y, Kurokawa T, Andoh S, et al. Association between thiamine decrease and neuropsychiatric symptoms in gastrointestinal and hematological cancer patients receiving chemotherapy. Biomed Pharmacother. 2021 Sep;141:111929. doi: 10.1016/j.biopha.2021.111929.

20. Egnell M, Fassier P, Lecuyer L, et al. B-Vitamin Intake from Diet and Supplements and Breast Cancer Risk in Middle-Aged Women: Results from the Prospective NutriNet-Sante Cohort. Nutrients. 2017 May 13;9(5):488. doi: 10.3390/nu9050488

21. Gromova OA, Torshin IYu, Kobalava ZhD, Sorokina MA. About fundamental and clinical aspects of magnesium and ribolavine synergic action in therapeutic practice. Terapiya = Therapy. 2018;19(1):119-31 (In Russ.).

22. Pan F, Chen Y, He JZ, et al. Dietary riboflavin deficiency promotes N-nitrosomethylbenzylamine-induced esophageal tumorigenesis in rats by inducing chronic inflammation. Am J Cancer Res. 2019 Nov 1;9(11):2469-81. eCollection 2019.

23. Liu Y, Yu QY, Zhu ZL, et al. Vitamin B2 intake and the risk of colorectal cancer: a meta-analysis of observational studies. Asian Pac J Cancer Prev. 2015;16(3):909-13. doi: 10.7314/apjcp.2015.16.3.909

24. Gromova OA, Torshin IYu. Systematic analysis of the experimental and clinical pharmacology of nicotinamide and prospects for the treatment of atherosclerosis. Eksperimental'naya i klinicheskaya gastroenterologiya = Experimental and Clinical Gastroenterology. 2022;(10):111-25. doi: 10.31146/1682-8658-ecg-206-10-111-125 (In Russ.).

25. Lohani M, Dhasmana A, Haque S, et al. Niacin deficiency modulates genes involved in cancer: Are smokers at higher risk? J Cell Biochem. 2019 Jan;120(1):232-42. doi: 10.1002/jcb.27324. Epub 2018 Sep 1.

26. Ma JL, Zhao Y, Guo CY, et al. Dietary vitamin B intake and the risk of esophageal cancer: a meta-analysis. Cancer Manag Res. 2018 Nov 5;10:5395-410. doi: 10.2147/CMAR.S168413

27. Gromova OA, Rudakov KV, Torshin IYu. Systematic analysis of the effects of choline on the nervous system based on biochemical pathways. Analysis of independent literature on molecular pharmacology and clinical studies. Trudnyy patsiyent = Difficult Patient. 2009;7(4-5):13-8 (In Russ.).

28. Abratte CM, Wang W, Li R, et al. Folate intake and the MTHFR C677T genotype influence choline status in young Mexican American women. J NutrBiochem. 2008 Mar;19(3):158-65. doi: 10.1016/j.jnutbio.2007.02.004

29. Melse-Boonstra A, Holm PI, Ueland PM, et al. Betaine concentration as a determinant of fasting total homocysteine concentrations and the effect off olic acid supplementation on betaine concentrations. Am J Clin Nutr. 2005 Jun;81(6):1378-82. doi: 10.1093/ajcn/81.6.1378

30. Chiuve SE, Giovannucci EL, Hankinson SE, et al. The association between betaine and choline intakes and the plasma concentrations of homocysteine in women. Am J Clin Nutr. 2007 Oct;86(4):1073-81. doi: 10.1093/ajcn/86.4.1073

31. Han P, Bidulescu A, Barber JR, et al. Dietary choline and betaine intakes and risk of total and lethal prostate cancer in the Atherosclerosis Risk in Communities (ARIC) Study. Cancer Causes Control. 2019 Apr;30(4):343-54. doi: 10.1007/s10552-019-01148-4. Epub 2019 Mar 1.

32. Van Puyvelde H, Dimou N, Katsikari A, et al. The association between dietary intakes of methionine, choline and betaine and breast cancer risk: A systematic review and metaanalysis. Cancer Epidemiol. 2023 Apr;83:102322. doi: 10.1016/j.canep.2023.102322. Epub 2023 Jan 24.

33. Gromova OA, Torshin IYu, Limanova OA, Nikonov AA. Pathophysiology of vegetativevascular paroxysms (hot flashes) in women during menopause and the mechanism of action of beta-alanine. New clinical and pharmacological concept. Ginekologiya = Gynecology. 2010;12(2):29-36 (In Russ.).

34. Hajizadeh B, Jessri M, Akhoondan M, et al. Nutrient patterns and risk of esophageal squamous cell carcinoma: a case-control study. Dis Esophagus. 2012 Jul;25(5):442-8. doi: 10.1111/j.1442-2050.2011.01272.x

35. Shi J, Wang L, Zhang Y, Zhi D. Clinical efficacy of vitamin B in the treatment of mouth ulcer: a systematic review and meta-analysis. Ann Palliat Med. 2021 Jun;10(6):6588-96. doi: 10.21037/apm-21-1064

36. Zhang SM, Cook NR, Albert CM, et al. Effect of combined folic acid, vitamin B6, and vitamin B12 on cancer risk in women: a randomized trial. JAMA. 2008 Nov 5;300(17):2012-21. doi: 10.1001/jama.2008.555

37. Gromova OA, Torshin IYu. Magniyi “boleznitsivilizatsii” [Magnesium and “diseases of civilization”]. Moscow: GEOTAR-Media; 2018. 800 p. ISBN 978-5-9704-4527-3 (In Russ.).

38. Figueiredo JC, Levine AJ, Grau MV, et al. Vitamins B2, B6, and B12 and risk of new colorectal adenomas in a randomized trial of aspirin use and folic acid supplementation. Cancer Epidemiol Biomarkers Prev. 2008 Aug;17(8):2136-45. doi: 10.1158/1055-9965.EPI-07-2895

39. Gylling B, Myte R, Schneede J, et al. Vitamin B-6 and colorectal cancer risk: a prospective population-based study using 3 distinct plasma markers of vitamin B-6 status. Am J Clin Nutr. 2017;105(4):897-904 doi:10.3945/ajcn.116.139337. Epub 2017 Mar 8.

40. Zuo H, Ueland PM, Midttun O, et al. Results from the European Prospective Investigation into Cancer and Nutrition Link Vitamin B6 Catabolism and Lung Cancer Risk. Cancer Res. 2018 Jan 1;78(1):302-8. doi: 10.1158/0008-5472.CAN-17-1923

41. Mocellin S, Briarava M, Pilati P. Vitamin B6 and Cancer Risk: A Field Synopsis and Meta-Analysis. J Natl Cancer Inst. 2017 Mar 1;109(3):1-9. doi: 10.1093/jnci/djw230

42. Waldrop GL, Holden HM, St Maurice M. The enzymes of biotin dependent COВ metabolism: what structures reveal about their reaction mechanisms. Protein Sci. 2012 Nov;21(11):1597-619. doi: 10.1002/pro.2156

43. Gholamalizadeh M, Behrad Nasab M, Ahmadzadeh M, et al. The association among calorie, macronutrient, and micronutrient intakewith colorectal cancer: A case-control study. Food SciNutr. 2022 Apr 20;10(5):1527-36. doi: 10.1002/fsn3.2775

44. Limanova OA, Gromova OA, Torshin IYu, et al. Systematic analysis of the molecular physiological effects of myo-inositol: data from molecular biology, experimental and clinical medicine. Effektivnaya farmakoterapiya. Akusherstvo i ginekologiya = Effective Pharmacotherapy. Obstetrics and Gynecology. 2013;28(3):32-41 (In Russ.).

45. Larner J. D-chiro-inositol – its functional role in insulin action and its deficit in insulin resistance. Int J Exp Diabetes Res. 2002;3(1):47-60. doi: 10.1080/15604280212528

46. Rapiejko PJ, Northup JK, Evans T, et al. G-proteins of fat-cells. Role in hormonal regulation of intracellular inositol 1,4,5-trisphosphate. Biochem J. 1986 Nov 15;240(1):35-40. doi: 10.1042/bj2400035

47. Carlomagno G, Unfer V. Inositol safety: clinical evidences. Eur Rev Med Pharmacol Sci. 2011;15(8):931-6.

48. Greff D, Juhasz AE, Vancsa S, et al. Inositol is an effective and safe treatment in polycystic ovary syndrome: a systematic review and meta-analysis of randomized controlled trials. Reprod Biol Endocrinol. 2023 Jan 26;21(1):10. doi: 10.1186/s12958-023-01055-z

49. Greenberg JA, Bell SJ, Guan Y, Yu YH. Folic Acid supplementation and pregnancy: more than just neural tube defect prevention. Rev Obstet Gynecol. 2011 Summer;4(2):52-9.

50. Ward M. Homocysteine, folate, and cardiovascular disease. Int J Vitam Nutr Res. 2001 May;71(3):173-8. doi: 10.1024/0300-9831.71.3.173

51. Gromova OA, TorshinIYu. Rol' foliyevoy kisloty i tsiankobalamina v profilaktike patologii beremennosti i porokov razvitiya ploda. Metodicheskoye posobiye dlya vrachey [The role of folic acid and cyanocobalamin in the prevention of pregnancy pathologies and fetal malformations. Methodological manual for doctors]. Ed. VB Spirichev. Moscow: RSC Institute of Microelements UNESCO; 2012. 38 р. (In Russ.).

52. Stolzenberg-Solomon RZ, Chang SC, Leitzmann MF, et al. Folate intake, alcohol use, and postmenopausal breast cancer risk in the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial. Am J Clin Nutr. 2006;83(4):895-904.

53. Cole BF, Baron JA, Sandler RS, et al. Folic acid for the prevention of colorectal adenomas: a randomized clinical trial. JAMA. 2007;297(21):2351-9.

54. Passarelli MN, Barry EL, Rees JR, et al. Folic acid supplementation and risk of colorectal neoplasia during long-term follow-up of a randomized clinical trial. Am J Clin Nutr. 2019 Oct 1;110(4):903-11. doi: 10.1093/ajcn/nqz160

55. Sabihi S, Vahedpoor Z, Saraf-Bank S, Nourian M. Effects of folate supplementation on recurrence and metabolic status of cervical intraepithelial neoplasia grade 2/3 in overweight andobese women: a randomized double-blind placebo-controlled trial. Eur J Clin Nutr. 2022 May;76(5):666-70. doi: 10.1038/s41430-021-01022-0

56. Zargarzadeh N, Severo JS, Pizarro AB, et al. The Effects of Folic Acid Supplementation on Pro-inflammatory Mediators: a Systematic Review and DoseResponse Meta-Analysis of Randomized Controlled Trials. Clin Ther. 2021 Dec;43(12):e346-e363. doi: 10.1016/j.clinthera.2021.10.002

57. Vollset SE, Clarke R, Lewington S, et al. Effects of folic acid supplementation on overall and site-specific cancer incidence during the randomised 22 trials: meta-analyses of data on 50,000 individuals. Lancet. 2013 Mar 23;381(9871):1029-36. doi: 10.1016/S0140-6736(12)62001-7

58. Geijsen AJMR, Ulvik A, Gigic B, et al. Circulating Folate and Folic Acid Concentrations: Associations With Colorectal Cancer Recurrence and Survival. JNCI Cancer Spectr. 2020 Jul 7;4(5):pkaa051. doi:10.1093/jncics/pkaa051

59. Mortensen JH, Oyen N, Fomina T, et al. Supplemental folic acid in pregnancy and childhood cancer risk. Br J Cancer. 2016 Jan 12;114(1):71-5. doi: 10.1038/bjc.2015.446

60. Potter C, Moorman AV, Relton CL, et al. Maternal Red Blood Cell Folate and Infant Vitamin B(12) Status Influence Methylation of Genes Associated with Childhood Acute Lymphoblastic Leukemia. Mol Nutr Food Res. 2018 Nov;62(22):e1800411. doi: 10.1002/mnfr.201800411

61. Xiao Q, Freedman ND, Ren J, et al. Intakes of folate, methionine, vitamin B6, and vitamin B12 with risk of esophageal and gastric cancer in a large cohort study. Br J Cancer. 2014 Mar 4;110(5):1328-33. doi: 10.1038/bjc.2014.17

62. Mesolella M, Iengo M, Testa D, et al. Chemoprevention using folic acid for dysplastic lesions of the larynx. Mol Clin Oncol. 2017 Nov;7(5):843-6. doi: 10.3892/mco.2017.1424

63. Brown GM. The biosynthesis of folic acid. II. Inhibition by sulfonamides. J Biol Chem. 1962 Feb;237:536-40.

64. Maki T, Takeda K. Benzoic Acid and Derivatives. Ullmann's Encyclopedia of Industrial Chemistry. Wiley-VCH; 2000. doi: 10.1002/14356007.a03_555. ISBN 3527306730

65. Butcher NJ, Ilett KF, Minchin RF. Inactivation of human arylamine N-acetyltransferase 1 by the hydroxylamine of p-aminobenzoic acid. Biochem Pharmacol. 2000 Dec 15;60(12):1829-36. doi: 10.1016/s0006-2952(00)00501-3

66. Torshin IYu, Gromova OA. Neurological functions and synergism of vitamins B1, B6 and B12. Rossiyskiy zhurnal boli = Russian Journal of Pain. 2022;20(1):56-64. doi: 10.17116/pain20222001156 (In Russ.).

67. Gromova OA, Stakhovskaya LV, Torshin IYu. On the potential antitumor effect of vitamin B12. Rossiyskiy zhurnal boli = Russian Journal of Pain. 2017;(2):62-73 (In Russ).

68. Volkov I. The master key effect of vitamin B12 in treatment of malignancy – a potential therapy? Med Hypotheses. 2008;70(2):324-8. doi: 10.1016/j.mehy.2007.05.029. Epub 2007 Jul 20.

69. Arendt JF, Nexo E. Cobalamin related parameters and disease patterns in patients with increased serum cobalamin levels. PLoS One. 2012;7(9):e45979. doi:10.1371/journal.pone.0045979. Epub 2012 Sep 21.

70. Ekmekcioglu C, Wallner P, Kundi M, et al. Red meat, diseases, and healthy alternatives: A critical review. Crit Rev Food Sci Nutr. 2018 Jan 22;58(2):247-61. doi: 10.1080/10408398.2016.1158148

71. Zeng FF, Liu YT, Lin XL, et al. Folate, vitamin B6, vitamin B12 and methionine intakes and risk for nasopharyngeal carcinoma in Chinese adults: a matched case-control study. Br J Nutr. 2016 Jan 14;115(1):121-8. doi: 10.1017/S0007114515004146.

72. Matejcic M, de Batlle J, Ricci C, et al. Folic Acid and Vitamin B12 Supplementation and the Risk of Cancer: Long-term Follow-up of the B Vitamins for the Prevention of Osteoporotic Fractures (B-PROOF) Trial. Cancer Epidemiol Biomarkers Prev. 2019 Feb;28(2):275-82. doi: 10.1158/1055-9965.EPI-17-1198

73. Oliai Araghi S, Kiefte-de Jong JC, van Dijk SC, et al. Folic Acid and Vitamin B12 Supplementation and the Risk of Cancer: Long-term Follow-up of the B Vitamins for the Prevention of Osteoporotic Fractures (B-PROOF) Trial. Cancer Epidemiol Biomarkers Prev. 2019;28(2):275-82. doi: 10.1158/1055-9965.EPI-17-1198

74. Silva NNT, Silva Santos AC, Carneiro CM, Lima AA. Association of serum folate and vitamin B12 with pre-neoplastic cervical lesions. Clin Nutr ESPEN. 2020 Aug;38:223-8. doi: 10.1016/j.clnesp.2020.04.007

75. Wu W, Kang S, Zhang D. Association of vitamin B6, vitamin B12 and methionine with risk of breast cancer: a dose-response meta-analysis. Br J Cancer. 2013;109(7):1926-44.

76. Sun NH, Huang XZ, Wang SB, et al. A dose-response meta-analysis reveals an association between vitamin B12 and colorectal cancer risk. Public Health Nutr. 2016;19(8):1446-56.

77. Stoffregen CC, Odin EA, Carlsson GU, et al. Reduced folate and serum vitamin metabolites in patients with rectal carcinoma: an open-label feasibility study of pemetrexed with folic acid and vitamin B12 supplementation. Anticancer Drugs. 2016;27(5):439-46. doi: 10.1097/CAD.0000000000000345


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Gromova OA, Torshin IY, Filimonova MV, Frolova DE. On the antitumour effects of B vitamins. Nevrologiya, neiropsikhiatriya, psikhosomatika = Neurology, Neuropsychiatry, Psychosomatics. 2024;16(1):102-113. (In Russ.) https://doi.org/10.14412/2074-2711-2024-1-102-113

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