Neurology, Neuropsychiatry, Psychosomatics

Advanced search

Effect of drug formulation on the treatment of epilepsy

Full Text:


The paper describes a trial dealing with the effect of the formulation of an antiepileptic drug on therapy efficiency, safety, and compliance in epileptic patients. Switching from sustained-release valproates to Depakine®Chronosphere™ demonstrates how the values of efficiency, safety, and compliance vary with the taken dosage form, which ultimately affects quality-of-life indicators and may give rise to their improvement.

About the Author

S. G. Burd
Department of Neurology, Neurosurgery, and Medical Genetics, N.I. Pirogov Russian National Research Medical University Ministry of Health of Russia, Moscow
Russian Federation


1. <div><p>Mulleners W.M., Whitmarsh T.E., Steiner T.J. Noncompliance may render migraine prophylaxis useless, but once-daily regimens are better. Cephalalgia 1998;18(1):52–6.</p><p>Белоусова Е.Д. Лечение эпилепсии у детей: специальные лекарственные формы. Эпилепсия и пароксизмальные состояния 2009;1(1):26–30.</p><p>Таточенко В.К. Антибиотики в лекарственной форме Салютаб. Фарматека 2010;14:46–50.</p><p>Yu P.M., Zhu G.X., Wu X.Y. et al. Seizure 2011;20(1):23–6.</p><p>Зенков Л.Р., Яхно Н.Н., Усачева Е.Л. Депакин хроно в лечении эпилепсии, резистентной к другим препаратам. Неврологический журнал 2000;5(4):39–42.</p><p>Smith M.C., Centorrino F., Welge J.A., Collins M.A. Epilepsy Behav 2004;5(5):746–51.</p><p>Pierre-Louis S.J., Brannegan R.T., Evans A.T. Clin Neurol Neurosurg 2009;111(5):437.</p><p>Bialer M. CNS Drugs 2007;21(9):765–74.</p><p>Белоусова Е.Д. и др. Невролог нейропсихиатр и психосом 2009;3–4:25–32.</p><p>Bergmann A., Schmidt D., Hutt H.J., Elger C.E. Epilepsy treatment with a sustained-release formulation of valproate - experience with 1172 patients. Actuelle Neurologie, 1999;26:1–5.</p><p>Owens M.J., Nemeroff C.B. Psychopharmacol Bull 2003;37(Suppl 2):17–24.</p><p>Todorovic S.M., Lingle C.J. J Neurophysiol 1998;79(1):240–52.</p></div><br />


For citations:

Burd S.G. Effect of drug formulation on the treatment of epilepsy. Neurology, Neuropsychiatry, Psychosomatics. 2013;5(1S):12-19. (In Russ.)

Views: 611

Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 License.

ISSN 2074-2711 (Print)
ISSN 2310-1342 (Online)