Роль клеточного иммунитета и коэффициентов системного воспаления в механизмах формирования психических расстройств

В настоящее время известно, что воспалительные механизмы участвуют в нейрональном повреждении и формировании сопряженных психических нарушений, однако большинство работ было сосредоточено главным образом на цитокинах и других маркерах воспаления, являющихся трудно воспроизводимыми и мало экономически выгодными для использования в клинической практике. В то же время другими крайне важными показателями системного воспалительного процесса являются циркулирующие клетки крови иизменения их числа, состава исоотношения. Всоматическом звене уже используются гематологические коэффициенты системного воспаления (ГКСВ): нейтрофильно-лимфоцитарное, моноцитарно-лимфоцитарное и тромбоцитарно-лимфоцитарное соотношения, а также индексы системного иммунного воспаления и системной воспалительной реакции. В рамках психопатологии ГКСВ требуют дополнительного изучения, что заставляет подробнее обратить внимание на возможные механизмы, лежащие в основе их изменений. В статье содержатся данные о вкладе каждого отдельного клеточного элемента в механизм нейровоспаления и нейродегенерации, а также их роли в формировании психопатологических процессов.

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