Preview

Neurology, Neuropsychiatry, Psychosomatics

Advanced search

Epidemiology and etiology of strokes in babies

https://doi.org/10.14412/2074-2711-2013-2359

Full Text:

Abstract

The paper summarizes an update on the morbidity, mortality, and a risk for recurrence of stroke occurring in babies. It shows a variety of conditions and syndromes which may be responsible for stroke in infancy. Babies with the signs of intrauterine infection and congenital heart disease, the carriers of major thrombophilia gene mutations, may be regarded as a risk group.

About the Authors

Olga Aleksandrovna Lvova
Department of Child and Neonatal Neurology, Ural State Medical Academy, Ministry of Health of Russia, Yekaterinburg
Russian Federation


N N Kuznetsov
Department of Pediatrics and Neonatology, Ural State Medical Academy, Ministry of Health of Russia, Yekaterinburg
Russian Federation


V V Gusev
Department of Child and Neonatal Neurology, Ural State Medical Academy, Ministry of Health of Russia, Yekaterinburg
Russian Federation


S A Volkhina
Department of Child and Neonatal Neurology, Ural State Medical Academy, Ministry of Health of Russia, Yekaterinburg
Russian Federation


References

1. <div><p>Lynch JK. Cerebrovascular disorders in children. Curr Neurol Neurosci Rep. 2004 Mar;4(2):129–38.</p><p>Lynch JK, Hirtz DG, DeVeber G, Nelson KB. Report of the National Institute of Neurological Disorders and Stroke Workshop on Perinatal and Childhood Stroke. Pediatrics. 2002;109(1):116–23.</p><p>Nelson K. Perinatal ischemic stroke. Режим доступа: http:// www.medicineinfo.msk.ru/emd11t9g.htm. (дата обращения 02.07.2013).</p><p>Шнайдер НА. Детский инсульт. Практическая ангиология. 2007;3(8). Режим доступа:</p><p>http://angiology.com.ua//cgi-bin/articles.pl/83.html?choice=view&amp;art=83.html (дата обращения 01.07.2013). [Shnayder NA. Detskiy insul't. Prakticheskaya angiologiya. 2007;3(8). Rezhim dostupa: http://angiology.com.ua//cgibin/articles.pl/83.html?choice=view&amp;art=83.html (data obrashcheniya 01.07.2013).]</p><p>Abram H, Knepper L, Warty V, Painter M. Natural history, prognosis and lipid abnormalities of idiopathic ischemic childhood stroke. J Child Neurol. 1996;11(4):276–82.</p><p>DeVeber G, Adams M, Andrew M et al. Canadian pediatric ischemic stroke registry (analysis III). Can J Neurol Sci. 1995;22 (Suppl 1):21–4.</p><p>Ganesan V, Prengler M, McShane M et al. Investigation of risk factors in children with arterial ischemic stroke. Режим доступа: http://www.cardiosite.ru/new.asp?id=21826 (дата обращения 24.06.2013).</p><p>Кривопустов СП, Волосовец АП. Инсульт головного мозга и инфаркт миокарда у детей: современный взгляд на проблему. Режим доступа: http://www.pediatric.mif - ua.com/archive/issue - 922/article - 961/print.html (дата обращения 01.07.2013). [Krivopustov SP, Volosovets AP. Insul't golovnogo mozga i infarkt miokarda u detey: sovremennyy vzglyad na problemu. Rezhim dostupa: http://www.pediatric.mif - ua.com/archive/issue - 922/article - 961/print.html (data obrashcheniya 01.07.2013).</p><p>Fullerton HJ, Chetkovich DM, Wu YW et al. Deaths from stroke in US children, 1979 to 1998. Neurology. 2002;59(1):34–9.</p><p>Launthier S, Carmant L, David M et al. Stroke in children: The coexistence of multiple risk factors predicts poor outcome. Neurology. 2000;54(2):371–8.</p><p>Kramarow E, Lentzner H, Rooks R et al. Health and Aging Chart book. National Center for Health Statistics (USА). Hyattsville. 1999;32–8.</p><p>Pavlakis SG, Levinson K. Arterial ischemic stroke: common risk factors in newborns and children. Stroke. 2009;40(3 Suppl):S79–81. DOI: 10.1161/STROKEAHA.108.531749.</p><p>Writing Group of the American Heart Association Stroke Council and the Council on Cardiovascular Disease in the Young «Management of Stroke in Infants and Children. A Scientific Statement From a Special Writing Group of the American Heart Association Stroke Council and the Council on Cardiovascular Disease in the Young». Stroke. 2008;39(9):2644–91. DOI: 10.1161/STROKEAHA.108.189696.</p><p>Kirkham FJ, Prengler M, Hewes DK et al. Risk factors for arterial ischemic stroke in children. J Child Neurol. 2000;15(5):299–307.</p><p>Ganesan V, Chong K, Evans J et al. (The Pediatric Stroke Working Group) «Stroke in childhood: clinical guidelines for diagnosis, management and rehabilitation». Режим доступа: http://www.rcplondon.ac.uk/pubs/books/childstroke/childstroke_guidelines.pdf (дата обращения 24.06.2013).</p><p>Miller SP, McQuillen PS, Hamrick S et al. Abnormal brain development in newborns with congenital heart diseas. N Engl J Med. 2007 Nov: 8;357(19):1928–38.</p><p>Rotta NT, Ranzan J et al. Ischemic stroke in children: a study of the associated alterations. Arq Neuropsiquiatr. 2006;60:959–63.</p><p>Scher MS, Wiznitzer M, Bangert BA. Cerebral infarctions in the fetus and neonate: maternal - placental - fetal considerations. Clin Perinatol. 2002;29(4):693–724.</p><p>Львова ОА, Ковтун ОП, Кузнецов НН и др. Значимость аллельных вариантов генов системы гемостаза и фолатного цикла у детей с дебютом поражения ЦНС в грудном возрасте. Пермский медицинский журнал. 2012;29(5):51–62. [L'vova OA, Kovtun OP, Kuznetsov NN i dr. Znachimost' allel'nykh variantov genov sistemy gemostaza i folatnogo tsikla u detey s debyutom porazheniya TsNS v grudnom vozraste. Permskiy meditsinskiy zhurnal. 2012;29(5):51–62.]</p><p>Роач ЕС, Биллер Дж. Сосудистые заболевания головного мозга и спинного мозга у детей и молодых взрослых. Новости медицины и фармации. 2008;260:7–23. [Roach ES, Biller Dzh. Sosudistye zabolevaniya golovnogo mozga i spinnogo mozga u detey i molodykh vzroslykh. Novosti meditsiny i farmatsii. 2008;260:7–23.]</p><p>Kittner S. Stroke in the young: coming of age. Neurоlogy. 2002;59(1):6–7.</p><p>Kenet G, Lütkhoff LK, Albisetti M, Bernard T. et al. Impact of thrombophilia on risk of arterial ischemic stroke or cerebral sinovenous thrombosis in neonates and children: a systematic review and meta - analysis of observational studies. Circulation. 2010; 121 (16):1838–47. DOI: 10.1161/CIRCULATIONAHA.109.913673.</p><p>Dowling MM, Hynan LS, Lo W et al. International Paediatric Stroke Study: stroke associated with cardiac disorders. Int J Stroke. 2012 Dec: 11; DOI: 10.1111/j.1747–4949.</p><p>Agnetti A, Carano N, Sani E et al. Cryptogenic stroke in children: possible role of patent foramen ovale. Neuropediatrics. 2006;37(1):53–6.</p><p>Bartz PJ, Cetta F, Cabalka AK et al. Paradoxical emboli in children and young adults: role of atrial septal defect and patent foramen ovale device closure. Mayo Clin Proc. 2006;81(5):615–8.</p><p>Евтушенко СК, Евтушенко ОС, Перепечаенко ЮМ, Москаленко МА. Инсульты у детей и их причины. Журнал неврологии и психиатрии 2003;103 (приложение «Инсульт»):30–5. [Evtushenko SK, Evtushenko OS, Perepechaenko YuM, Moskalenko MA. Insul'ty u detey i ikh prichiny. Zhurnal nevrologii i psikhiatrii 2003;103 (prilozhenie «Insul't»):30–5.]</p><p>Block AJ, McQuillen PS, Chau V et al. Clinically silent preoperative brain injuries do not worsen with surgery in neonates with congenital heart disease. J Thorac Cardiovasc Surg. 2010 Sep;140(3):550–7. DOI: 10.1016/j.jtcvs.2010.03.035.</p><p>McQuillen PS, Hamrick SE, Perez MJ et al. Ballon atrial septostomy is associated with preoperative stroke in neonates with transposition of the great arteries. Circulation. 2006 Jan:17;113(2):280–5.</p><p>Rodan L, McCrindle BW, Manlhiot C et al. Stroke recurrence in children with congenital heart disease. Ann Neurol. 2012 Jul;72(1):103–11. DOI: 10.1002/ana.23574.</p><p>Goff D, Luan X, Gerdes M еt al. Younger gestational age is associated with worse neurodevelopmental outcomes after cardiac surgery in infancy. J Thorac Cardiovasc Surg. 2012 Mar;143(3):535–42. DOI: 10.1016/j.jtcvs.2011.11.029.</p><p>Petit CJ, Rome JJ, Wernovsky G. Preoperative brain injury in transposition of the great arteries is associated with oxygenation and time to surgery, not balloon atrial septostomy. Circulation. 2009 Feb:10;119(5):709–16. DOI: 10.1161/CIRCULATIONAHA.107.760819.</p><p>Sethi V, Tabbutt S, Dimitropoulos A et al. Single - ventricle anatomy predicts delayed microstructural brain development. Pediatr Res. 2013 May;73(5):661–7. DOI: 10.1038/pr.2013.29.</p><p>Soul JS, Robertson RL, Wypij D et al. Subtle hemorrhagic brain injury is associated with neurodevelopmental impairment in infants with repaired congenital heart disease. J Thorac Cardiovasc Surg. 2009 Aug;138(2):374–81. DOI: 10.1016/j.jtcvs.2009.02.027.</p><p>Kenet G, Sadetzki S, Murad H et al. Factor V Leiden and antiphospholipid antibodies are significant risk factors for ischemic stroke in children. Stroke. 2000;31(6):1283–8.</p><p>Kirkham FJ. Is there a genetic basis for pediatric stroke? Curr Opin Pediatr. 2003;15(6):547–58.</p><p>Ранние ишемические инсульты и гематогенные тромбофилии: методическое пособие для врачей. Под ред. А.П. Момота. Барнаул, 2009;58. [Rannie ishemicheskie insul'ty i gematogennye trombofilii: metodicheskoe posobie dlya vrachey. Pod red. A.P. Momota. Barnaul, 2009;58.]</p><p>British Committee for Standards in Haematology (BCSH). Guidelines on the investigation and management of thrombophilia. J Clin Pathol. 1990;(43):703–10.</p><p>Jordan FLJ, Nandorff A. The familial tendency in thromboembolic disease. Acta Med Scand.1956;156(4):267–75.</p><p>Баркаган ЗС. Клинико-патогенетические варианты, номенклатура и основы диагностики гематогенных тромбофилий. Проблемы гематологии и переливания крови 1996;(3):5–15. [Barkagan ZS. Kliniko-patogeneticheskie varianty, nomenklatura i osnovy diagnostiki gematogennykh trombofiliy. Problemy gematologii i perelivaniya krovi 1996;(3):5–15.]</p><p>Bonduel M, Sciuccati G, Hepner M et al. Factor V Leiden and prothrombin gene G20210A mutation in children with cerebral thromboembolism. Am J Hematol. 2003;73(2):81–6.</p><p>Akar N, Akar E, Deda G et al. Co-existence of two prothrombotic mutations, factor V 1691 G - A and prothrombin gene 20210 G - A, and the risk of cerebral infarct in pediatric patients. Pediatr Hematol Oncol. 1999;16(6):565–6.</p><p>Bivona G, Bellia C, Cammarieri S et al. Plasminogen activator inhibitor - 1 - 675 4G/5G and methylenetetrahydrofolate reductase gene variants in young acute myocardial infarction and juvenile ischemic stroke. Res J Biol Sci. 2001;3(11):1341–3.</p><p>De Stefano V, Chiusolo P, Paciaroni K et al. Prothrombin G20210A mutant genotype is a risk factor for cerebrovascular ischemic disease in young patients. Blood 1998;91(10):3562–5.</p><p>Nowak - Göttl U, Sträter R, Heinecke A et al. Lipoprotein (a) and Genetic Polymorphisms of Clotting Factor V, Prothrombin, and Methylentetrahydrofolate Reductase Are Risk Factors of Spontaneous Ischemic Stroke in Childhood. Blood. 1999;94(11):3678–82.</p><p>Гомелля МВ, Большакова СЕ, Филиппов ЕС и др. Изменчивость генетических маркеров протромботических нарушений у детей. Сибирский медицинский журнал. 2009;91(8):5–7. [Gomellya MV, Bolshakova SE, Philippov ES et al. The variability of the genetic markers of the prothrombotic disfunctions in children. Sibirskiy meditsinskiy zhurnal. 2009;91(8):5–7.]</p><p>De Marco P, Calevo MG, Moroni A et al. Study of MTHFR and MS polymorphisms as risk factors for NTD in the Italian population. J Hum Genet. 2002;47(6):319–24.</p><p>Kim O., Hong SP, Ahn JY et al. Influence of combined methionine synthase (MTR 2756A&gt;G) and methylentetrahydrofolate reductase (MTHFR 677 C&gt;T) polymorphisms to plasma homocysteine levels in Korean patients with ischemic stroke. Yonsei Med J. 2007;48(2):201–9.</p><p>Miller P, Wu YW, Lee J et al. Candidate Gene Polymorphisms Do Not Differ Between Newborns With Stroke and Normal Controls. Stroke. 2006;37(11):2678.</p><p>Malinow MR. Homocystein and arterial occlusive disease. J Intern Med. 1994;236:603–17.</p><p>Udas A, Williams EB, Butenas S et al. Homocysteine inhibits inactivation of factor Va by activated protein C. J Biol Chem 2001;276(6):4389–97.</p><p>Шевченко ОП, Олефриенко ГА. Гипергомоцистеинемия и ее клиническое значение. Лаборатория. 2002;(1):3–7. [Shevchenko OP, Olefrienko GA. Gipergomotsisteinemiya i ee klinicheskoe znachenie. Laboratoriya. 2002;(1):3–7.]</p><p>Cardo E, Monros E, Colome C et al. Children with stroke: polymorphism of the MTHFR gene, mild hyperhomocysteinemia, and vitamin status. J Child Neurol. 2000;15(5):295–8.</p><p>Weisberg I, Tran P, Christensen B et al. A second genetic polymorphism in methylenetetrahydrofolate reductase (MTHFR) associated with decreased enzyme activity. Mol Genet Metab. 1998;64(3):169–72.</p><p>Zak I, Sarecka-Hujar B, Kopyta I et al. The T allele of the 677C&gt;T polymorphism of methylenetetrahydrofolate reductase gene is associated with an increased risk of ischemic stroke in Polish children. J Child Neurol. 2009;24(10):1262–7.</p><p>Franco RF, Araujo AG, Guerreiro JF et al. Analysis of the 677C - T mutation of the methylentetrahydrofolate reductase gene in different ethnic groups. Thromb Haemost. 1998;79(1):119–21.</p><p>Hills NK, Johnston SC, Sidney S et al. Recent trauma and acute infection as risk factors for childhood arterial ischemic stroke. Ann Neurol. 2012 Dec;72(6):850–8.</p><p>Tiah AL, Phelan E, McMenamin J, Webb D. Childhood Stroke Following Varicella Infection. Ir Med J. 2004 Apr;97(4):120–1.</p><p>Fullerton HJ, Elkind MS, Barkovich AJ et al. The vascular effects of infection in Pediatric Stroke (VIPS) Study. J Child Neurol. 2011 Sep;26(9):1101–10.</p><p>Iannetti L, Zito R, Bruschi S et al. Recent understanding on diagnosis and management of central nervous system vasculitis in children. Clin Dev Immunol. 2012; DOI: 698327.</p><p>Kurihara T. Headache, Neck Pain, and Stroke as Characteristic Manifestations of the Cerebral Artery Dissection. Japanese Society Intern Med 2007;46(6):257–8.</p><p>Benseler SM, deVeber G, Hawkins C et al. Angiography - negative primary central nervous system vasculitis in children: a newly recognized inflammatory central nervous system disease. Arthr Rheum. 2005;52(7):2159–67.</p><p>Benseler SM, Silverman E, Aviv RI, Schneider R et al. Primary central nervous system vasculitis in children. Arthr Rheum. 2006;54(4):1291–7.</p><p>Baranov D, Kovtun O, Kuznetsov N, Lvova O. Gene’s polymorphism of the haemostasis and folic acid cycle’s enzymes in infants with family’s thrombophilic susceptibility. J Perinat Med. 2013;41 (s1):777.</p><p>Ковтун ОП, Львова ОА. Современные взгляд на эпидемиологию и этиологию острых нарушений мозгового кровообращения у детей грудного возраста. Уральский медицинский журнал. 2011;(7):11–6. [Kovtun OP, Lvova OA. The contemporary view through stroke etiology and epidemiology in infants. Ural'skiy meditsinskiy zhurnal. 2011;(7):11–6.]</p><p>Корнюшина ЕА, Зайнулина МС. Нарушения системы гемостаза, методы их коррекции и исходы беременности у больных с невынашиванием и тромбофилией. Журнал акушерства и женских болезней. 2008;LVII(4):89–95.</p><p>[Kornjushina EA, Zainulina MC. Abnormalities of coagulation system, methods of their correction and pregnancy outcomes in patients with thrombophilia and miscarriage. Zhurnal akusherstva i zhenskikh bolezney. 2008;LVII(4):89–95.]</p><p>Плаксина АН. Прогнозирование здоровья и качества жизни детей, рожденных с помощью вспомогательных репродуктивных технологий. Автореф. дис. … канд. мед. наук. Екатеринбург, 2011;27. [Plaksina AN. Prognozirovanie zdorov'ya i kachestva zhizni detey, rozhdennykh s pomoshch'yu vspomogatel'nykh reproduktivnykh tekhnologiy. Avtoref. dis. … kand. med. nauk. Ekaterinburg, 2011;27.]</p><p>Carlin T, Chanmugam A. Stroke in children. Emergency Med Clinics North Am. 2002;20(3):671–85.</p></div><br />


For citation:


Lvova O.A., Kuznetsov N.N., Gusev V.V., Volkhina S.A. Epidemiology and etiology of strokes in babies. Neurology, Neuropsychiatry, Psychosomatics. 2013;5(2S):50-55. (In Russ.) https://doi.org/10.14412/2074-2711-2013-2359

Views: 761


Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 License.


ISSN 2074-2711 (Print)
ISSN 2310-1342 (Online)