nnpNeurology, Neuropsychiatry, PsychosomaticsНеврология, нейропсихиатрия, психосоматика2074-27112310-1342"IMA-Press", LLC10.14412/2074-2711-2023-1S-35-42nnp-2077Research ArticleCLINICAL OBSERVATIONSКЛИНИЧЕСКИЕ НАБЛЮДЕНИЯClinical course features of atypical demyelinating optic neuritis: case seriesОсобенности клинического течения атипичных демиелинизирующих оптических невритов: серия клинических наблюденийhttps://orcid.org/0000-0003-4597-4987ШереметН. Л.SheremetN. L.

Наталия Леонидовна Шеремет

119021, Москва, ул. Россолимо, 11А, Б

Nataliya Leonidovna Sheremet

11А, Б, Rossolimo St., Moscow 119021

sheremet_n@mail.ruhttps://orcid.org/0000-0003-2173-927XЕлисееваД. Д.EliseevaD. D.

125367, Москва, Волоколамское ш., 80

80, Volokolamskoe Shosse, Moscow 125367

https://orcid.org/0000-0002-1645-6526БрюховВ. В.BryukhovV. V.

125367, Москва, Волоколамское ш., 80

80, Volokolamskoe Shosse, Moscow 125367

https://orcid.org/0000-0001-7329-5725АндрееваН. А.AndreevaN. A.

119021, Москва, ул. Россолимо, 11А, Б

11А, Б, Rossolimo St., Moscow 119021

https://orcid.org/0000-0003-1771-300XЖоржоладзеН. В.ZhorzholadzeN. V.

119021, Москва, ул. Россолимо, 11А, Б

11А, Б, Rossolimo St., Moscow 119021

https://orcid.org/0000-0002-1251-6405МураховскаяЮ. К.MurakhovskayaYu. K.

119021, Москва, ул. Россолимо, 11А, Б

11А, Б, Rossolimo St., Moscow 119021

https://orcid.org/0000-0002-2229-384XКалашниковаА. К.KalashnikovaA. K.

119021, Москва, ул. Россолимо, 11, стр. 1

11А, Б, Rossolimo St., Moscow 119021

https://orcid.org/0000-0002-1072-9968ЗахароваМ. Н.ZakharovaM. N.

125367, Москва, Волоколамское ш., 80

80, Volokolamskoe Shosse, Moscow 125367

ФГБНУ «Научно-исследовательский институт глазных болезней им. М.М. Краснова»РоссияM.M. Krasnov Research Institute of Eye DiseasesRussian FederationФГБНУ «Научный центр неврологии»РоссияResearch Center of NeurologyRussian Federationкафедра нервных болезней и нейрохирургии Института клинической медицины им. Н.В. Склифосовского ФГАОУ ВО «Первый Московский государственный медицинский университет им. И.М. Сеченова» Минздрава России (Сеченовский Университет)РоссияDepartment of Nervous System Diseases and Neurosurgery, I.M. Sechenov First Moscow State Medical University, Ministry of Health of Russia (Sechenov University)Russian Federation202321082023150(Suppl. 1)3542Copyright © Sheremet N.L., Eliseeva D.D., Bryukhov V.V., Andreeva N.A., Zhorzholadze N.V., Murakhovskaya Y.K., Kalashnikova A.K., Zakharova M.N., 20232023Шеремет Н.Л., Елисеева Д.Д., Брюхов В.В., Андреева Н.А., Жоржоладзе Н.В., Мураховская Ю.К., Калашникова А.К., Захарова М.Н.Sheremet N.L., Eliseeva D.D., Bryukhov V.V., Andreeva N.A., Zhorzholadze N.V., Murakhovskaya Y.K., Kalashnikova A.K., Zakharova M.N.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://nnp.ima-press.net/nnp/article/view/2077

Optic neuritis (ON) can often occur at the onset of a demyelinating autoimmune CNS disease or as one of its clinical manifestations. The introduction of novel laboratory techniques, technical advances in magnetic resonance imaging (MRI), electrophysiologic studies, and ocular imaging have significantly expanded the spectrum of autoimmune optic neuropathies. Identification of different forms of ON based on clinical and instrumental data can lead to early diagnosis of the underlying neurologic disorder. According to current guidelines, one can distinguish between typical ON, which are mainly associated with multiple sclerosis (MS), and atypical ON, which are the main clinical manifestation of neuromyelitis optica spectrum disorders (NMOSD) and diseases associated with myelin oligodendrocyte glycoprotein antibodies (MOGAD). In this paper, we present four clinical cases of atypical ON at the onset of NMOSD and MOGAD and illustrate the high diagnostic value of a multidisciplinary approach.

Оптические невриты (ОН) часто могут развиваться в дебюте или быть одним из симптомов аутоиммунных демиелинизирующих заболеваний ЦНС. Создание новых методов лабораторной диагностики, совершенствование технических возможностей магнитно-резонансной томографии (МРТ), электрофизиологии и визуализации глаза значительно расширили спектр аутоиммунных невропатий зрительного нерва. Выделение различных типов ОН, с учетом клинических и инструментальных данных, позволяет сократить время до постановки диагноза основного неврологического заболевания. Согласно современным рекомендациям, необходимо выделять типичные ОН, развивающиеся в основном в рамках рассеянного склероза (РС), и атипичные ОН, являющиеся ведущими синдромами заболеваний спектра оптиконевромиета (ЗСОНМ) и заболеваний, ассоциированных с антителами к миелинолигодендроцитарному гликопротеину (МОГАР). В статье разбираются четыре клинических случая атипичного ОН в дебюте ЗСОНМ и МОГАР и подчеркивается высокая диагностическая ценность мультидисциплинарного подхода.

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The authors declare that there are no conflicts of interest present.