Vitamin B12 deficiency and Parkinson’s disease
https://doi.org/10.14412/2074-2711-2023-3-121-127
Abstract
Parkinson’s disease (PD) is a progressive neurodegenerative disease with various clinical manifestations, its origin not always can be explained only by dopamine deficiency. Long-term treatment with levodopa (especially its intraduodenal administration), as well as clinical manifestations of polyneuropathy, cognitive deficits, postural disorders with freezing of gate, REM sleep behavioral disorders, are more often associated with vitamin B12 deficiency. Several reasons for this association and mechanisms of their development are discussed. Early detection of cobalamin deficiency in PD, especially in patients from high-risk groups, makes it possible to stop this pathological condition timely and prevent irreversible changes. Modern data on the use of high-dose (1000 μ g) oral vitamin B12 are presented, it has comparable clinical efficacy and significant advantages, compared with the parenteral form, in terms of the ease of use and the ability to avoid undesirable postinjection reactions.
Keywords
vitamin B12 deficiency,
Parkinson’s disease,
levodopa,
combined levodopa drugs,
cyanocobalamin,
high-dose vitamin B12,
oral form of vitamin B12
Supporting agencies: This article has been supported by Woerwag Pharma
About the Authors
Z. A. Zalyalova
Kazan State Medical University, Ministry of Health of Russia; Consultative and Diagnostic Center for Extrapyramidal Pathology and Botulinum Toxin Therapy of the Republic of Tatarstan
Russian Federation
Competing Interests:
Russian Federation
Zuleikha Abdullazyanovna Zalyalova
49, Butlerova St., Kazan 420012; 5, Isaeva St., Kazan 420039
Competing Interests:
The conflict of interest has not affected the results of the investigation
E. V. Ekusheva
Academy of Postgraduate Education, Federal Scientific and Clinical Center for Specialized Types of Medical Aid and Medical Technologies, FMBA of Russia; Belgorod State National Research University
Russian Federation
Competing Interests:
Russian Federation
91, Volokolamskoe Shosse, Moscow 125371; 85, Pobedy St., Belgorod 308015
Competing Interests:
The conflict of interest has not affected the results of the investigation
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For citations:
Zalyalova ZA, Ekusheva EV. Vitamin B12 deficiency and Parkinson’s disease. Nevrologiya, neiropsikhiatriya, psikhosomatika = Neurology, Neuropsychiatry, Psychosomatics. 2023;15(3):121-127. (In Russ.) https://doi.org/10.14412/2074-2711-2023-3-121-127
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