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Impact of depression on the quality of life of patients with multiple sclerosis

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Multiple sclerosis (MS) is a neurodegenerative disease that leads to multiple focal and diffuse lesions of the central nervous system, resulting in disability of patients. Currently the impact of depression on the quality of life (QoL) of MS patients has been little studied.

Objective: to study the effect of depressive disorders on the QoL of patients with MS, to search for factors influencing the development of depression in patients with MS.

Material and methods. The study involved 203 MS patients aged 15 to 60 years (mean age 39.7±10.91 years). Disability according to the EDSS scale was 2.51±1.45 points, the average duration of the disease was 8.07±7.22 years. The comparison group consisted of 52 healthy people aged 24 to 43 years (mean age 31.86±6.98 years).

Results. Patients with MS in more than half of cases (55.7%) suffer from depressive disorders. In MS patients there was an association of depression with older age, a longer duration of the disease, as well as a higher level of disability and exacerbations (p<0.001). MS patients with depression significantly more often (p<0.01) complained of increased fatigue and had higher scores on the scales of asthenia, situational and personal anxiety, and were also exposed to stressful influences and tolerated them poorly; they were more likely than those of the control group to had depressive episodes earlier. MS patients with depression had lower scores (p<0.001) for all QoL criteria, which further accelerated their disability and social isolation.

Conclusion. Depression in MS patients has a negative impact on all QoL indicators.

About the Authors

N. V. Zarubina
Yaroslavl State Medical University, Ministry of Health of Russia; Scientific and Practical Center for Mental Health of Children and Adolescents named after G.E. Sukhareva
Russian Federation

Natalya Vladimirovna Zarubina

5, Revolutzionnaya St., Yaroslavl 150000; 21A, 5th Donskoy proezd, Moscow 119334

Competing Interests:

There are no conflicts of interest

N. N. Spirin
Yaroslavl State Medical University, Ministry of Health of Russia
Russian Federation

5, Revolutzionnaya St., Yaroslavl 150000

Competing Interests:

There are no conflicts of interest


1. Novik AA, Ionova TI, Kaynd P. Kontseptsiya issledovaniya kachestva zhizni v meditsine [The concept of studying the quality of life in medicine]. St. Petersburg: Elby; 1999. 140 p. (In Russ.).

2. Novik AA, Ionova TI. Rukovodstvo po issledovaniyu kachestva zhizni v meditsine [Guidelines for the study of quality of life in medicine]. Ed. acad. RAMS Yu.L. Shevchenko. 2nd ed. Moscow: ZAO Olma Media Group; 2007. 320 p. (In Russ.).

3. Smulevich AB. Psikhosomaticheskiye rasstroystva v klinicheskoy praktike [Psychosomatic disorders in clinical practice]. Moscow; 2016. 776 p. (In Russ).

4. Senkevich NYu, Belevskiy AS. Quality of life is the subject of scientific research in pulmonology. Terapevticheskiy arkhiv. 2000;72(3):36-41 (In Russ.).

5. Sapolsky RM. Stress, Glucocorticoids, and Damage to the Nervous System: The Current State of Confusion. Stress. 1996 Jul;1(1):1-19. doi: 10.3109/10253899609001092

6. Tadic D, Dajic V. Quality of life in patients with multiple sclerosis in Republic of Srpska. Med Glas (Zenica). 2013 Feb;10(1):113-9.

7. Boyko OV. Quality of life in patients with multiple sclerosis (a review). Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova. 2014;114(102):105-13 (In Russ.).

8. Pushkar’ DYu, D’yakov VV, Bernikov AN. Quality of life is a new paradigm of medicine. Farmateka. 2005;(11):15-6 (In Russ.).

9. Gusev YEI, Boyko AN, Stolyarov ID. Rasseyannyy skleroz: Spravochnik [Multiple sclerosis: a Handbook]. Moscow: Real Taym; 2009. P. 204 (In Russ.).

10. Schmidt S, Jöstingmeyer P. Depression, fatigue and disability are independently associated with quality of life in patients with multiple Sclerosis: Results of a cross-sectional study. Mult Scler Relat Disord. 2019 Oct;35:262-9. doi: 10.1016/j.msard.2019.07.029. Epub 2019 Jul 28.

11. Ochoa-Morales A, Hernandez-Mojica T, Paz-Rodriguez F, et al. Quality of life in patients with multiple sclerosis and its association with depressive symptoms and physical disability. Mult Scler Relat Disord. 2019 Nov;36:101386. doi: 10.1016/j.msard.2019.101386. Epub 2019 Sep 9.

12. Gusev EI, Demina TL, Boyko AN. Rasseyannyy skleroz [Multiple sclerosis]. Moscow: Neft’ i gaz; 1997 (In Russ.).

13. Protokol vedeniya bol’nykh “Rasseyannyy skleroz” [Protocol for the management of patients with multiple sclerosis]. Moscow; 2005 (In Russ.).

14. Alekseyenko EV, Sysoyeva OS, Smagina IV, Fedyanin SA. Some changes of psychologic status of patients having multipled sclerosis. Byulleten’ sibirskoy meditsiny = Bulletin of Siberian Medicine. 2008;7(5-1):11-2. doi: 10.20538/1682-0363-2008-5-1-11-12 (In Russ.).

15. Shahrbanian S, Duquette P, Kuspinar A, Mayo NE. Contribution of symptom clusters to multiple sclerosis consequences. Qual Life Res. 2015 Mar;24(3):617-29. doi: 10.1007/s11136-014-0804-7. Epub 2014 Sep 17.

16. Grech LB, Kiropoulos LA, Kirby KM, et al. The effect of executive function on stress, depression, anxiety, and quality of life in multiple sclerosis. J Clin Exp Neuropsychol. 2015;37(5):549-62. doi: 10.1080/13803395.2015.1037723. Epub 2015 May 26.

17. Alsaadi T, Hammasi KE, Shahrour TM, et al. Depression and anxiety as determinants of health-related quality of life in patients with multiple sclerosis – United Arab Emirates. Neurol Int. 2017 Dec 11;9(4):7343. doi: 10.4081/ni.2017.7343

18. Fernandez-Munoz JJ, Cigaran-Mendez M, Navarro-Pardo E, et al. Is the association between health-related quality of life and fatigue mediated by depression in patients with multiple sclerosis? A Spanish cross-sectional study. BMJ Open. 2018 Jan 23;8(1):e016297. doi: 10.1136/bmjopen-2017-016297

19. Nourbakhsh B, Julian L, Waubant E. Fatigue and depression predict quality of life in patients with early multiple sclerosis: a longitudinal study. Eur J Neurol. 2016 Sep;23(9):1482-6. doi: 10.1111/ene.13102. Epub 2016 Jul 14.

20. Gainotti G, Antonucci G, Marra C, Paolucci S. Relation between depression after stroke, antidepressant therapy, and functional recovery. J Neurol Neurosurg Psychiatry. 2001 Aug;71(2):258-61. doi: 10.1136/jnnp.71.2.258

21. Karnaukh VN, Lugovtsova YuA, Barabash IA. Dynamics of quality of life indicators at a multiple sclerosis. Byulleten’ sibirskoy meditsiny = Bulletin of Siberian Medicine. 2010;9(4):63-9. doi: 10.20538/1682-0363-2010-4-63-69 (In Russ.).

22. Shamova T, Pekarskaya YV, Prudilo A. Quality of life in patients with multiple sclerosis. Zhurnal GrGMU = Journal GrSMU. 2015;(4):126-8. Available from: (In Russ.).

23. Klevan G, Jacobsen CO, Aarseth JH, et al. Health related quality of life in patients recently diagnosed with multiple sclerosis. Acta Neurol Scand. 2014 Jan;129(1):21-6. doi: 10.1111/ane.12142. Epub 2013 Jun 15.

24. Calandri E, Graziano F, Borghi M, et al. Depression, positive and negative affect, optimism and health-related quality of life in recently diagnosed multiple sclerosis patients: the role of identity, sense of coherence, and self-efficacy. J Happiness Stud. 2018;19:277-95.

25. Paziuc LC, Radu MR. The influence of mixed anxiety-depressive disorder on the perceived quality of life in multiple sclerosis patients. Bull Transilvania University of Brasov, Seriels VI: Med Sci. 2018;11:41-50.

26. Prisnie JC, Sajobi TT, Wang M, et al. Effects of depression and anxiety on quality of life in five common neurological disorders. Gen Hosp Psychiatry. 2018 May-Jun;52:58-63. doi: 10.1016/j.genhosppsych.2018.03.009. Epub 2018 Apr 4.

27. Boogar IR, Talepasand S, Jabari M. Psychosocial and Medical Determinants of Health-related Quality of Life in Patients with Relapsing-Remitting Multiple Sclerosis. Noro Psikiyatr Ars. 2018 Mar 19;55(1):29-35. doi: 10.29399/npa.16983

28. Ciampi E, Uribe-San-Martin R, Vasquez M, et al. Relationship between Social Cognition and traditional cognitive impairment in Progressive Multiple Sclerosis and possible implicated neuroanatomical regions. Mult Scler Relat Disord. 2018 Feb;20:122-8. doi: 10.1016/j.msard.2018.01.013. Epub 2018 Jan 31.


For citations:

Zarubina N.V., Spirin N.N. Impact of depression on the quality of life of patients with multiple sclerosis. Neurology, Neuropsychiatry, Psychosomatics. 2023;15(3):41-47. (In Russ.)

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ISSN 2074-2711 (Print)
ISSN 2310-1342 (Online)